engleski
Ključne reči:
engleski
Sažetak
U ovom radu dat je pregled metoda izrade mikrofluidnih uređaja i sistema kao i mogućnosti njihove primene. Mikrofabrikacione metode predstavljaju različite procedure, metode i varijacije. Metodologija izrade mikrofluidinih uređaja direktno utiče na mogućnost njihove primene, kao i primene različitih medijumima. Metode izrade mikrofluidnih uređaja mogu se podeliti na osnovu mehaničkih svojstava materijala. U ovom radu izvršena je podela metoda fabrikacije na osnovu krutosti materijala. Krutost materijala najviše utiče na veličinu i rezoluciju struktura koje se mogu izraditi. Na osnovu krutosti materijala koji se koriste za izradu mikrofluidnih uređaja vrši se klasifikikacija na tvrde, plastične i meke materijale. Tvrdi materijali koji se najčešće primenjuju u procesu fabrikacije su staklo i silikon. Plastični materijali koji se koriste u procesu fabrikacije su Poli(metil metakrilart), Ciklični olefinski kopolimer, itd., dok se primena mekih materijala u procesu fabrikacije bazira na Polimetilsiloksanu. Primena metoda fabrikacije zavisiće i od mogućnost primene u toplim ili hladnim, reaktivnim ili neutralnim sredinama kao i od biokompaktibilnosti samog uređaja. Neke od najrasprostranjenijih metoda izrade mikrofluidnih uređaja predstavljene su fotolitografija i njene varijacije, metode graviranja koje se koriste za staklo i silikon, livenje Polimetilsiloksana, mikroglodanje i 3D štampanje. Kao i papirna mikrofluidika kao primer metode za izradu biokompaktibilinh mikrofluidnih uređaja sa primenom u medicini.
Reference
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[2] Kozomora, V. (2024). Značaj mikromešača u oblasti mikrofluidike. Zbornik radova Fakulteta tehničkih nauka.
[3] Tabeling, P. (2023). Introduction to Microfluidics, Oxford University Press.
[4] Handrea-Dragan, I. M., Botiz, I., Tatar, A. S., & Boca, S. (2022). Patterning at the micro/nano-scale: polymeric scaffolds for medical diagnostic and cell-surface interaction applications. Colloids and Surfaces B: Biointerfaces, 218, 112730.
[5] Wikipedia, (accessed on 30.01.2025.), https://en.wikipedia.org/wiki/Collimated_beam
[6] Gosálvez, M. A., Zubel, I., & Viinikka, E. (2010). Wet etching of silicon. In Handbook of silicon based MEMS materials and technologies (pp. 447-480). Elsevier.
[7] Lucas, N., Demming, S., Jordan, A., Sichler, P., & Büttgenbach, S. (2008). An improved method for double-sided moulding of PDMS. Journal of Micromechanics and Microengineering, 18(7), 075037.
[8] Au, A. K., Huynh, W., Horowitz, L. F., & Folch, A. (2016). 3D‐printed microfluidics. Angewandte Chemie International Edition, 55(12), 3862-3881.
[9] Wikipedia, (accessed on 30.01.2025.), https://en.wikipedia.org/wiki/Coplanarity
[10] Krimpenis, A. A., Fountas, N. A., Ntalianis, I., & Vaxevanidis, N. M. (2014). CNC micromilling properties and optimization using genetic algorithms. The International Journal of Advanced Manufacturing Technology, 70, 157-171.
[11] Wikipedia, (accessed on 30.01.2025.), https://sr.wikipedia.org/wiki/Genetski_algoritam
[12] Waddell, E. A. (2006). Laser ablation as a fabrication technique for microfluidic devices. Microfluidic Techniques: Reviews and Protocols, 27-38.
[13] Nishat, S., Jafry, A. T., Martinez, A. W., & Awan, F. R. (2021). based microfluidics: Simplified fabrication and assay methods. Sensors and Actuators B: Chemical, 336, 129681.
[14] Nguyen, N. T., & Wu, Z. (2004). Micromixers—a review. Journal of micromechanics and microengineering, 15(2), R1.
[15] Barone, S., Neri, P., Paoli, A., Razionale, A. V., & Tamburrino, F. (2019). Development of a DLP 3D printer for orthodontic applications. Procedia manufacturing, 38, 1017-1025.
[16] Wayken Rapid Manucaturing (accessed on 19.02.2025), https://waykenrm.com/blogs/dry-etching-vs-wet-etching/#:~:text=Advantages%20and%20Disadvantages%20of%20Dry%20Etching&text=Doesn't%20use%20a%20large,used%20for%20this%20is%20expensive
[17] Gale, B. K., Jafek, A. R., Lambert, C. J., Goenner, B. L., Moghimifam, H., Nze, U. C., & Kamarapu, S. K. (2018). A review of current methods in microfluidic device fabrication and future commercialization prospects. Inventions, 3(3), 60.
[18] Scott, S. M., & Ali, Z. (2021). Fabrication methods for microfluidic devices: An overview. Micromachines, 12(3), 319.
[19] Rodrigues, R. O., Lima, R., Gomes, H. T., & Silva, A. M. (2015). Polymer microfluidic devices: An overview of fabrication methods. U. Porto Journal of Engineering, 1(1), 67-79.
[20] MIT OpencourseWare, (accessed on 19.02.2025.), https://ocw.mit.edu/courses/6-152j-micro-nano-processing-technology-fall-2005/59b9f31d836355a3380aa156925508bc_lecture17.pdf
[21] Semi cera, (accessed on 19.02.2025.), https://www.semi-cera.com/news/detailed-explanation-of-the-advantages-and-disadvantages-of-dry-etching-and-wet-etching/.
[22] He, Y., Wu, Y., Fu, J. Z., & Wu, W. B. (2015). Fabrication of paper-based microfluidic analysis devices: A review. Rsc Advances, 5(95), 78109-78127.
[23] Zhang, S., Zeng, X., Matthews, D. T. A., Igartua, A., Rodriguez-Vidal, E., Contreras Fortes, J., ... & van der Heide, E. (2016). Selection of micro-fabrication techniques on stainless steel sheet for skin friction. Friction, 4, 89-104.
[24] Choi, K., Kim, S. W., Lee, J. H., Chu, B., & Jeong, D. Y. (2024). Eco‐friendly glass wet etching for MEMS application: A review. Journal of the American Ceramic Society, 107(10), 6497-6515. [25] Pal, P., & Sato, K. (2015). A comprehensive review on convex and concave corners in silicon bulk micromachining based on anisotropic wet chemical etching. Micro and Nano Systems Letters, 3, 1-42.
[26] Li, X., Ballerini, D. R., & Shen, W. (2012). A perspective on paper-based microfluidics: Current status and future trends. Biomicrofluidics, 6(1).
[27] Worty, (accessed on 19.02.2025.), https://www.worthyhardware.com/news/what-is-micro-milling-everything-you-need-to-know/#:~:text=The%20process%20allows%20for%20producing,spindles%20and%20advanced%20control%20systems..
[28] Rawal, S., Sidpara, A. M., & Paul, J. (2022). A review on micro machining of polymer composites. Journal of Manufacturing Processes, 77, 87-113.
[29] Ansari, A., Trehan, R., Watson, C., & Senyo, S. (2021). Increasing silicone mold longevity: A review of surface modification techniques for PDMS-PDMS double casting. Soft materials, 19(4), 388-399.
[30] Shannon, A., O'Connell, A., O'Sullivan, A., Byrne, M., Clifford, S., O'Sullivan, K. J., & O'Sullivan, L. (2020). A radiopaque nanoparticle-based ink using PolyJet 3D printing for medical applications. 3D Printing and Additive Manufacturing, 7(6), 259-268.
[31] Diy connect, (accessed on 19.02.2025.), https://diyconnect.net/popular-applications-of-fdm-3d-printing-technology/
[32] Zhao, L., Liu, Z., Chen, D., Liu, F., Yang, Z., Li, X., ... & Zhou, W. (2021). Laser synthesis and microfabrication of micro/nanostructured materials toward energy conversion and storage. Nano-Micro Letters, 13, 1-48.
[33] Gower, M., (2000). Industrial applications of laser micromachining. Optics express, 7(2), 56-67.
[34] Micronit, (accessed on 19.02.2025.), https://micronit.com/expertise/manufacturing-expertise/dry-etching
[35] Lin, L., & Chung, C. K. (2021). PDMS microfabrication and design for microfluidics and sustainable energy application. Micromachines, 12(11), 1350.
[36] Cano-Vicent, A., Tambuwala, M. M., Hassan, S. S., Barh, D., Aljabali, A. A., Birkett, M., ... & Serrano-Aroca, Á. (2021). Fused deposition modelling: Current status, methodology, applications and future prospects. Additive manufacturing, 47, 102378.
[37] Protec 3D, (accessed on 19.02.2025.), https://protec3d.de/pros-and-cons-of-3d-printing/#:~:text=Selective%20Laser%20Sintering%20(SLS)&text=Disadvantages%3A%20slightly%20rough%20surface%2C%20slow,PA2200%2C%20PA12MD%2C%20etc
[38] Patpatiya, P., Chaudhary, K., Shastri, A., & Sharma, S. (2022). A review on polyjet 3D printing of polymers and multi-material structures. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 236(14), 7899-7926.
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2026/01/15
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