NIVO I ZNAČAJ C-REAKTIVNOG PROTEINA U OSOBA SA METABOLIČKIM SINDROMOM
Ključne reči:
Ključne reči: metabolički sindrom, C-reaktivni protein
Sažetak
Sažetak
Cilj. Dosadašnja istraživanja su pokazala da su nivoi CRP povišeni kod osoba sa metaboličkim sindromom (MS) i da je upala niskog intenziteta karakteristična za MS. Cilj rada je bio da se ispita nivo i značaj serumskog CRP u osoba sa MS.
Metode. Ispitivanjem je obuhvaćeno 149 ambulantnih pacijenata, 67 sa MS (68,9±8,7) i 82 bez MS (68,9±8,6) kao kontrola (p>0,05). CRP je određivan metodom turbidimetrije sa normalnim vrednostima do 5,0 mg/L.
Rezultati. Prosečan nivo CRP-a ispitanika sa MS je 5,33±3,6 mg/L, bez MS 2,46±2,03 mg/L (p<0,001). Nije bilo značajne razlike u koncentracijama CRP-a između muškaraca (6,02±4,88 mg/L) i žena sa MS (4,97±2,87 mg/L) (p>0,05). Nivo CRP veći od 5,0 mg/L imala su 29,8% ispitanika sa MS i 6,1% bez MS (p<0,01).
Zaključak. Značajno veća učestalost povišenih vrednosti i nivoa serumskog CRP u osoba sa MS, u odnosu na one bez MS, ukazuje na značaj inflamacije u patogenezi MS i CRP kao biomarkera i medijatora hronične inflamacije.
Ključne reči: metabolički sindrom, C-reaktivni protein
Reference
L I T E R A T U R A
1. Kumar Sinha S, Goel A, Madaan A, et al. Prevalence of Metabolic Syndrome and Its Clinical and Angiographic Profile in Patients With Naive Acute Coronary Syndrome in North Indian Population. J Clin Med Res 2016; 8:667-673.
2. Mornar Jelavić M. Utjecaj antropometrijskih parametara i metaboličkoga sindroma na težinu i prognozu akutnoga infarkta miokarda sa ST-elevacijom. Doktorska disertacija, Sveučilište u Zagrebu, Stomatološki fakultet, Zagreb 2015.
3. Ford SE, Ajani AU, Mokdad HA. The Metabolic Syndrome and Concentrations of C-Reactive Protein Among U.S. Youth. Diabetes Care 2005; 28:878-881.
4. Ignjatović S. Određivanje visoko osetljivog C-reaktivnog proteina: klinički i analitički kvalitet. Jugoslov Med Biohem 2005;24:85-93.
5. Devaraj S, Singh U, Jialal I. Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol 2009; 20:182-189.
6. Stojanović S. Povezanost nivoa adiponektina u serumu pacijenta u zavisnosti od metaboličkog sindroma i koronarne bolesti. Doktorska disertacija, Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Kragujevac 2014.
7. Gowdiah KP, Mamatha TR, Nirgude D, Hosamani BP. High senzitivity C-reactive protein in metabolic syndrome. International Journal of Advances in Medicine 2016; 3:607-610.
8. Lović M, Đorđević D, Tasić I, Nedeljković I. Impact of metabolic syndrome on clinical severity and long-term prognosis in patients with myocardial infarction with ST-segment elevation. Hellenic Journal of Cardiology 2018; 59:226-231.
9. Ishikawa S, Kayaba K, Gotoh T, Nakamura Y, Kajii E. Metabolic Syndrome and C-Reactive Protein in the General Population. Circulation Journal 2007; 71:26-31.
10. Guven A, Cetinkaya A, Aral M, et al. High-senzitivity C-reactive protein in patienrs with metabolic syndrome. Angiology, 2006; 57:295-302.
11. Najafipour M, Reza Khalaj M, Zareizadeh M, Najafipour N. Relationship between High-senzitivity C-reactive protein. J Res Med Dent Sci 2018; 6:7-11.
12. Horakova D, Pastucha D, Stejskal D, Kollarova H, Azeem K, Janout V. Adipocyte fatty acid binding protein and C-reactive protein levels as indicators of insulin resistence development. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2011; 155:XX. DOI 10.5507/bp.2011.042.
13. Fernandes-Berges D, Consuegra-Sanchez L, Peñafiel J, et al. Metabolic and inflammatory profiles of biomarkers in obesity, metabolic syndrome and diabetes in a Mediterranean population. DARIOS Inflammatory study. Rev Esp Cardiol (Engl Ed) 2014; 67:624-631.
14. Chowta MN, Adhikari PM, Sinha R, Acharya SD, Gopalakrishna HN, Ramapuram JT. Highly sensitive C reactive protein in patients with metabolic syndrome and cardiovascular disease. Ann Trop Med Public Health 2012; 5:98-102
15. Ridker P, Buring J, Cook N, Rifai N. C-reactive protein, the metabolic syndrome and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation 2003; 107:391-397.
16. Cattfesta M, Souza Bissoli N, Bresciani Salaroli L. Metabolic syndrome and C-reactive protein in bank employees. Diabetes, Metabolic Syndrome and Obesity:Targets and Therapy 2016; 9:137-144.
17. Jovelić A, Rađen G, Jovelić S, Marković M. Povezanost C-reaktivnog proteina i karakteristika metaboličkog sindroma kod pilota Vojske Srbije i Crne Gore. Vojnosanit Pregled 2005; 62:811-819.
18. Vasović O. C-reaktivni protein i kardiovaskularni rizik u starih osoba sa diabetes mellitus-om tip 2. Doktorska disertacija, Univerzitet u Beogradu, Medicinski fakultet, Beograd 2013.
19. Jeong H, Baek S, Kim WS, Park JE, Lee J, Kim H, Jeon HC. C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome:results from the Korea National Health and Nutrition Examination Survey. BMJ Open 2019; 9: e029861. doi: 10.1136/bmjopen-2019-029861.
20. Allin K, Nordestgaard B. Elevated C-reactive protein in the diagnosi, prognosis and cause of cancer.Critical Reviews in Clinical Laboratory Sciences 2011; 48:155-170.
21. Woloshin S, Schwartz LM. Distribucion of C-reactive protein values in the United States. N Engl Med 2005; 352:1611-1613.
22. Shin K. The Relationship between Metabolic Syndrome Risk faktors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women. Korean J Clin Lab Sci 2017; 49:121-127.
23. Song Y, Yang KS, Kim J, Lee CD. Association between C-Reactive Protein and Metabolic Syndrome in Korean Adults. Korean J Fam Med 2019; 40:116-123.
24. Lukić LJ. Analiza metaboličkih determinanti nastanka arterijske hipertenzije kod gojaznih pacijenata sa tipom 2 dijabetesa. Doktorska disertacija, Univerzitet u Beogradu, Medicinski fakultet, Beograd,2014.
25. Melika AS. Association between the metabolic syndrome and C-reactive protein in the general population. J Med Sci Res 2018; 1:285-288.
26. Den Engelsen C, Koekkoek PS, Gorter KJ, van den Donk M, Salome PL, Rutten GE. High-sensitivity C-reactive protein to detect metabolic syndrome in a centrally obese population: a cross-sectional analysis. Cardiovascular Diabetology 2012; 11:25.
27. Silva A, Tibana R, Karnikovski M, Funghetto S, Prestes J. Inflammatory status in older with and without metabolic syndrome: is there a correlation with risk factors? Clinical Interventions in Aging 2013; 8:361-367
28. Störk S, Bots LM, Grobbee ED, van der Schouw TY. Endogenous sex hormones in healthy postmenopausal women. Blackwell Publishing Ltd Journal of Internal Medicine 2008; 264:245-253.
29. Park JM, Lee YJ. Serum oestradiol levels are inversely associated with C-reactive protein levels in premenopausal women, but not postmenopausal women. Journal of International Medical Research 2020; 48:1-9.
30. Maggio M, Ceda GP, Lauretani F, Bandinelli S, Corsi AM, Giallauria F, et al. SHBG, sex hormones and inflammatory markers in older women. J Clin Endocrinol Metab 2011; 96:1053-1059.
31. Gaskins A, Wilchesky M, Mumford S, Whitcomb B, Browne R, Wactawski-Wende J, et al. Endogenous Reproductive Hormones and C-reactive Protein Across the Menstrual Cycle. Am J Epidemiol 2012: 175:423-431.
32. Crandall C, Palla S, Reboussin B, Hu P, Barrett-Connor E, Reuben D, Greendale G. Cross-sectional association between markers of inflammation and serum sex steroid levels in the postmenopausal estrogen/progestin interventions trial. J Womens Health (Larchmt) 2006; 15:14-23.
33. Janssen I, Powell L, Craford S, Lasley B, Sutton-Tyrrell K. Menopause and the Metabolic Syndrome: The Study of Women's Health Acrosse the Nation. Arch Intern Med 2008; 168:1568-1575.
34. Ziaei S, Mohseni H. Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women. J Family Reprod Health 2013; 7:63-66.
35. Milić V. Prognostički značaj sistemskog inflamatornog odgovora kod bolesnika sa dijabetes melitusom tip 2 i akutnim infarktom miokarda sa elevacijom ST-segmenta koji su lečeni primarnom perkutanom koronarnom intervencijom. Doktorska disertacija, Univerzitet u Nišu, Medicinski fakultet, Niš 2018.
36. Kanmani S, Kwon M, Shi MK, Kim MK: Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study. Sci Rep 9 2019.
https://doi.org/10.1038/s41598-019-40987-8
37. Mottillo S, Filion KB, Genest J, Pilote L, Poirier P, Reinfret S, et al. The metabolic syndrome ans cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010; 56:1113-1132.
38. Kazlauskinen L, Butnoriene J, Norkus A. Metabolic syndrome related to cardiivascular events in a 10-year prospektive sudy. Diabetology&Metabolic Syndrome 2015; 7(102).
39. Mazlomzadeh S, Karami Zarandi F, Shoghli A, Dinmohammadi H. Metabolic syndrome, its components and mortality: A population-based study. Med J Islam Repub Iran 2019; 33:11.
40. Mozaffarian D, Kamineni A, Prineas RJ, Siscovick DS. Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study. Arch Intern Med 2008; 168:969-978.
1. Kumar Sinha S, Goel A, Madaan A, et al. Prevalence of Metabolic Syndrome and Its Clinical and Angiographic Profile in Patients With Naive Acute Coronary Syndrome in North Indian Population. J Clin Med Res 2016; 8:667-673.
2. Mornar Jelavić M. Utjecaj antropometrijskih parametara i metaboličkoga sindroma na težinu i prognozu akutnoga infarkta miokarda sa ST-elevacijom. Doktorska disertacija, Sveučilište u Zagrebu, Stomatološki fakultet, Zagreb 2015.
3. Ford SE, Ajani AU, Mokdad HA. The Metabolic Syndrome and Concentrations of C-Reactive Protein Among U.S. Youth. Diabetes Care 2005; 28:878-881.
4. Ignjatović S. Određivanje visoko osetljivog C-reaktivnog proteina: klinički i analitički kvalitet. Jugoslov Med Biohem 2005;24:85-93.
5. Devaraj S, Singh U, Jialal I. Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol 2009; 20:182-189.
6. Stojanović S. Povezanost nivoa adiponektina u serumu pacijenta u zavisnosti od metaboličkog sindroma i koronarne bolesti. Doktorska disertacija, Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Kragujevac 2014.
7. Gowdiah KP, Mamatha TR, Nirgude D, Hosamani BP. High senzitivity C-reactive protein in metabolic syndrome. International Journal of Advances in Medicine 2016; 3:607-610.
8. Lović M, Đorđević D, Tasić I, Nedeljković I. Impact of metabolic syndrome on clinical severity and long-term prognosis in patients with myocardial infarction with ST-segment elevation. Hellenic Journal of Cardiology 2018; 59:226-231.
9. Ishikawa S, Kayaba K, Gotoh T, Nakamura Y, Kajii E. Metabolic Syndrome and C-Reactive Protein in the General Population. Circulation Journal 2007; 71:26-31.
10. Guven A, Cetinkaya A, Aral M, et al. High-senzitivity C-reactive protein in patienrs with metabolic syndrome. Angiology, 2006; 57:295-302.
11. Najafipour M, Reza Khalaj M, Zareizadeh M, Najafipour N. Relationship between High-senzitivity C-reactive protein. J Res Med Dent Sci 2018; 6:7-11.
12. Horakova D, Pastucha D, Stejskal D, Kollarova H, Azeem K, Janout V. Adipocyte fatty acid binding protein and C-reactive protein levels as indicators of insulin resistence development. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2011; 155:XX. DOI 10.5507/bp.2011.042.
13. Fernandes-Berges D, Consuegra-Sanchez L, Peñafiel J, et al. Metabolic and inflammatory profiles of biomarkers in obesity, metabolic syndrome and diabetes in a Mediterranean population. DARIOS Inflammatory study. Rev Esp Cardiol (Engl Ed) 2014; 67:624-631.
14. Chowta MN, Adhikari PM, Sinha R, Acharya SD, Gopalakrishna HN, Ramapuram JT. Highly sensitive C reactive protein in patients with metabolic syndrome and cardiovascular disease. Ann Trop Med Public Health 2012; 5:98-102
15. Ridker P, Buring J, Cook N, Rifai N. C-reactive protein, the metabolic syndrome and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation 2003; 107:391-397.
16. Cattfesta M, Souza Bissoli N, Bresciani Salaroli L. Metabolic syndrome and C-reactive protein in bank employees. Diabetes, Metabolic Syndrome and Obesity:Targets and Therapy 2016; 9:137-144.
17. Jovelić A, Rađen G, Jovelić S, Marković M. Povezanost C-reaktivnog proteina i karakteristika metaboličkog sindroma kod pilota Vojske Srbije i Crne Gore. Vojnosanit Pregled 2005; 62:811-819.
18. Vasović O. C-reaktivni protein i kardiovaskularni rizik u starih osoba sa diabetes mellitus-om tip 2. Doktorska disertacija, Univerzitet u Beogradu, Medicinski fakultet, Beograd 2013.
19. Jeong H, Baek S, Kim WS, Park JE, Lee J, Kim H, Jeon HC. C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome:results from the Korea National Health and Nutrition Examination Survey. BMJ Open 2019; 9: e029861. doi: 10.1136/bmjopen-2019-029861.
20. Allin K, Nordestgaard B. Elevated C-reactive protein in the diagnosi, prognosis and cause of cancer.Critical Reviews in Clinical Laboratory Sciences 2011; 48:155-170.
21. Woloshin S, Schwartz LM. Distribucion of C-reactive protein values in the United States. N Engl Med 2005; 352:1611-1613.
22. Shin K. The Relationship between Metabolic Syndrome Risk faktors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women. Korean J Clin Lab Sci 2017; 49:121-127.
23. Song Y, Yang KS, Kim J, Lee CD. Association between C-Reactive Protein and Metabolic Syndrome in Korean Adults. Korean J Fam Med 2019; 40:116-123.
24. Lukić LJ. Analiza metaboličkih determinanti nastanka arterijske hipertenzije kod gojaznih pacijenata sa tipom 2 dijabetesa. Doktorska disertacija, Univerzitet u Beogradu, Medicinski fakultet, Beograd,2014.
25. Melika AS. Association between the metabolic syndrome and C-reactive protein in the general population. J Med Sci Res 2018; 1:285-288.
26. Den Engelsen C, Koekkoek PS, Gorter KJ, van den Donk M, Salome PL, Rutten GE. High-sensitivity C-reactive protein to detect metabolic syndrome in a centrally obese population: a cross-sectional analysis. Cardiovascular Diabetology 2012; 11:25.
27. Silva A, Tibana R, Karnikovski M, Funghetto S, Prestes J. Inflammatory status in older with and without metabolic syndrome: is there a correlation with risk factors? Clinical Interventions in Aging 2013; 8:361-367
28. Störk S, Bots LM, Grobbee ED, van der Schouw TY. Endogenous sex hormones in healthy postmenopausal women. Blackwell Publishing Ltd Journal of Internal Medicine 2008; 264:245-253.
29. Park JM, Lee YJ. Serum oestradiol levels are inversely associated with C-reactive protein levels in premenopausal women, but not postmenopausal women. Journal of International Medical Research 2020; 48:1-9.
30. Maggio M, Ceda GP, Lauretani F, Bandinelli S, Corsi AM, Giallauria F, et al. SHBG, sex hormones and inflammatory markers in older women. J Clin Endocrinol Metab 2011; 96:1053-1059.
31. Gaskins A, Wilchesky M, Mumford S, Whitcomb B, Browne R, Wactawski-Wende J, et al. Endogenous Reproductive Hormones and C-reactive Protein Across the Menstrual Cycle. Am J Epidemiol 2012: 175:423-431.
32. Crandall C, Palla S, Reboussin B, Hu P, Barrett-Connor E, Reuben D, Greendale G. Cross-sectional association between markers of inflammation and serum sex steroid levels in the postmenopausal estrogen/progestin interventions trial. J Womens Health (Larchmt) 2006; 15:14-23.
33. Janssen I, Powell L, Craford S, Lasley B, Sutton-Tyrrell K. Menopause and the Metabolic Syndrome: The Study of Women's Health Acrosse the Nation. Arch Intern Med 2008; 168:1568-1575.
34. Ziaei S, Mohseni H. Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women. J Family Reprod Health 2013; 7:63-66.
35. Milić V. Prognostički značaj sistemskog inflamatornog odgovora kod bolesnika sa dijabetes melitusom tip 2 i akutnim infarktom miokarda sa elevacijom ST-segmenta koji su lečeni primarnom perkutanom koronarnom intervencijom. Doktorska disertacija, Univerzitet u Nišu, Medicinski fakultet, Niš 2018.
36. Kanmani S, Kwon M, Shi MK, Kim MK: Association of C-Reactive Protein with Risk of Developing Type 2 Diabetes Mellitus and Role of Obesity and Hypertension: A Large Population-Based Korean Cohort Study. Sci Rep 9 2019.
https://doi.org/10.1038/s41598-019-40987-8
37. Mottillo S, Filion KB, Genest J, Pilote L, Poirier P, Reinfret S, et al. The metabolic syndrome ans cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 2010; 56:1113-1132.
38. Kazlauskinen L, Butnoriene J, Norkus A. Metabolic syndrome related to cardiivascular events in a 10-year prospektive sudy. Diabetology&Metabolic Syndrome 2015; 7(102).
39. Mazlomzadeh S, Karami Zarandi F, Shoghli A, Dinmohammadi H. Metabolic syndrome, its components and mortality: A population-based study. Med J Islam Repub Iran 2019; 33:11.
40. Mozaffarian D, Kamineni A, Prineas RJ, Siscovick DS. Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study. Arch Intern Med 2008; 168:969-978.
Objavljeno
2022/02/08
Broj časopisa
Rubrika
Originalni naučni članak