The Prognostic value of CA15-3, CA125, CEA in breast cancer patients undergoing chemotherapy
Prognostic value of CA15-3, CA125, CEA in breast cancer patients
Keywords:
Exercise intervention under planned behavior planning; Breast tumors; Chemotherapy; Cancer related fatigue; Serum marker levels
Abstract
Objective To explore the prognostic value of cancer antigen 15-3 (CA15-3), Carbohydrate antigen 125 (CA125), Carcino-embryonic antigen (CEA) in breast cancer patients undergoing chemotherapy. Method The data of 100 patients with breast cancer who received chemotherapy in a hospital from May 2022 to May 2024 are selected. Patients are divided into a control group and test group based on different intervention methods and hospital stays. The control group receives routine nursing interventions. The test groupimplements exercise intervention under planned behavior planning, 50 cases in each group. The exercise cognitive score, cancer related fatigue, and serum tumor marker levels of patients are compared before, 2 weeks, and 4 weeks of intervention. Results Before intervention, they had no difference in exercise cognition scores, Cancer-Related Fatigue (CFS) scores, and serum tumor marker levels (P>0.05).After 2 and 4 weeks of intervention, the exercise attitude, exercise values, exercise behavior control, and exercise motivation in the testgroup exceeded the control group,(P<0.05).The scores of behavioral fatigue, sensory fatigue, emotional fatigue, and cognitive fatigue in the test group were below the control group, (P<0.05).The CA15-3, CA125, and CEA in the test group were below the control group, (P<0.05). Conclusion: Exercise intervention under planned behavior planning is conducive to improving the cognition of breast cancer chemotherapy patients on exercise knowledge, alleviating body fatigue, and reducing the serum markers.
References
Álvarez-Bustos, A.,de Pedro, C.G,Romero-Elías, M.,Ramos, J.,Osorio, P.,Cantos, B.,Maximiano, C.,Méndez, M.,Fiuza-Luces, C.,Méndez-Otero, M.,Martín, S.,Cebolla, H., & Ruiz-Casado, A. (2021). Prevalence and correlates of cancer-related fatigue in breast cancer survivors. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(11), 6523-6534.
https://doi.org/10.1007/s00520-021-06218-5.
An, K.Y,Arthuso, F.Z,Kang, D.W,Morielli, A.R,Ntoukas, S.M,Friedenreich, C.M,McKenzie, D.C,Gelmon, K.,Mackey, J.R, & Courneya, K.S (2021). Exercise and health-related fitness predictors of chemotherapy completion in breast cancer patients: pooled analysis of two multicenter trials. Breast cancer research and treatment, 188(2), 399-407. https://doi.org/10.1007/s10549-021-06205-8.
Baghianimoghadam, M.H,Ardakani, M.F,Akhoundi, M.,Mortazavizadeh, M.R,Fallahzadeh, M.H, & Baghianimoghadam, B. (2012). Effect of education on knowledge, attitude and behavioral intention in family relative with colorectal cancer patients based on theory of planned behavior. Asian Pacific journal of cancer prevention : APJCP, 13(12), 5995-8. https://doi.org/10.7314/apjcp.2012.13.12.5995.
Baguley, B.J,Skinner, T.L,Leveritt, M.D, & Wright, O.R (2017). Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol. BMC cancer, 17(1), 1. https://doi.org/10.1186/s12885-016-3022-6.
Belloni, S.,Arrigoni, C., & Caruso, R. (2021). Effects from physical exercise on reduced cancer-related fatigue: a systematic review of systematic reviews and meta-analysis. Acta oncologica (Stockholm, Sweden), 60(12), 1678-1687. https://doi.org/10.1080/0284186X.2021.1962543.
Björkman, K.,Mustonen, H.,Kaprio, T.,Kekki, H.,Pettersson, K.,Haglund, C., & Böckelman, C. (2021). CA125: A superior prognostic biomarker for colorectal cancer compared to CEA, CA19-9 or CA242. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 43(1), 57-70.
https://doi.org/10.3233/TUB-200069.
Bruno, E.,Roveda, E.,Vitale, J.,Montaruli, A.,Berrino, F.,Villarini, A.,Venturelli, E.,Gargano, G.,Galasso, L.,Caumo, A.,Carandente, F., & Pasanisi, P. (2018). Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women. European journal of cancer care, 27(2), 12617.
https://doi.org/10.1111/ecc.12617.
Bell, K.E,Pfeiffer, A.G,Schmidt, S.,Bos, L.,Russell, C.,Barnes, T.,Di Sebastiano, K.M,Avrutin, E.,Gibson, M.,Dubin, J.A, & Mourtzakis, M. (2021). Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study. Scientific reports, 11(1), 22758.
https://doi.org/10.1038/s41598-021-01962-4.
Campos, M.DSB,Feitosa, R.HF,Mizzaci, C.C,Flach, M.DRTV,Siqueira, B.JM, & Mastrocola, L.E (2022). The Benefits of Exercise in Breast Cancer. Arquivos brasileiros de cardiologia, 119(6), 981-990.
https://doi.org/10.36660/abc.20220086
Cardoso, F.,Senkus, E.,Costa, A.,Papadopoulos, E.,Aapro, M.,André, F.,Harbeck, N.,Aguilar Lopez, B.,Barrios, C.H,Bergh, J.,Biganzoli, L.,Boers-Doets, C.B,Cardoso, M.J,Carey, L.A,Cortés, J.,Curigliano, G.,Diéras, V.,El Saghir, N.S,Eniu, A.,Fallowfield, L.,Francis, P.A,Gelmon, K.,Johnston, S.RD,Kaufman, B.,Koppikar, S.,Krop, I.E,Mayer, M.,Nakigudde, G.,Offersen, B.V,Ohno, S.,Pagani, O.,Paluch-Shimon, S.,Penault-Llorca, F.,Prat, A.,Rugo, H.S,Sledge, G.W,Spence, D.,Thomssen, C.,Vorobiof, D.A,Xu, B.,Norton, L., & Winer, E.P (2018). 4th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)†. Annals of oncology : official journal of the European Society for Medical Oncology, 29(8), 1634-1657.
https://doi.org/10.1093/annonc/mdy192.
Cerulla, N.,Arcusa, À.,Navarro, J.B,de la Osa, N.,Garolera, M.,Enero, C.,Chico, G., & Fernández-Morales, L. (2019). Cognitive impairment following chemotherapy for breast cancer: The impact of practice effect on results. Journal of clinical and experimental neuropsychology, 41(3), 290-299.
https://doi.org/10.1080/13803395.2018.1546381.
Chou, H.F,Weng, L.C, & Wang, Y. (2022). Exploring physical activity behavior in middle-aged Taiwanese women based on the theory of planned behavior. Women & health, 62(7), 603-611. https://doi.org/10.1080/03630242.2022.2098893.
Denduluri, N.,Chavez-MacGregor, M.,Telli, M.L,Eisen, A.,Graff, S.L,Hassett, M.J,Holloway, J.N,Hurria, A.,King, T.A,Lyman, G.H,Partridge, A.H,Somerfield, M.R,Trudeau, M.E,Wolff, A.C, & Giordano, S.H (2018). Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Clinical Practice Guideline Focused Update. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 36(23), 2433-2443.
https://doi.org/10.1200/JCO.2018.78.8604.
Gonzalez-Exposito, R.,Semiannikova, M.,Griffiths, B.,Khan, K.,Barber, L.J,Woolston, A.,Spain, G.,von Loga, K.,Challoner, B.,Patel, R.,Ranes, M.,Swain, A.,Thomas, J.,Bryant, A.,Saffery, C.,Fotiadis, N.,Guettler, S.,Mansfield, D.,Melcher, A.,Powles, T.,Rao, S.,Watkins, D.,Chau, I.,Matthews, N.,Wallberg, F.,Starling, N.,Cunningham, D., & Gerlinger, M. (2019). CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. Journal for immunotherapy of cancer, 7(1), 101. https://doi.org/10.1186/s40425-019-0575-3.
Gullett, J.M,Cohen, R.A,Yang, G.S,Menzies, V.S,Fieo, R.A,Kelly, D.L,Starkweather, A.R,Jackson-Cook, C.K, & Lyon, D.E (2019). Relationship of fatigue with cognitive performance in women with early-stage breast cancer over 2 years. Psycho-oncology, 28(5), 997-1003.
https://doi.org/10.1002/pon.5028.
Hameed, I.,Waris, I., & Amin Ul Haq, M. (2019). Predicting eco-conscious consumer behavior using theory of planned behavior in Pakistan. Environmental science and pollution research international, 26(15), 15535-15547.
https://doi.org/10.1007/s11356-019-04967-9.
Han, J.,Zhang, L.,Zhang, Y., & Tang, R. (2021). The Mediating Effect of Positive Illness Cognitions on Experiential Avoidance and Quality of Life in Breast Cancer Patients. Asia-Pacific journal of oncology nursing, 8(4), 427-432. https://doi.org/10.4103/apjon.apjon-20102.
Hanson, L.L,Severson, J.,Kramer, A.F,McAuley, E., & Ehlers, D.K (2020). Differences in cognition and physical activity in younger vs older breast cancer survivors. Psycho-oncology, 29(7), 1228-1231.
https://doi.org/10.1002/pon.5388.
Jones, L.W,Courneya, K.S,Vallance, J.K,Ladha, A.B,Mant, M.J,Belch, A.R, & Reiman, T. (2006). Understanding the determinants of exercise intentions in multiple myeloma cancer survivors: an application of the theory of planned behavior. Cancer nursing, 29(3), 167-75. https://doi.org/10.1097/00002820-200605000-00001.
Karaman, S., & Tan, M. (2021). Effect of Reiki Therapy on Quality of Life and Fatigue Levels of Breast Cancer Patients Receiving Chemotherapy. Cancer nursing, 44(6), 652-658. https://doi.org/10.1097/NCC.0000000000000970.
Karvinen, K.H,Courneya, K.S,Plotnikoff, R.C,Spence, J.C,Venner, P.M, & North, S. (2009). A prospective study of the determinants of exercise in bladder cancer survivors using the Theory of Planned Behavior. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 17(2), 171-9. https://doi.org/10.1007/s00520-008-0471-8.
Kim, J.J,Shin, Y.A, & Suk, M.H (2015). Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy. Journal of exercise nutrition & biochemistry, 19(3), 255-62. https://doi.org/10.5717/jenb.2015.15092812.
Klafke, N.,Mahler, C.,von Hagens, C.,Uhlmann, L.,Bentner, M.,Schneeweiss, A.,Mueller, A.,Szecsenyi, J., & Joos, S. (2019). The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: Results from a randomized controlled trial. Cancer medicine, 8(8), 3666-3676. https://doi.org/10.1002/cam4.2196.
Lee, S., & Vincent, C. (2021). Analysis and Evaluation of the Theory of Planned Behavior. ANS. Advances in nursing science, 44(4), 127-140. https://doi.org/10.1097/ANS.0000000000000369.
Lester, S.P,Kaur, A.S, & Vegunta, S. (2022). Association Between Lifestyle Changes, Mammographic Breast Density, and Breast Cancer. The oncologist, 27(7), 548-554. https://doi.org/10.1093/oncolo/oyac084.
Li, X.,Song, D.,Cao, W.,Zhang, X., & Li, M. (2023). Effects of neoadjuvant chemotherapy combined with breast-conserving surgery on the breast cancer condition and immune and inflammatory indexes of patients with breast cancer. American journal of translational research, 15(4), 2541-2551.
https://doi.org/.PMC10182502.
Liao, Y.C,Ou, Y.C,Wu, C.H,Fu, H.C,Tsai, C.C, & Lin, H. (2021). CA125 normalization within 60 days as an independent prognostic factor for patients with advanced epithelial ovarian cancer. Cancer biomarkers : section A of Disease markers, 32(4), 559-567. https://doi.org/10.3233/CBM-210156.
Matsuoka, J.,Kunitomi, T.,Nishizaki, M.,Iwamoto, T., & Katayama, H. (2018). Advance care planning in metastatic breast cancer. Chinese clinical oncology, 7(3), 33. https://doi.org/10.21037/cco.2018.06.03.
Modi, A.,Purohit, P.,Gadwal, A.,Roy, D.,Fernandes, S.,Vishnoi, J.R,Pareek, P.,Elhence, P.,Misra, S., & Sharma, P. (2021). A Combined Analysis of Serum Growth Differentiation Factor-15 and Cancer Antigen 15-3 Enhances the Diagnostic Efficiency in Breast Cancer. EJIFCC,32(3), 363-376. https://doi.org/.PMC8592631.
Pagola, I.,Morales, J.S,Alejo, L.B,Barcelo, O.,Montil, M.,Oliván, J.,Álvarez-Bustos, A.,Cantos, B.,Maximiano, C.,Hidalgo, F.,Valenzuela, P.L,Fiuza-Luces, C.,Lucia, A., & Ruiz-Casado, A. (2020). Concurrent Exercise Interventions in Breast Cancer Survivors with Cancer-related Fatigue. International journal of sports medicine, 41(11), 790-797. https://doi.org/10.1055/a-1147-1513.
Paramanandam, V.S, & Prema, V.S (2017). Exercise training may improve the tumour microenvironment after breast cancer (PEDro synthesis). British journal of sports medicine, 51(21), 1564-1565.
https://doi.org/10.1136/bjsports-2016-097235.
Pereira, P.R,Oliveira-Junior, M.C,Mackenzie, B.,Chiovatto, J.E,Matos, Y.,Greiffo, F.R,Rigonato-Oliveira, N.C,Brugemman, T.R,Delle, H.,Idzko, M.,Albertini, R.,Ligeiro Oliveira, A.P,Damaceno-Rodrigues, N.R,Caldini, E.G,Fernandez, I.E,Castro-Faria-Neto, H.C,Dolhnikoff, M.,Eickelberg, O., & Vieira, R.P (2016). Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. Medicine and science in sports and exercise, 48(7), 1276-84. https://doi.org/10.1249/MSS.0000000000000907.
Poort, H.,Peters, M.EWJ,van der Graaf, W.TA,Nieuwkerk, P.T,van de Wouw, A.J,Nijhuis-van der Sanden, M.WG,Bleijenberg, G.,Verhagen, C.AHHVM, & Knoop, H. (2020). Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial. Annals of oncology : official journal of the European Society for Medical Oncology, 31(1), 115-122. https://doi.org/10.1016/j.annonc.2019.09.002.
Poort, H.,Peters, M.EWJ,van der Graaf, W.TA,Nieuwkerk, P.T,van de Wouw, A.J,Nijhuis-van der Sanden, M.WG,Bleijenberg, G.,Verhagen, C.AHHVM, & Knoop, H. (2020). Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial. Annals of oncology : official journal of the European Society for Medical Oncology, 31(1), 115-122. https://doi.org/10.1016/j.annonc.2019.09.002.
Ryu, J.M,Kang, D.,Cho, J.,Lee, J.E,Kim, S.W,Nam, S.J,Lee, S.K,Kim, Y.J,Im, Y.H,Ahn, J.S,Park, Y.H,Kim, J.Y,Lee, H.,Kang, M., & Yu, J.H (2023). Prognostic Impact of Elevation of Cancer Antigen 15-3 (CA15-3) in Patients With Early Breast Cancer With Normal Serum CA15-3 Level. Journal of breast cancer, 26(2), 126-135.
https://doi.org/10.4048/jbc.2023.26.e17.
Sabiston, C.M,Wrosch, C.,Castonguay, A.L, & Sylvester, B.D (2018). Changes in physical activity behavior and C-reactive protein in breast cancer patients. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 52(7), 545-551. https://doi.org/10.1093/abm/kax010.
Sacheli, M.A,Neva, J.L,Lakhani, B.,Murray, D.K,Vafai, N.,Shahinfard, E.,English, C.,McCormick, S.,Dinelle, K.,Neilson, N.,McKenzie, J.,Schulzer, M.,McKenzie, D.C,Appel-Cresswell, S.,McKeown, M.J,Boyd, L.A,Sossi, V., & Stoessl, A.J (2019). Exercise increases caudate dopamine release and ventral striatal activation in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 34(12), 1891-1900. https://doi.org/10.1002/mds.27865.
Schwartz, A.L,de Heer, H.D, & Bea, J.W (2017). Initiating Exercise Interventions to Promote Wellness in Cancer Patients and Survivors. Oncology (Williston Park, N.Y.), 31(10), 711-7. https://doi.org/.PMID:29083464.
Singleton, A.,Partridge, S.R,Raeside, R.,Regimbal, M.,Hyun, K.K,Chow, C.K,Sherman, K.,Elder, E., & Redfern, J. (2019). A text message intervention to support women's physical and mental health after breast cancer treatments (EMPOWER-SMS): a randomised controlled trial protocol. BMC cancer, 19(1), 660.
https://doi.org/10.1186/s12885-019-5886-8.
Ting, S.H,Brahmana, R.K,Jerome, C., & Podin, Y. (2022). Survey on determinants of intention to reduce nasopharyngeal cancer risk: an application of the theory of planned behavior. BMC public health, 22(1), 1774.
https://doi.org/10.1186/s12889-022-14073-0.
Tripathi, G.M,Misra, U.K,Kalita, J.,Singh, V.K, & Tripathi, A. (2023). Effect of Exercise on β-Endorphin and Its Receptors in Myasthenia Gravis Patients. Molecular neurobiology, 60(6), 3010-3019.
https://doi.org/10.1007/s12035-023-03247-5.
Tsai, H.Y,Wang, C.J,Mizuno, M.,Muta, R.,Fetzer, S.J, & Lin, M.F (2022). Predictors of cancer-related fatigue in women with breast cancer undergoing 21 days of a cyclic chemotherapy. Worldviews on evidence-based nursing, 19(3), 211-218. https://doi.org/10.1111/wvn.12573.
Tully, R.,Loughney, L.,Bolger, J.,Sorensen, J.,McAnena, O.,Collins, C.G,Carroll, P.A,Arumugasamy, M.,Murphy, T.J,Robb, W.B, & , . (2020). The effect of a pre- and post-operative exercise programme versus standard care on physical fitness of patients with oesophageal and gastric cancer undergoing neoadjuvant treatment prior to surgery (The PERIOP-OG Trial): Study protocol for a randomised controlled trial. Trials, 21(1), 638. https://doi.org/10.1186/s13063-020-04311-4
Veni, T.,Boyas, S.,Beaune, B.,Bourgeois, H.,Rahmani, A.,Landry, S.,Bochereau, A.,Durand, S., & Morel, B. (2019). Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 27(1), 229-238. https://doi.org/10.1007/s00520-018-4320-0.
Wang, Y.S,Ren, S.F,Jiang, W.,Lu, J.Q,Zhang, X.Y,Li, X.P,Cao, R., & Xu, C.J (2021). CA125-Tn ELISA assay improves specificity of pre-operative diagnosis of ovarian cancer among patients with elevated serum CA125 levels. Annals of translational medicine, 9(9), 788. https://doi.org/10.21037/atm-20-8053.
Yi, L.J,Tian, X.,Jin, Y.F,Luo, M.J, & Jiménez-Herrera, M.F (2021). Effects of yoga on health-related quality, physical health and psychological health in women with breast cancer receiving chemotherapy: a systematic review and meta-analysis. Annals of palliative medicine, 10(2), 1961-1975.
https://doi.org/10.21037/apm-20-1484.
Zacharakis, N.,Chinnasamy, H.,Black, M.,Xu, H.,Lu, Y.C,Zheng, Z.,Pasetto, A.,Langhan, M.,Shelton, T.,Prickett, T.,Gartner, J.,Jia, L.,Trebska-McGowan, K.,Somerville, R.P,Robbins, P.F,Rosenberg, S.A,Goff, S.L, & Feldman, S.A (2018). Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. Nature medicine, 24(6), 724-730.
https://doi.org/10.1038/s41591-018-0040-8.
Zhang, H.,Meng, Y.,Jiang, R.,Ge, S., & Song, M. (2023). Effect of Multimodal Exercise on Cancer-Related Fatigue in Patients Undergoing Simultaneous Radiotherapy and Chemotherapy: A Randomized Trial in Patients with Breast Cancer. Alternative therapies in health and medicine, 29(5), 233-237.
https://doi.org/null.PMID:37052972.
https://doi.org/10.1007/s00520-021-06218-5.
An, K.Y,Arthuso, F.Z,Kang, D.W,Morielli, A.R,Ntoukas, S.M,Friedenreich, C.M,McKenzie, D.C,Gelmon, K.,Mackey, J.R, & Courneya, K.S (2021). Exercise and health-related fitness predictors of chemotherapy completion in breast cancer patients: pooled analysis of two multicenter trials. Breast cancer research and treatment, 188(2), 399-407. https://doi.org/10.1007/s10549-021-06205-8.
Baghianimoghadam, M.H,Ardakani, M.F,Akhoundi, M.,Mortazavizadeh, M.R,Fallahzadeh, M.H, & Baghianimoghadam, B. (2012). Effect of education on knowledge, attitude and behavioral intention in family relative with colorectal cancer patients based on theory of planned behavior. Asian Pacific journal of cancer prevention : APJCP, 13(12), 5995-8. https://doi.org/10.7314/apjcp.2012.13.12.5995.
Baguley, B.J,Skinner, T.L,Leveritt, M.D, & Wright, O.R (2017). Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol. BMC cancer, 17(1), 1. https://doi.org/10.1186/s12885-016-3022-6.
Belloni, S.,Arrigoni, C., & Caruso, R. (2021). Effects from physical exercise on reduced cancer-related fatigue: a systematic review of systematic reviews and meta-analysis. Acta oncologica (Stockholm, Sweden), 60(12), 1678-1687. https://doi.org/10.1080/0284186X.2021.1962543.
Björkman, K.,Mustonen, H.,Kaprio, T.,Kekki, H.,Pettersson, K.,Haglund, C., & Böckelman, C. (2021). CA125: A superior prognostic biomarker for colorectal cancer compared to CEA, CA19-9 or CA242. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 43(1), 57-70.
https://doi.org/10.3233/TUB-200069.
Bruno, E.,Roveda, E.,Vitale, J.,Montaruli, A.,Berrino, F.,Villarini, A.,Venturelli, E.,Gargano, G.,Galasso, L.,Caumo, A.,Carandente, F., & Pasanisi, P. (2018). Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women. European journal of cancer care, 27(2), 12617.
https://doi.org/10.1111/ecc.12617.
Bell, K.E,Pfeiffer, A.G,Schmidt, S.,Bos, L.,Russell, C.,Barnes, T.,Di Sebastiano, K.M,Avrutin, E.,Gibson, M.,Dubin, J.A, & Mourtzakis, M. (2021). Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study. Scientific reports, 11(1), 22758.
https://doi.org/10.1038/s41598-021-01962-4.
Campos, M.DSB,Feitosa, R.HF,Mizzaci, C.C,Flach, M.DRTV,Siqueira, B.JM, & Mastrocola, L.E (2022). The Benefits of Exercise in Breast Cancer. Arquivos brasileiros de cardiologia, 119(6), 981-990.
https://doi.org/10.36660/abc.20220086
Cardoso, F.,Senkus, E.,Costa, A.,Papadopoulos, E.,Aapro, M.,André, F.,Harbeck, N.,Aguilar Lopez, B.,Barrios, C.H,Bergh, J.,Biganzoli, L.,Boers-Doets, C.B,Cardoso, M.J,Carey, L.A,Cortés, J.,Curigliano, G.,Diéras, V.,El Saghir, N.S,Eniu, A.,Fallowfield, L.,Francis, P.A,Gelmon, K.,Johnston, S.RD,Kaufman, B.,Koppikar, S.,Krop, I.E,Mayer, M.,Nakigudde, G.,Offersen, B.V,Ohno, S.,Pagani, O.,Paluch-Shimon, S.,Penault-Llorca, F.,Prat, A.,Rugo, H.S,Sledge, G.W,Spence, D.,Thomssen, C.,Vorobiof, D.A,Xu, B.,Norton, L., & Winer, E.P (2018). 4th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)†. Annals of oncology : official journal of the European Society for Medical Oncology, 29(8), 1634-1657.
https://doi.org/10.1093/annonc/mdy192.
Cerulla, N.,Arcusa, À.,Navarro, J.B,de la Osa, N.,Garolera, M.,Enero, C.,Chico, G., & Fernández-Morales, L. (2019). Cognitive impairment following chemotherapy for breast cancer: The impact of practice effect on results. Journal of clinical and experimental neuropsychology, 41(3), 290-299.
https://doi.org/10.1080/13803395.2018.1546381.
Chou, H.F,Weng, L.C, & Wang, Y. (2022). Exploring physical activity behavior in middle-aged Taiwanese women based on the theory of planned behavior. Women & health, 62(7), 603-611. https://doi.org/10.1080/03630242.2022.2098893.
Denduluri, N.,Chavez-MacGregor, M.,Telli, M.L,Eisen, A.,Graff, S.L,Hassett, M.J,Holloway, J.N,Hurria, A.,King, T.A,Lyman, G.H,Partridge, A.H,Somerfield, M.R,Trudeau, M.E,Wolff, A.C, & Giordano, S.H (2018). Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Clinical Practice Guideline Focused Update. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 36(23), 2433-2443.
https://doi.org/10.1200/JCO.2018.78.8604.
Gonzalez-Exposito, R.,Semiannikova, M.,Griffiths, B.,Khan, K.,Barber, L.J,Woolston, A.,Spain, G.,von Loga, K.,Challoner, B.,Patel, R.,Ranes, M.,Swain, A.,Thomas, J.,Bryant, A.,Saffery, C.,Fotiadis, N.,Guettler, S.,Mansfield, D.,Melcher, A.,Powles, T.,Rao, S.,Watkins, D.,Chau, I.,Matthews, N.,Wallberg, F.,Starling, N.,Cunningham, D., & Gerlinger, M. (2019). CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids. Journal for immunotherapy of cancer, 7(1), 101. https://doi.org/10.1186/s40425-019-0575-3.
Gullett, J.M,Cohen, R.A,Yang, G.S,Menzies, V.S,Fieo, R.A,Kelly, D.L,Starkweather, A.R,Jackson-Cook, C.K, & Lyon, D.E (2019). Relationship of fatigue with cognitive performance in women with early-stage breast cancer over 2 years. Psycho-oncology, 28(5), 997-1003.
https://doi.org/10.1002/pon.5028.
Hameed, I.,Waris, I., & Amin Ul Haq, M. (2019). Predicting eco-conscious consumer behavior using theory of planned behavior in Pakistan. Environmental science and pollution research international, 26(15), 15535-15547.
https://doi.org/10.1007/s11356-019-04967-9.
Han, J.,Zhang, L.,Zhang, Y., & Tang, R. (2021). The Mediating Effect of Positive Illness Cognitions on Experiential Avoidance and Quality of Life in Breast Cancer Patients. Asia-Pacific journal of oncology nursing, 8(4), 427-432. https://doi.org/10.4103/apjon.apjon-20102.
Hanson, L.L,Severson, J.,Kramer, A.F,McAuley, E., & Ehlers, D.K (2020). Differences in cognition and physical activity in younger vs older breast cancer survivors. Psycho-oncology, 29(7), 1228-1231.
https://doi.org/10.1002/pon.5388.
Jones, L.W,Courneya, K.S,Vallance, J.K,Ladha, A.B,Mant, M.J,Belch, A.R, & Reiman, T. (2006). Understanding the determinants of exercise intentions in multiple myeloma cancer survivors: an application of the theory of planned behavior. Cancer nursing, 29(3), 167-75. https://doi.org/10.1097/00002820-200605000-00001.
Karaman, S., & Tan, M. (2021). Effect of Reiki Therapy on Quality of Life and Fatigue Levels of Breast Cancer Patients Receiving Chemotherapy. Cancer nursing, 44(6), 652-658. https://doi.org/10.1097/NCC.0000000000000970.
Karvinen, K.H,Courneya, K.S,Plotnikoff, R.C,Spence, J.C,Venner, P.M, & North, S. (2009). A prospective study of the determinants of exercise in bladder cancer survivors using the Theory of Planned Behavior. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 17(2), 171-9. https://doi.org/10.1007/s00520-008-0471-8.
Kim, J.J,Shin, Y.A, & Suk, M.H (2015). Effect of a 12-week walking exercise program on body composition and immune cell count in patients with breast cancer who are undergoing chemotherapy. Journal of exercise nutrition & biochemistry, 19(3), 255-62. https://doi.org/10.5717/jenb.2015.15092812.
Klafke, N.,Mahler, C.,von Hagens, C.,Uhlmann, L.,Bentner, M.,Schneeweiss, A.,Mueller, A.,Szecsenyi, J., & Joos, S. (2019). The effects of an integrated supportive care intervention on quality of life outcomes in outpatients with breast and gynecologic cancer undergoing chemotherapy: Results from a randomized controlled trial. Cancer medicine, 8(8), 3666-3676. https://doi.org/10.1002/cam4.2196.
Lee, S., & Vincent, C. (2021). Analysis and Evaluation of the Theory of Planned Behavior. ANS. Advances in nursing science, 44(4), 127-140. https://doi.org/10.1097/ANS.0000000000000369.
Lester, S.P,Kaur, A.S, & Vegunta, S. (2022). Association Between Lifestyle Changes, Mammographic Breast Density, and Breast Cancer. The oncologist, 27(7), 548-554. https://doi.org/10.1093/oncolo/oyac084.
Li, X.,Song, D.,Cao, W.,Zhang, X., & Li, M. (2023). Effects of neoadjuvant chemotherapy combined with breast-conserving surgery on the breast cancer condition and immune and inflammatory indexes of patients with breast cancer. American journal of translational research, 15(4), 2541-2551.
https://doi.org/.PMC10182502.
Liao, Y.C,Ou, Y.C,Wu, C.H,Fu, H.C,Tsai, C.C, & Lin, H. (2021). CA125 normalization within 60 days as an independent prognostic factor for patients with advanced epithelial ovarian cancer. Cancer biomarkers : section A of Disease markers, 32(4), 559-567. https://doi.org/10.3233/CBM-210156.
Matsuoka, J.,Kunitomi, T.,Nishizaki, M.,Iwamoto, T., & Katayama, H. (2018). Advance care planning in metastatic breast cancer. Chinese clinical oncology, 7(3), 33. https://doi.org/10.21037/cco.2018.06.03.
Modi, A.,Purohit, P.,Gadwal, A.,Roy, D.,Fernandes, S.,Vishnoi, J.R,Pareek, P.,Elhence, P.,Misra, S., & Sharma, P. (2021). A Combined Analysis of Serum Growth Differentiation Factor-15 and Cancer Antigen 15-3 Enhances the Diagnostic Efficiency in Breast Cancer. EJIFCC,32(3), 363-376. https://doi.org/.PMC8592631.
Pagola, I.,Morales, J.S,Alejo, L.B,Barcelo, O.,Montil, M.,Oliván, J.,Álvarez-Bustos, A.,Cantos, B.,Maximiano, C.,Hidalgo, F.,Valenzuela, P.L,Fiuza-Luces, C.,Lucia, A., & Ruiz-Casado, A. (2020). Concurrent Exercise Interventions in Breast Cancer Survivors with Cancer-related Fatigue. International journal of sports medicine, 41(11), 790-797. https://doi.org/10.1055/a-1147-1513.
Paramanandam, V.S, & Prema, V.S (2017). Exercise training may improve the tumour microenvironment after breast cancer (PEDro synthesis). British journal of sports medicine, 51(21), 1564-1565.
https://doi.org/10.1136/bjsports-2016-097235.
Pereira, P.R,Oliveira-Junior, M.C,Mackenzie, B.,Chiovatto, J.E,Matos, Y.,Greiffo, F.R,Rigonato-Oliveira, N.C,Brugemman, T.R,Delle, H.,Idzko, M.,Albertini, R.,Ligeiro Oliveira, A.P,Damaceno-Rodrigues, N.R,Caldini, E.G,Fernandez, I.E,Castro-Faria-Neto, H.C,Dolhnikoff, M.,Eickelberg, O., & Vieira, R.P (2016). Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. Medicine and science in sports and exercise, 48(7), 1276-84. https://doi.org/10.1249/MSS.0000000000000907.
Poort, H.,Peters, M.EWJ,van der Graaf, W.TA,Nieuwkerk, P.T,van de Wouw, A.J,Nijhuis-van der Sanden, M.WG,Bleijenberg, G.,Verhagen, C.AHHVM, & Knoop, H. (2020). Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial. Annals of oncology : official journal of the European Society for Medical Oncology, 31(1), 115-122. https://doi.org/10.1016/j.annonc.2019.09.002.
Poort, H.,Peters, M.EWJ,van der Graaf, W.TA,Nieuwkerk, P.T,van de Wouw, A.J,Nijhuis-van der Sanden, M.WG,Bleijenberg, G.,Verhagen, C.AHHVM, & Knoop, H. (2020). Cognitive behavioral therapy or graded exercise therapy compared with usual care for severe fatigue in patients with advanced cancer during treatment: a randomized controlled trial. Annals of oncology : official journal of the European Society for Medical Oncology, 31(1), 115-122. https://doi.org/10.1016/j.annonc.2019.09.002.
Ryu, J.M,Kang, D.,Cho, J.,Lee, J.E,Kim, S.W,Nam, S.J,Lee, S.K,Kim, Y.J,Im, Y.H,Ahn, J.S,Park, Y.H,Kim, J.Y,Lee, H.,Kang, M., & Yu, J.H (2023). Prognostic Impact of Elevation of Cancer Antigen 15-3 (CA15-3) in Patients With Early Breast Cancer With Normal Serum CA15-3 Level. Journal of breast cancer, 26(2), 126-135.
https://doi.org/10.4048/jbc.2023.26.e17.
Sabiston, C.M,Wrosch, C.,Castonguay, A.L, & Sylvester, B.D (2018). Changes in physical activity behavior and C-reactive protein in breast cancer patients. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 52(7), 545-551. https://doi.org/10.1093/abm/kax010.
Sacheli, M.A,Neva, J.L,Lakhani, B.,Murray, D.K,Vafai, N.,Shahinfard, E.,English, C.,McCormick, S.,Dinelle, K.,Neilson, N.,McKenzie, J.,Schulzer, M.,McKenzie, D.C,Appel-Cresswell, S.,McKeown, M.J,Boyd, L.A,Sossi, V., & Stoessl, A.J (2019). Exercise increases caudate dopamine release and ventral striatal activation in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 34(12), 1891-1900. https://doi.org/10.1002/mds.27865.
Schwartz, A.L,de Heer, H.D, & Bea, J.W (2017). Initiating Exercise Interventions to Promote Wellness in Cancer Patients and Survivors. Oncology (Williston Park, N.Y.), 31(10), 711-7. https://doi.org/.PMID:29083464.
Singleton, A.,Partridge, S.R,Raeside, R.,Regimbal, M.,Hyun, K.K,Chow, C.K,Sherman, K.,Elder, E., & Redfern, J. (2019). A text message intervention to support women's physical and mental health after breast cancer treatments (EMPOWER-SMS): a randomised controlled trial protocol. BMC cancer, 19(1), 660.
https://doi.org/10.1186/s12885-019-5886-8.
Ting, S.H,Brahmana, R.K,Jerome, C., & Podin, Y. (2022). Survey on determinants of intention to reduce nasopharyngeal cancer risk: an application of the theory of planned behavior. BMC public health, 22(1), 1774.
https://doi.org/10.1186/s12889-022-14073-0.
Tripathi, G.M,Misra, U.K,Kalita, J.,Singh, V.K, & Tripathi, A. (2023). Effect of Exercise on β-Endorphin and Its Receptors in Myasthenia Gravis Patients. Molecular neurobiology, 60(6), 3010-3019.
https://doi.org/10.1007/s12035-023-03247-5.
Tsai, H.Y,Wang, C.J,Mizuno, M.,Muta, R.,Fetzer, S.J, & Lin, M.F (2022). Predictors of cancer-related fatigue in women with breast cancer undergoing 21 days of a cyclic chemotherapy. Worldviews on evidence-based nursing, 19(3), 211-218. https://doi.org/10.1111/wvn.12573.
Tully, R.,Loughney, L.,Bolger, J.,Sorensen, J.,McAnena, O.,Collins, C.G,Carroll, P.A,Arumugasamy, M.,Murphy, T.J,Robb, W.B, & , . (2020). The effect of a pre- and post-operative exercise programme versus standard care on physical fitness of patients with oesophageal and gastric cancer undergoing neoadjuvant treatment prior to surgery (The PERIOP-OG Trial): Study protocol for a randomised controlled trial. Trials, 21(1), 638. https://doi.org/10.1186/s13063-020-04311-4
Veni, T.,Boyas, S.,Beaune, B.,Bourgeois, H.,Rahmani, A.,Landry, S.,Bochereau, A.,Durand, S., & Morel, B. (2019). Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 27(1), 229-238. https://doi.org/10.1007/s00520-018-4320-0.
Wang, Y.S,Ren, S.F,Jiang, W.,Lu, J.Q,Zhang, X.Y,Li, X.P,Cao, R., & Xu, C.J (2021). CA125-Tn ELISA assay improves specificity of pre-operative diagnosis of ovarian cancer among patients with elevated serum CA125 levels. Annals of translational medicine, 9(9), 788. https://doi.org/10.21037/atm-20-8053.
Yi, L.J,Tian, X.,Jin, Y.F,Luo, M.J, & Jiménez-Herrera, M.F (2021). Effects of yoga on health-related quality, physical health and psychological health in women with breast cancer receiving chemotherapy: a systematic review and meta-analysis. Annals of palliative medicine, 10(2), 1961-1975.
https://doi.org/10.21037/apm-20-1484.
Zacharakis, N.,Chinnasamy, H.,Black, M.,Xu, H.,Lu, Y.C,Zheng, Z.,Pasetto, A.,Langhan, M.,Shelton, T.,Prickett, T.,Gartner, J.,Jia, L.,Trebska-McGowan, K.,Somerville, R.P,Robbins, P.F,Rosenberg, S.A,Goff, S.L, & Feldman, S.A (2018). Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer. Nature medicine, 24(6), 724-730.
https://doi.org/10.1038/s41591-018-0040-8.
Zhang, H.,Meng, Y.,Jiang, R.,Ge, S., & Song, M. (2023). Effect of Multimodal Exercise on Cancer-Related Fatigue in Patients Undergoing Simultaneous Radiotherapy and Chemotherapy: A Randomized Trial in Patients with Breast Cancer. Alternative therapies in health and medicine, 29(5), 233-237.
https://doi.org/null.PMID:37052972.
Published
2025/04/28
Section
Short Communication
Copyright (c) 2025 Ying Ge
This work is licensed under a Creative Commons Attribution 4.0 International License.
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.