Analysis of Factors Influencing Weight Regain after Bariatric-Metabolic Surgery in Obesity Hypoventilation Syndrome Patients Based on Gastrointestinal Peptide Hormones

  • Jingjing Zhang State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Nephrology, The First Affiliated Hospital of Xinjiang Medical University
  • Shadike Apaer State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia,Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University
  • Shuo Zhang State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia,Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University
  • Guanyou Liang State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia,Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University
  • Tao Li State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia,Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University
  • Xinling Cao State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia,Department of Liver Transplantation & Laparoscopic Surgery, The First Affiliated Hospital of Xinjiang Medical University
DOI: https://doi.org/10.5937/jomb0-57277
Keywords: Gastrointestinal peptide hormones, Weight regain, Laparoscopic sleeve gastrectomy, Obesity hypoventilation syndrome

Abstract


Background: Obesity is becoming increasingly prevalent in modern society, leading to a rise in the incidence of obesity hypoventilation syndrome (OHS). This study analyzes the factors influencing weight regain in OHS patients following laparoscopic sleeve gastrectomy (LSG), based on gastrointestinal peptide hormones.

Methods: A total of 134 OHS patients who underwent LSG at our hospital between January 2023 and January 2024 were enrolled. The alterations in gastrointestinal peptide hormones, including insulin (INS), leptin (Lep), glucagon-like peptide-1 (GLP-1), and ghrelin (GHR), before and after surgery were measured. Subsequently, a 6-month follow-up was conducted. Patients with weight regain were identified, and the predictive value of gastrointestinal peptide hormones for weight regain was analyzed. Logistic regression was then employed to analyze the related factors affecting weight regain.

Results: Following the surgical procedure, a significant increase was observed in the levels of INS, Lep, and GLP, accompanied by a notable decrease in GHR levels among the patients (P < 0.05). During the follow-up period, 32 patients experienced weight regain. The receiver operating characteristic (ROC) curve analysis demonstrated that gastrointestinal peptide hormones exhibited outstanding predictive capabilities for postoperative weight regain. Moreover, through statistical analysis, it was determined that unfavorable dietary habits, lack of regular exercise, trace element deficiencies, and negative emotional states were independent risk factors influencing weight regain following LSG (P < 0.05).

Conclusion: There is a close correlation between gastrointestinal peptide hormones and post-LSG weight alterations in patients with OHS.

Published
2025/05/06
Issue
Vol. 44 No. 8 (2025): Journal of Medical Biochemistry
Section
Original paper

Copyright (c) 2025 Jingjing Zhang, Shadike Apaer, Shuo Zhang, Guanyou Liang, Tao Li, Xinling Cao

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