Analysis of the Effect of Ct Angiography Combined with Three Tests, Mmp-9 and Paf, On the Assessment of Postoperative Vascular Stenosis in Acute Coronary Syndrome
Abstract
Background: Acute Coronary Syndrome (ACS) is a very common cardiovascular disease in clinical practice with a very high risk of death. In this study, we observed the effectiveness of CT angiography (CTA), Matrix metalloproteinase-9 (MMP-9) amd Platelet activating factor (PAF) in the assessment of ACS.
Materials and Methods: A total of 124 patients with ACS admitted to our hospital from June 2022 to March 2024 were enrolled as study subjects. All study subjects were examined by Coronary angiography (CAG) and CTA. To compare the detection rate of ACS by CAG and CTA, and the difference in effectiveness in assessing coronary plaque stenosis and plaque calcification. In addition, the levels of MMP-9 and PAF were detected in the patients to analyze their relationship with the degree of stenosis and plaque grade.Subsequently, the effect of the three combined tests, CTA, MMP-9 and PAF, was analyzed for the assessment of postoperative vessel restenosis. Finally, we analyzed the factors associated with poor CTA image quality.
Results: There was no difference in the effectiveness of CTA in detecting ACS, assessing coronary plaque stenosis and plaque calcification compared with CAG (P>0.05). There was a positive correlation between MMP-9, PAF and the degree of coronary stenosis and plaque severity (P<0.05).The diagnostic accuracy of the combination of CTA, MMP-9, and PAF in the diagnosis of stenosis in postoperative ACS was 97.58% (Kappa=0.946). It was determined that 124 patients 21 patients had poor CTA images, and logistic regression analysis showed that shorter breath-hold time and arrhythmia were independent risk factors for poor CTA image quality.
Conclusions: CTA, MMP-9 and PAF are excellent for the diagnosis of stenosis after ACS and shorter breath-hold time and arrhythmia are all independent risk factors for poor CTA image quality.
Copyright (c) 2025 Jia Sun, Yiling Gao, Jing Ma, Minghui Zhu, Kefei Li, Yiyong Hou, Chunqiao Xie, Huang Zhang
This work is licensed under a Creative Commons Attribution 4.0 International License.
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.