Changes in Serum Pain Mediators, Stress Response, Inflammatory Markers, and Coagulation Function in Lumbar Disc Herniation Patients Treated by Musculoskeletal Ultrasound-Guided Needle-knife
Abstract
Objective: To investigate the impacts of musculoskeletal ultrasound (MSK-US)-guided needle-knife on serum pain mediators, stress response, inflammatory markers, and coagulation function in lumbar disc herniation (LDH) patients.
Methods: We recruited 100 LDH patients admitted between February 2024 and January 2025 and assigned them to an MSK-US group (52 cases undergoing MSK-US-guided needle-knife) and a conventional group (48 cases receiving conventional needle-knife). Peripheral venous blood was collected before and within 2 hours postoperatively for IL-6, TNF-α, SP, 5-HT, and hs-CRP measurements by ELISA, Cor, E, and NE determination using an automatic biochemical analyzer, β-EP detection by chemiluminescent immunoassay, and APTT, PT, FIB, and D-D quantification with a coagulation analyzer. Dynamic changes in these biomarkers were analyzed by between- and within-group comparisons.
Results: Both groups demonstrated postoperative reductions in SP and 5-HT and an elevation in β-EP (P<0.05), though no marked inter-group differences were noted (P>0.05). The MSK-US group showed lower postoperative levels of Cor, E, NE, IL-6, hs-CRP, D-D, and FIB than the conventional group (P<0.05), suggesting MSK-US’s ability to reduce inflammation, alleviate stress reaction, and lower hyperfibrinolysis risk.
Conclusion: MSK-US-guided needle-knife is effective in mitigating perioperative stress response and systemic inflammation in LDH patients while reducing the risk of coagulation disorders.
Copyright (c) 2025 Jiaqi Wu, Ming Chen, Wenlong Liu, Jiaming Jiang, Sihan Chen, Tingyu Liu, Xiaoyan Liu
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