Procjena prognostičkog rizika smrti u bolesnika s višestrukom mielomom baziranom na CD184 i CD269: retrospektivna analiza
Sažetak
Background: This study aimed to analyze the expressions of CD184 and CD269 in patients with newly diagnosed multiple myeloma (MM) in China and explored their potential association with prognosis.
Methods: This retrospective study recruited 100 patients with MM and 113 healthy controls who attended Beijing Chaoyang Hospital Shijingshan District between June 2020 and December 2023. The association between CD184 and CD269 expression and patient survival outcomes was assessed using univariable and multivariable Cox proportional hazards regression analyses, alongside Kaplan-Meier survival curves.
Results: Both CD184 and CD269 mRNA were elevated in MM patients compared to controls (P<0.05). By qualitative analysis, it was seen that both CD184+ and CD269 patients had a reduced prognostic overall survival (OS) (P<0.05). Similarly, detection of CD184 and CD269 expression was effective in predicting prognostic mortality in patients.
Conclusion: CD184 and CD269 may serve as valuable prognostic markers in MM patients.
Sva prava zadržana (c) 2025 Hong Chen, Yuan Zhao, Zhiyu Zhang, Yan Xie, Mulan Jin
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