NOVI LEKOVI - ZNAČAJ SLUČAJNOG OTKRIĆA

  • Larisa Đurić Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za farmaciju
  • Maja Milanović Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za farmaciju
  • Nataša Milošević Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za farmaciju
  • Nataša Milić Univerzitet u Novom Sadu, Medicinski fakultet, Katedra za farmaciju
Ključne reči: lekovi, otkriće leka, razvoj leka, repozicioniranje lekova

Sažetak


Ključni elementi serendipiti otkrića su sreća i razmišljanje. Proces otkrića uključuje prepoznavanje potencijala zapažanja na osnovu znanja i iskustva. Slučajna otkrića česta su u polju biomedicinskih nauka. Značajan broj lekova je rezultat serendipiti okolnosti. Antimikrobni agensi, lekovi koji deluju na centralni nervi sistem i antineoplastici su grupe lekova koje su imale najviše benefita od serendipiti otkrića. Osim u tradicionalnom, iracionalnom pristupu dizajnu lekova, slučajna otkrića nisu zaobišla ni neke od savremenih pristupa poput strategija drug repositioning-a i razvoja multi-tagret antitumorskih agenasa. Slučajna otkrića novih lekova mogu se podeliti na laboratorijska i klinička, u zavisnosti od toga u kojoj etapi razvoja leka i pod kojim okolnostima je došlo do spoja nepredviđenih događaja i znanja i sposobnosti istraživača. Otkriće novog leka zahteva izvrsnost u nauci u kojoj prosvećenost, sloboda i otvorenost uma istraživača da deluje, kritički razmišlja, rizikuje i izaziva dogme imaju ključno mesto.

Reference

1. de Rond M. The structure of serendipity. Culture Organ 2014; 20(5): 342-58.
2. Braña MF, Sánchez-Migallón A. Anticancer drug discovery and pharmaceutical chemistry: a history. Clin Transl Oncol 2006; 8(10): 717-28.
3. Colman DR. The three princes of Serendip: notes on a mysterious phenomenon. Mcgill J Med 2006; 9(2): 161-63.
4. Klajn I, Šipka M. Veliki rečnik stranih reči i izraza. 1st ed. Novi Sad: Prometej, 2006.
5. López-Muñoz F, Baumeister AA, Hawkins MF, Alamo C. The role of serendipity in the discovery of the clinical effects of psychotropic drugs: beyond of the myth. Actas Esp Psiquiatr 2012; 40(1): 34-42.
6. Ban TA. The role of serendipity in drug discovery. Dialogues Clin Neurosci 2006; 8(3): 335-44.
7. Milovanović DR, Janković SM, Ružić Zečević D, et al. Lečenje koronavirusne bolesti (COVID-19). Med J 2020; 54(1).
8. Campanario, JM. UsingCitation Classics to study the incidence of serendipity in scientific discovery. Scientometrics 1996; 37: 3-24.
9. Kubinyi H. Chance favors the prepared mind--from serendipity to rational drug design. J Recept Signal Transduct Res 1999; 19(1-4): 15-39.
10. Pina AS, Hussain A, Roque AC. An historical overview of drug discovery. Methods Mol Biol 2009; 572: 3-12.
11. Geromichalos GD, Alifieris CE, Geromichalou EG, Trafalis DT. Overview on the current status of virtual high-throughput screening and combinatorial chemistry approaches in multi-target anticancer drug discovery; Part I. J BUON 2016; 21(4): 764-79.
12. Fu RG, Sun Y, Sheng WB, Liao DF. Designing multi-targeted agents: An emerging anticancer drug discovery paradigm. Eur J Med Chem 2017; 136: 195-211.
13. Hargrave-Thomas E, Yu B, Reynisson J. Serendipity in anticancer drug discovery. World J Clin Oncol 2012; 3(1): 1-6.
14. Sneader W. Drugs Discovered through Serendipity in the Laboratory. In: Sneader W, Drug Discovery: A History. John Wiley & Sons, 2005: 438-45.
15. Zaffiri L, Gardner J, Toledo-Pereyra LH. History of antibiotics. From salvarsan to cephalosporins. J Invest Surg 2012; 25(2): 67-77.
16. Wardrop D, Keeling D. The story of the discovery of heparin and warfarin. Br J Haematol 2008; 141(6): 757-63.
17. Zins GR. The history of the development of minoxidil. Clin Dermatol 1988; 6(4): 132-47.
18. Duffin J. Poisoning the spindle: serendipity and discovery of the anti-tumor properties of the Vinca alkaloids. Can Bull Med Hist 2000; 17(1-2): 155-92.
19. Malaviya AN. Landmark papers on the discovery of methotrexate for the treatment of rheumatoid arthritis and other systemic inflammatory rheumatic diseases: a fascinating story. Int J Rheum Dis 2016; 19(9): 844-51.
20. Cheung-Ong K, Giaever G, Nislow C. DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology. Chem Biol 2013; 20(5): 648-659.
21. Klein DF. The loss of serendipity in psychopharmacology. JAMA 2008; 299(9): 1063-65.
22. Jeste DV, Gillin JC, Wyatt RJ. Serendipity in biological psychiatry--a myth?. Arch Gen Psychiatry 1979; 36(11): 1173-78.
23. Langedijk J, Mantel-Teeuwisse AK, Slijkerman DS, Schutjens MH. Drug repositioning and repurposing: terminology and definitions in literature. Drug Discov Today 2015; 20(8): 1027-34.
24. Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 2004; 3(8): 673-83.
25. Sardana D, Zhu C, Zhang M, Gudivada RC, Yang L, Jegga AG. Drug repositioning for orphan diseases. Brief Bioinform 2011; 12(4): 346-56.
26. Yella JK, Yaddanapudi S, Wang Y, Jegga AG. Changing Trends in Computational Drug Repositioning. Pharmaceuticals (Basel) 2018; 11(2): 57.
27. Desborough MJR, Keeling DM. The aspirin story - from willow to wonder drug. Br J Haematol 2017; 177(5): 674-83.
28. Bai RY, Staedtke V, Rudin CM, Bunz F, Riggins GJ. Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis. Neuro Oncol 2015; 17(4): 545-54.
29. Li H, Xiao H, Lin L, et al. Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface. J Med Chem 2014; 57(3): 632-41.
30. Brodie MJ. Antiepileptic drug therapy the story so far. Seizure 2010; 19(10): 650-55.
31. Crump A, Ōmura S. Ivermectin, 'wonder drug' from Japan: the human use perspective. Proc Jpn Acad Ser B Phys Biol Sci 2011; 87(2): 13-28.
32. Sneader W. Drugs Discovered through Serendipitous Observations Involving Humans In: Sneader W, Drug Discovery: A History. John Wiley & Sons, 2005: 432-37.
33. Ivanović Lj, Stanković R, Štrbac J, Dučić M. Registar lekova 2020. 29th ed. Beograd: BB-Soft, 2020.
Objavljeno
2021/03/25
Rubrika
Pregledni članak