The value of combined detection of specific immunoglobulin E, interleukin-6 and regulatory T cells in predicting the risk of postoperative recurrence in patients with eosinophilic chronic rhinosinusitis and nasal polyps
Predicting Postoperative Recurrence in Eosinophilic Sinusitis with Biomarkers
Abstract
Background: To investigate the predictive value of specific immunoglobulin E (sIgE), interleukin-6 (IL-6) and regulatory T cells (Treg) on the risk of postoperative recurrence in patients with eosinophilic chronic sinusitis with nasal polyps (EcRswNP).
Methods: A total of 198 patients with EcRswNP collected to our Hospital from January 2019 to December 2021 were selected as the research subjects. All patients underwent functional endoscopic sinus surgery. The patients were selected to recurrence group (RG, n = 48) and non-recurrence group (NRG, n = 150) on the basis of the recurrence after 1 year of follow-up. The related factors of postoperative recurrence of EcRswNP were analyzed.. The ROC was used to analyze the dangerous of sIgE, IL-6 and Treg in predicting postoperative recurrence of EcRswNP patients.
Results: The proportion of asthma patients, nasal congestion VAS score and peripheral blood Eos% content in the RG were exceed than the NRG, and the Organization Neu % and peripheral blood Neu% levels were less than those in the NRGp (P all < 0.05). The serum sIgE and serum IL-6 in the RG were exceed than the NRG, and the level of peripheral blood Treg was less than the NRG (P < 0.05). Logistic regression analysis showed that high levels of serum sIgE, serum IL-6 and low Treg levels were risk factors for postoperative recurrence (P < 0.05). ROC showed that the AUC of peripheral blood sIgE level, IL-6 and Treg levels alone in predicting the dangerous of postoperative recurrence in patients with EcRswNP were 0.786, 0.707 and 0.636, respectively (all P < 0.05); The AUC of combined prediction of peripheral blood sIgE, IL-6 and Treg levels for postoperative recurrence dangerous in patients with EcRswNP was 0.973, indicating that the efficacy of jointed prediction was exceed than that of single prediction (P < 0.05).
Conclusions: The high levels of sIgE, IL6 and low Treg levels in patients with EcRswNP before operation will increase the risk of postoperative recurrence, which is a risk factor affecting postoperative recurrence, and the three indicators have good predictive value for predicting postoperative recurrence in patients with EcRswNP, and the combination of the three indicators has better value in predicting postoperative recurrence.
References
2. Tomassen P, Vandeplas G, Van Zele T, Cardell LO, Arebro J, Olze H, et al. Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. J Allergy Clin Immun 2016; 137(5): 1449-56.
3. Zhang L, Yu X, Wang J, Lu L, Shi Q. [Effects of different dosages of oral glucocorticoids on short-term recovery and recurrence of eosinophilic chronic rhinosinusitis with nasal polyps]. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021; 35(9): 796-801.
4. Campo P, Eguiluz-Gracia I, Bogas G, Salas M, Plaza SC, Perez N, et al. Local allergic rhinitis: Implications for management. Clin Exp Allergy 2019; 49(1): 6-16.
5. Mirzaei Y, Savari Z, Yazdani-Nafchi F, Salehi-Vanani N, Fallahi E, Pirayesh A, et al. The expression analysis of IL-6, IL-18, IL-21, IL-23, and TGF-beta mRNA in the nasal mucosa of patients with Allergic rhinitis. Afr Health Sci 2022; 22(1): 630-40.
6. Ickrath P, Scherzad A, Kleinsasser N, Ginzkey C, Hagen R, Hackenberg S. Influence of nasal polyp tissue on the differentiation and activation of T lymphocytes in a co-culture system. Biomed Rep 2019; 10(2): 119-26.
7. Chang LH, Chen XH, Li SX, Li X, Huang ZZ, Huang JC, et al. [Expression of CD8(+)Treg cells in chronic rhinosinusitis and its correlation with eosinophilic infiltration]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022; 57(2): 142-52.
8. Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology 2020; 58(Suppl S29): 1-464.
9. Yang QT, Sun YQ, Wu QW, Shi JB. [Interpretation of 2020 European Position Paper on Rhinosinusitis and Nasal Polyps]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020; 55(3): 304-8.
10. Bachert C, Bhattacharyya N, Desrosiers M, Khan AH. Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps. J Asthma Allergy 2021; 14(127-34.
11. Vaitkus J, Vitkauskiene A, Simuntis R, Vaitkus Z, Siupsinskiene N, Vaitkus S. Chronic Rhinosinusitis with Nasal Polyps: Age and Disease Severity Differences in the Levels of Inflammatory Markers. Medicina-Lithuania 2021; 57(3):
12. Bao Q, Zhou Y, Zhang L. Effect of Xinyi Biyan Pill in Adjuvant Treatment of Patients with Chronic Rhinosinusitis and Its Influence on Serum Inflammatory Factors and Immune Function. Evid-Based Compl Alt 2021; 2021: 2228803.
13. Brescia G, Barion U, Zanotti C, Giacomelli L, Martini A, Marioni G. The prognostic role of serum eosinophil and basophil levels in sinonasal polyposis. Int Forum Allergy Rh 2017; 7(3): 261-7.
14. Yang HH, Fang H, You QJ, Han L, Yang ZF, Yu LL, et al. [Predictive study on recurrence of chronic sinusitis with nasal polyps by tissue eosinophils and sinus CT]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018; 53(11): 842-6.
15. Lou H, Meng Y, Piao Y, Wang C, Zhang L, Bachert C. Predictive significance of tissue eosinophilia for nasal polyp recurrence in the Chinese population. Am J Rhinol Allergy 2015; 29(5): 350-6.
16. Ohki Y, Okamoto Y, Iinuma T, Yamamoto H, Toyotome T, Yahiro M, et al. Local fungus-specific Immunoglobulin E production in chronic rhinosinusitis with nasal polyps. Rhinology 2020; 58(2): 136-44.
17. Han J, Wang W, Zhu Z, Wang L, Chen Y, Wang R, et al. Profile of Tissue Immunoglobulin E in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps. Int Arch Allergy Imm 2022; 183(8): 835-42.
18. Lai Y, Hu L, Yang L, Hu X, Song X, Yang J, et al. Interaction Between Serum/Glucocorticoid-Regulated Kinase 1 and Interleukin-6 in Chronic Rhinosinusitis. Allergy Asthma Immun 2021; 13(5): 776-90.
19. Calzada D, Baos S, Cremades-Jimeno L, Cardaba B. Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. J Immunol Res 2018; 2018: 6012053.
20. Li SX, Li X, Chen XH, Wu XF, Huang JC, Lai XP, et al. [The expression of Notch pathway in nasal polyps and its correlation with the decreased Treg percentage and eosinophil infiltration]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021; 56(2): 124-32.
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