Association of Serum Inflammatory Factors and Hematologic Parameters With Lower Limb Deep Vein Thrombosis in Neurocritical Patients: A Retrospective Cohort Study

  • Yunqiu Zhu School of Nursing and School of Public Health, Yangzhou University, Yangzhou, Jiangsu, 225009, China
  • Chun Wang Department of Neurointensive Care Unit, Northern Jiangsu People's Hospital
  • Jia Wang Department of Neurointensive Care Unit, Northern Jiangsu People's Hospital
  • Tian Shi Department of Neurointensive Care Unit, Northern Jiangsu People's Hospital
  • Weijie Tang Department of Neurointensive Care Unit, Northern Jiangsu People's Hospital
  • Huaping Zhou Department of Neurointensive Care Unit, Northern Jiangsu People's Hospital
  • Wanfei Guo Department of Neurointensive Care Unit, Northern Jiangsu People's Hospital
  • Hongbin Mei Department of Cardiovascular Medicine, Northern Jiangsu People's Hospital
  • Jinxiang Bo School of Nursing and School of Public Health, Yangzhou University, Yangzhou, Jiangsu, 225009, China
DOI: https://doi.org/10.5937/jomb0-58954
Keywords: neurocritical care, Deep Vein Thrombosis, immunothrombosis, D-dimer

Abstract


Objective: The aim of this study was to investigate the mechanisms of postoperative deep vein thrombosis (DVT) of the lower extremities in neurocritical care patients, focusing on the interaction of inflammatory factors [D-dimer (DD), prothrombin time (PT), blood cell parameters (lymphocytes, platelets, plateletcrit) and coagulation function.

Methods: A retrospective cohort study design was used to include 261 neurocritical care patients who underwent surgery between August 2019 and August 2021. They were categorized into DVT group (n=121) and non-DVT group (n=140) based on postoperative lower limb Doppler ultrasound findings. Preoperative coagulation indices (TT, DD), inflammatory markers [C reactive protein (CRP), procalcitonin (PCT), fibrinogen (FIB)], and blood cell parameters (hemoglobin, neutrophils, lymphocytes, platelet counts, and plateletcrit) were collected from the patients.

Results: DD levels were significantly higher and TT shorter in the DVT group than in the non-DVT group (P<0.05); DD was positively correlated with PT-INR (P<0.001). In addition, lymphocyte and plateletcrit were significantly lower in the DVT group (P<0.05). Multifactorial analysis showed that age (OR=1.027), days of hemostatic medication (OR=1.203), postoperative infections (OR=2.728), elevated DD (OR=1.056), and shortened TT (OR=0.840) were independent risk factors (P<0.05).

Conclusion: The development of DVT in neurocritical patients is the result of a combination of hypercoagulation, inflammatory response, and immunosuppression.

Published
2025/09/24
Issue
Ahead of print
Section
Original paper

Copyright (c) 2025 Yunqiu Zhu, Chun Wang, Jia Wang, Tian Shi, Weijie Tang, Huaping Zhou, Wanfei Guo, Hongbin Mei, Jinxiang Bo

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