Удружење за миР-223-3п и миР-223-5п експресија гена са нивоима ИгЕ, витамина Д и Мг+2 код педијатријских пацијената са астмом
експресија гена миР-223-3п и миР-223-5п са нивоима ИгЕ, витамина Д и Мг+2 код педијатријских пацијената са астмом
Sažetak
Позадина: Астма, глобална незаразна болест, значајно утиче на јавно здравље. Тешки случајеви узрокују високе стопе морбидитета и морталитета, при чему стопа астме код деце у Ираку достиже 20%. Студија је истраживала нивое експресије миР-223-3п и миР-223-5п гена повезаних са педијатријском астмом и утицај ИгЕ, витамина Д и Мг+2 на тежину астме.
Методе: Студија на 140 деце узраста 1-10 година са алергијском астмом спроведена је у Багдаду од новембра 2023. до фебруара 2024. Пацијенти су подељени у три групе: млађи од 1 године, они од 1-5 година и старији од 5 година. Серум ИгЕ, Нивои витамина Д3 и Мг+2 су одређени коришћењем комплета за тестирање имуноглобулина Е.
Резултати: Резултати су указали на значајно повећање нивоа ИгЕ код пацијената (353,812 ± 25,679 нг/мл) у поређењу са контролном групом (25,320 ± 2,581 нг/мл) (п-вредност < 0,01, ниво Вит-Д у серуму је открио значајно смањење у групи пацијената (16,907 ± 0,512 нг/мЛ), док је у контролној групи нивои достигли (32,746 ± 1,629 нг/мЛ), ниво Мг⁺² у серуму смањен у групама пацијената (2,168 ± 0,030 нг/дЛ) у поређењу са контролној групи (2,316 ± 0,028 нг/дЛ) при п-вредности < 0,01, такође, ова студија показује да се повећање експресије гена у генима миР-223-3п и миР-223-5п сматра факторима ризика за алергијску астму. Закључак: Студија је открила да пацијенти са астмом имају висок ниво ИгЕ, низак ниво витамина Д3 и магнезијума и високу експресију гена у генима миР-223-3п и миР-223-5п, факторима ризика за алергијску астму.
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