Hypervitaminosis B12

Abstract

Increased concentrations of vitamin B12 are the result of
excessive intake of this vitamin, increased release of vitamins
from hepatic depots, or elevated concentrations of
transcobalamin resulting from the increased production or
reduced decomposition of this molecule. The most common
diseases that lead to B12 hypervitaminosis are malignancies
and solid tumours. As a result of elevated concentrations,
acnes emerge or exacerbate the already existing acneiform
changes. Rosacea fulminant, allergic, and other
anaphylactic reactions may also develop. The aim of the
study was to determine the effect of increased concentrations
of vitamin B12 onto human health. In a study conducted by
Deneuvil and associates, the elevated B12 vitamin levels
were observed in 12% of respondents. In the study by Carmel
and associates, 14% of the respondents had high
cobalanemia. The results of other studies show that the
prevalence of high cobalanemia is 13%, while very high
cobalanemia is registered in 7% of cases. In the multicentric
BDOSE study, the incidence of high serum cobalamin was
18%. The increased concentrations of cobalamin are most
commonly caused by a disease, while disorders due to
inadequate intake and overdose are much less common. As a
result of B12 hypervitaminosis, acnes emerge or
exacerbation of the pre-existing acneiform changes may
occur. In addition to acne, other dermatological diseases
(Rosacea fulminant, dermatitis) may develop as a result of
hypervitaminosis, followed by allergic and anaphylactic
reactions.