CORRELATION BETWEEN LABORATHORY PARAMETERES AND COVID-19 TREATMENT OUTCOME
Abstract
Objective. The aim of this study was to explore the baseline characteristics and correlation of the C-reactive protein, D-dimer, Ferritin and human serum albumins, with the treatment outcome of COVID-19 infection.
Methods. Our study was conducted in the Clinic for infectious diseases at the University Clinical Center Kragujevac during the time frame from November 1st 2020 to February 1st 2021. It was designed as case series and it included patients of age greater than 18 years and positive Polymerase Chain Reaction test or serological (antigen) test on SARS-COV-2 who were treated at our clinic.
Results. A significant correlation was found between human serum albumins (g/L) with the outcome variable p=0.009, while correlation coefficient was 0.466. Also lower level of albumins was significantly correlated with the intrahospital mortality, whereas p=0.007 and correlation coefficient was 0.484.
Conclusion. Our study results suggest that hypoalbuminemia could be possibly used as a significant prognostic factor for intrahospital mortality in COVID-19 patients.
References
2. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA 2020; 323(11): 1061-1069.
3. World Health Organization. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 106, https://www.who.int/emergencies/diseases/novel-coronavirus-2019/ situation-reports (2020).
4. Warusevitane A, Karunatilake D, Sim J, Smith C, Roffe C. Early diag-nosis of pneumonia in severe stroke: clinical features and thediagnostic role of C-reactive protein. PloS one 2016; 11(3): e0150269.
5. Matsumoto H, Kasai T, Sato A, et al. Association between C-reactive protein levels at hospital admission and long-term mortality in patients with acute decompensated heart failure. Heart Vessels 2019; 34(12):1961–8.
6. Lue W, Yu H, Gou J, et al. Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19). Preprints 2020; 1–18.
7. Momeni A, Behradmanesh MS, Kheiri S, Abasi F. Serum ferritin has correlation with HbA1c in type 2 diabetic patients. Adv Biomed Res 2015; 4:74.
8. Chen G, Wu D, Guo W, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020; 130: 2620-2629.
9. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507-513.
10. Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus
disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med 2020; 58: 1021-1028.
11. Bassoli C, Oreni L, Ballone E, et al. Role of serum albumin and proteinuria in patients with SARS-CoV-2 pneumonia. Int J Clin Pract 2020: e13946. doi: 10.1111/ijcp.13946.
12. Yu JS, Pan NN, Chen RD, Zeng LC, Yang HK, Li H. Cardiac Biomarker Levels and Their Prognostic Values in COVID-19 Patients With or Without Concomitant Cardiac Disease. Front Cardiovasc Med 2021; 7: 599096. doi: 10.3389/fcvm.2020.599096.
13. Li T, Wang X, Zhuang X, et al. Baseline characteristics and changes of biomarkers in disease course predict prognosis of patients with COVID-19. Intern Emerg Med 2021; 10:1–8.
14. Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, Zinellu A. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis. Clin Exp Med 2021; 28:1–12.
15. Violi F, Cangemi R, Romiti GF, et al. Is Albumin Predictor of Mortality in COVID-19? Antioxid Redox Signal 2020. doi: 10.1089/ars.2020.8142.