Analysis of Significance of CARD11 and MYO1G Expression in Pulmonary Tuberculosis and Its Predictive Value for Prognosis of Recurrence

  • Tingting Chang Department of Tuberculosis 7 Ward,Shandong Public Health Clinical Center, Shandong University
  • Fengxia Liu Department of Tuberculosis 7 Ward,Shandong Public Health Clinical Center, Shandong University
  • Shengxun Lin Medical Laboratory,Affiliated Nantong Hospital of Shanghai University,The Sixth People’s Hospital of Nantong
  • Li Li Lung function room,Department of respiretory and criticai care medicine,Feicheng peoplle's Hospital
  • Bei Xu Department of Infectious Diseases, Jinan Fourth People's Hospital
DOI: https://doi.org/10.5937/jomb0-54554
Keywords: Pulmonary tuberculosis, CARD11, MYO1G, T cell activation, Analysis of biological information

Abstract


Pulmonary tuberculosis (PTB) is one of the most common infectious diseases worldwide, with extremely high morbidity and mortality. An in-depth understanding of the molecular pathogenesis of PTB is crucial for finding novel diagnostic and therapeutic approaches in the future. In this study, we identified 52 differentially expressed genes (DEGs), which consisted of 422 nodes and 2853 edges, from the GSE34608 dataset in the Gene Expression Omnibus (GEO) database. These DEGs were composed of 422 nodes and 2,853 edges. Functional enrichment analysis revealed that CARD11 and MYO1G are closely related to T-cell activation. Upon further clinical case analysis, we found that the expression of CARD11 and MYO1G in the peripheral blood of patients with PTB were lower than those of healthy individuals, demonstrating excellent diagnostic value for both PTB diagnosis and prognosis of recurrence. Thus, CARD11 and MYO1G are promising indicators for assessing PTB in the future.

Published
2025/01/10
Issue
Vol. 44 No. 2 (2025): Journal of Medical Biochemistry
Section
Original paper

Copyright (c) 2025 Tingting Chang, Fengxia Liu, Shengxun Lin, Li Li, Bei Xu

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