Gliomatoza mozga
Sažetak
Gliomatoza cerebri (GC) predstavlja poseban nozološki entitet među drugim glijalnim tumorima centralnog nervnog sistema (CNS) I klasifikuje se kao difuzni infiltrativni neuroepitelni tumor, koji zahvata najmanje dva moždana režnja. Termin gliomatoza cerebri prvi je predložio Nevin 1938. godine. Od tada je u literaturi opisano samo oko 300 slučajeva
Prikazujemo pacijentkinju staru 59 godina čijom kliničkom slikom su dominirali simptomi I znaci brzo progresivne demencije I parkinsonizma. Nalaz na magnetnoj rezonanci ukazivao je na postojanje gliomatoze, a definitivna dijagnoza postavljenja je MR spektroskopijom: metabolički profil odgovara gliomatozi. Terapijski izbor, obzirom na ekstenzivnost promene, bila je radioterapija. Nakon mesec dana od postavljanja dijagnoze usledio je letalni ishod. U literaturi su do sada opisana samo četiri slična slučaja.
Ključne reči: gliomatoza, demencija, parkinsonizam
Reference
Loius DN, Ohgaki H, Wiestler OD et all. The 2007 WHO classification of tumors of the central nervous system. Acta neuropathol 2007;114:97-109
Armstrong GT, Phillips PC, Rorke Adams LB, Localio AR, Fisher MJ. Gliomatosis ceerbri: 20 years of expirence at the Children at the Children hospital of Philaderphia. Cancer 2006;107:1597-606
Tallibet S, Chodkiewicz C, Laigle-Donadey F et all. A review of 296 cases from the Anocef database and literature. J Neuro-Oncology 2006;76:201-5
Jennings MT, Frenchman M, Shehab T, et al. Gliomatosis cerebri presenting as intractable epilepsy during early childhood. J Child Neurol. 1995;10:37–45
Ross IB, Robitaille Y, Villemure JG, Tampieri D. Diagnosis and management of gliomatosis cerebri: recent trends. Surg Neurol. 1991;36:431–440.
Balakrishnan V, Hornabrook RW, Alexander WS. Gliomatosis cerebri – report of a case. Pathology.1985;17:123–12.
Spagnoli MV, Grossman RI, Packer RJ, et al. Magnetic resonance imaging determination of gliomatosis cerebri. Neuroradiology. 1987;29:15–18.
Kandler RH, Smith CM, Broome JC, Davies-Jones GA. Gliomatosis cerebri: a clinical, radiological and pathological report of four cases. Br J Neurosurg. 1991;5:187–193.
McKeith IG, Dickson DW, Lowe J et al.: Consortium on DLB. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005: 65:1863-72.
Taphoorn MJ, Klein M: Cognitive deficits in adult patients with brain tumours. Lancet Neurol 2004, 3:159-68.
Bhatoe HS: Movement disorders caused by brain tumours. Neurol India 1999, 47:40-2.
Emmanuelle Duron*, Anne Lazareth, Jean-Yves Gaubert, Carole Raso, Olivier Hanonand Anne-Sophie Rigaud. Gliomatosis cerebri presenting as rapidly progressive dementia and parkinsonism in an elderly woman: a case report
Molho ES: Gliomatosis cerebri may present as an atypical parkinsonian syndrome.
Asada T, Takayama Y, Tokuriki y, Fukuyama H: Gliomatosis cerebri presenting as a parkinsonian syndrome. J Neuroimaging 2007; 17:269-71
Slee M, Pretorius P, Ansorge O, Stacey R, Butterworth R: Parkinsonism and dementia due to gliomatosis cerebri mimicking sporadic Creutzfeldt-Jakob disease (CJD).J Neurol Neurosurg Psychiatry 2006; 77:283-4.
Geremia GK, Wollmann R, Foust R. Computed tomography of gliomatosis cerebri. J Comput Assist Tomogr 1988;12:698-701
Felsberg GJ, Silver SA, Brown MT, Tien RD. Gliomatosis cerebri: radiologic-pathologic correlation. AJNR Am J Neuroradiol 1994;15:1745-1751
Raman R, Sobering GS, Franck JA, Dwyer AJ, Alger JR, DiChiro G.Mapping of human brain tumor metabolites with proton MR spectroscopic imaging: clinical relevance. Radiology 1992;185:675-686
Perkins GH, Schomer DF, Fuller GN, Allen PK, Maor MH. Gliomatosis cerebri: improved outcome with radiotherapy. Int J Radiat Oncol Biol Phys. 2003;56(4):1137–1146