Changes in serum interleukin-6 (IL-6) and C-reactive protein (CRP), PCT after Early Resuscitation in Patients with Severe Acute Pancreatitis:

Jinlong Wang

doi:10.5937/jomb0-55659

Jinlong Wang Department of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China

DOI: https://doi.org/10.5937/jomb0-55659

Keywords: serum interleukin-6 (IL-6) and C-reactive protein (CRP), PCT, Early fluid resuscitation rate; Severe acute pancreatitis; Inflammation; Complications

Abstract

Aim: this work investigated the effects of different early resuscitation fluid replenishment rates (FRRs) on inflammation (serum interleukin-6 (IL-6) and C-reactive protein (CRP), PCT ) and complications in patients with severe acute pancreatitis (SAP).

Methods: Sixty-six patients with SAP were studied. According to the ratio of total fluid replenishment 24 h after admission to that 72 h (FRR), the patients were rolled into a low FRR group (Low group), a moderate FRR group (Moderate group), and a high FRR group (High group), with 22 cases in each. Serum related indexes, APACHE Ⅱ score, HCT, systemic inflammatory response syndrome (SIRS) duration, length of hospital stay (LOS), and complication rate (CR) were determined and compared. Results: The results suggested that ALT, AST, SCr, BUN, TBil, APACHE Ⅱ, scores and HCT in the Moderate group were the lowest (P<0.05), while those in the High group were the highest (P<0.05). After the patients were treated for 72 h, the IL-6, CRP, and PCT in the Low group and the High group were higher than those in the Moderate group, exhibiting differences with P<0.05 and P<0.01, respectively. The SIRS duration and LOS in the Low and High groups were longer and presented differences with P<0.05 and P<0.01 to the Moderate group, respectively. The rates of MODS, mechanical ventilation, pancreatic necrosis infection, and death in the Moderate group were the lowest (P<0.05).

conclusion the moderate FRR could effectively alleviate the inflammatory response of patients with SAP, shorten the treatment time, and reduce the CR

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