Association between Matrix Metalloproteinase-3 Gene Polymorphism and Susceptibility to Chronic Periodontitis: A systematic review and meta-analysis
Gene Polymorphism and Chronic Periodontitis: Meta-Analysis
Abstract
Background: This study aimed to explore the correlation between the MMP-3 1171 5A/6A gene polymorphism and susceptibility to Chronic Periodontitis (CP).
Methods: Following the PRISMA guidelines, a systematic search was conducted across four electronic databases (PubMed, Embase, Web of Science, and Cochrane Library) without any time or language limitations. The selection criteria included case-control studies examining the association between the MMP-3 gene polymorphism and CP. The data were independently extracted and cross-checked by two reviewers. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of the studies. Statistical heterogeneity and publication bias were assessed.
Results: Five studies, published between 2004 and 2019, met the inclusion criteria for the meta-analysis. No significant association was observed between MMP-3 gene polymorphism and CP susceptibility across all subjects in the four gene models. However, subgroup analysis revealed significant differences based on genotyping methods and smoking habits. Using PCR-RFLP genotyping method, the allele and additive models showed a positive correlation with the risk of CP (5A vs 6A, OR=1.12, 95%CI (1.02~1.23); 5A5A vs 6A6A, OR=2.85, 95%CI (1.61~4.86)). In contrast, using Sanger sequencing method, the 5A mutation appeared to reduce CP susceptibility (5A vs 6A, OR=0.77, 95%CI (0.67~0.87); 5A5A vs 6A6A, OR=0.20, 95%CI (0.09~0.42)). Moreover, smoking habits appeared to modulate the risk. Among smokers, the 5A mutation increased susceptibility to CP, while among non-smokers it decreased.
Conclusions: While no significant correlation was found in the overall population, the stratified analysis revealed nuanced relationships contingent on genotyping methods and smoking habits.
References
2. Zhao X, Lin H, Ding T, Wang Y, Liu N, Shen Y. Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment. J Zhejiang Univ-Sc B 2023; 24(5): 373-86.
3. Holla LI, Buckova D, Fassmann A, Halabala T, Vasku A, Vacha J. Promoter polymorphisms in the CD14 receptor gene and their potential association with the severity of chronic periodontitis. J Med Genet 2002; 39(11): 844-8.
4. Liu Y, Xu T, Jiang W, Ma Y, Zhang Q, Chen N, et al. Single-Cell Analyses of the Oral Mucosa Reveal Immune Cell Signatures. J Dent Res 2023; 102(5): 514-24.
5. Majumder P, Ghosh S, Dey SK. Matrix metalloproteinase gene polymorphisms in chronic periodontitis: a case-control study in the Indian population. J Genet 2019; 98: 32.
6. Prideaux M, Staines KA, Jones ER, Riley GP, Pitsillides AA, Farquharson C. MMP and TIMP temporal gene expression during osteocytogenesis. Gene Expr Patterns 2015; 18(1-2): 29-36.
7. Suzuki S, Yamada S. Epigenetics in susceptibility, progression, and diagnosis of periodontitis. Jpn Dent Sci Rev 2022; 58: 183-92.
8. Ding C, Chen X, Zhang PT, Huang JP, Xu Y, Chen N, et al. Matrix Metalloproteinase-3 -1171 5A/6A Polymorphism (rs35068180) is Associated with Risk of Periodontitis. Sci Rep-UK 2015; 5: 11667.
9. Huang X, Ye Q, Zhang Z, Huang X, Zhu Z, Chen Y, et al. Association of matrix metalloproteinase-3 gene 5A/6A polymorphism with the recurrence of ischemic stroke: A prospective observational study. Brain Res 2017; 1674: 55-61.
10. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj-Brit Med J 2021; 372: n71.
11. Zhu H, Ding D, Wang S, Zhu Y. Comparison Between Percutaneous Kyphoplasty and Percutaneous Vertebroplasty in Terms of Efficacy in Osteoporotic Vertebral Compression Fractures: A Meta-analysis. Altern Ther Health M 2022; 28(5): 49-53.
12. Li G, Yue Y, Tian Y, Li JL, Wang M, Liang H, et al. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. Cytokine 2012; 60(2): 552-60.
13. Itagaki M, Kubota T, Tai H, Shimada Y, Morozumi T, Yamazaki K. Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis. J Clin Periodontol 2004; 31(9): 764-9.
14. Astolfi CM, Shinohara AL, Da SR, Santos MC, Line SR, de Souza AP. Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population. J Clin Periodontol 2006; 33(10): 699-703.
15. Loo WT, Wang M, Jin LJ, Cheung MN, Li GR. Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. Arch Oral Biol 2011; 56(10): 1081-90.
16. Letra A, Silva RM, Rylands RJ, Silveira EM, de Souza AP, Wendell SK, et al. MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression. J Clin Periodontol 2012; 39(8): 707-16.
17. Emingil G, Han B, Gurkan A, Berdeli A, Tervahartiala T, Salo T, et al. Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy. J Periodontol 2014; 85(8): 1070-80.
18. Ghilardi G, Biondi ML, Caputo M, Leviti S, DeMonti M, Guagnellini E, et al. A single nucleotide polymorphism in the matrix metalloproteinase-3 promoter enhances breast cancer susceptibility. Clin Cancer Res 2002; 8(12): 3820-3.
19. Li W, Zhu Y, Singh P, Ajmera DH, Song J, Ji P. Association of Common Variants in MMPs with Periodontitis Risk. Dis Markers 2016; 2016: 1545974.
20. Olczak M, Orzechowska MJ, Bednarek AK, Lipinski M. The Transcriptomic Profiles of ESR1 and MMP3 Stratify the Risk of Biochemical Recurrence in Primary Prostate Cancer beyond Clinical Features. Int J Mol Sci 2023; 24(9): 8399.
21. Jickling GC, Liu D, Stamova B, Ander BP, Zhan X, Lu A, et al. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cerebr Blood F Met 2014; 34(2): 185-99.
22. Yang HY, Liu ML, Luo P, Yao XS, Zhou H. Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine. Phytomedicine 2022; 104: 154268.
Copyright (c) 2024 Ankang Hu, Xin Wang, Lisi Ai, Kun Liu, Lingxue Kong
This work is licensed under a Creative Commons Attribution 4.0 International License.
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.