COMPARATIVE ANALYSIS OF TWO METHODS OF SOCKET PRESERVATION PILOT STUDY
Keywords:
Keywords: A-PRF, xenograft, CBCT, socket preservation, guided bone regeneration.
Abstract
Abstract
Introduction: Volumetric changes of the residual alveolar ridge begin after tooth extraction. They are more pronounced in the vestibule-oral aspect than in the coronary apical aspect. In order to preserve the volume of hard and soft tissues, several types of bone grafts, bone substitutes and biomaterials have been used. PRF as an autologous blood derivative has been used in recent years as an solo graft material or in combination with other graft material.
Objective: Clinical and radiological evaluation of two different methods of socket preservation.
Material and method: Two study groups of 10 subjects each, with socket preservation with solo PRF and PRF+xenograft. Dimensional changes after 4 and 6 months, density of newly formed bone after 4 months with CBCT 3D imaging technique, postoperative morbidity during the first 7 days after intervention were evaluated.
Results: Statistical analysis confirmed lower bone resorption in the PRF+GRAFT test group compared to the PRF group. Better density of newly formed bone in the PRF+GRAFT group and better ratio between the density in the socket and the density in the periapical region. Decreased postoperative morbidity in both groups.
Conclusion: Recommendation for the use of PRF as an adjuvant with other grafts and substitutes, and as a solo graft material.
References
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16. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e51-5. doi: 10.1016/j.tripleo.2005.07.010. PMID: 16504851.
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18. Misch C.E. Density of bone: effect on treatment plans, surgical approach, and healing, and progressive loading. Int J Oral Implantol. 1990;6:23–31
19. Kollati P, Koneru S, Dwarakanath CD, Gottumukkala SNVS. Effectiveness of naturally derived bovine hydroxyapatite (Cerabone™) combined with platelet-rich fibrin matrix in socket preservation: A randomized controlled clinical trial. J Indian Soc Periodontol. 2019 Mar-Apr;23(2):145-151. doi: 10.4103/jisp.jisp_400_18. PMID: 30983786; PMCID: PMC6434722.
20. Yewale M, Bhat S, Kamath A, Tamrakar A, Patil V, Algal AS. Advanced platelet-rich fibrin plus and osseous bone graft for socket preservation and ridge augmentation - A randomized control clinical trial. J Oral Biol Craniofac Res. 2021 Apr-Jun;11(2):225-233. doi: 10.1016/j.jobcr.2021.01.016. Epub 2021 Feb 3. PMID: 33665072; PMCID: PMC7900600.
21. Jambhekar S, Kernen F, Bidra AS. Clinical and histologic outcomes of socket grafting after flapless tooth extraction: a systematic review of randomized controlled clinical trials. J Prosthet Dent. 2015 May 1;113(5):371–382.
22. Castro AB, Van Dessel J, Temmerman A, Jacobs R, Quirynen M. Effect of different platelet-rich fibrin matrices for ridge preservation in multiple tooth extractions: A split-mouth randomized controlled clinical trial. J Clin Periodontol. 2021 Jul;48(7):984-995. doi: 10.1111/jcpe.13463. Epub 2021 Apr 18. PMID: 33847018.
2. Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005 Feb;32(2):212-8. doi: 10.1111/j.1600-051X.2005.00642.x. PMID: 15691354.
3. Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003 Aug;23(4):313-23. PMID: 12956475
4. McAllister BS, Haghighat K. Bone augmentation techniques. J Periodontol. 2007 Mar;78(3):377-96. doi: 10.1902/jop.2007.060048. PMID: 17335361.
5. Hämmerle CH, Araújo MG, Simion M; Osteology Consensus Group 2011. Evidence-based knowledge on the biology and treatment of extraction sockets. Clin Oral Implants Res. 2012 Feb;23 Suppl 5:80-2. doi: 10.1111/j.1600-0501.2011.02370.x. Erratum in: Clin Oral Implants Res. 2012 May;23(5):641. PMID: 22211307.
6. Miron R J, Hedbom N, Saulacic Y et al. Osteogenic Potential of Autogenous Bone Grafts Harvested with Four Different Surgical Techniques. J Dent Res 2011 90: 1428
7. Choukroun J, Adda F, Schoeffler C, Vervelle A. The PRF: an opportunity in implantology. Implantodontie. 2001;42:55–62.
8. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62:489–496
9. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e45-50. doi: 10.1016/j.tripleo.2005.07.009. Epub 2006 Jan 10. PMID: 16504850.
10. Al-Hamed FS, Mahri M, Al-Waeli H, Torres J, Badran Z and Tamimi F (2019) Regenerative Effect of Platelet Concentrates in Oral and Craniofacial Regeneration. Front. Cardiovasc. Med. 6:126. doi: 10.3389/fcvm.2019.00126
11. Dolati S, Yousefi M, Pishgahi A, Nourbakhsh S, Pourabbas B, Shakouri SK. Prospects for the application of growth factors in wound healing. Growth Factors. 2020 Jan;38(1):25-34. doi: 10.1080/08977194.2020.1820499. Epub 2020 Nov 5. PMID: 33148072.
12. Baca-Gonzalez L, Serrano Zamora R, Rancan L, González Fernández-Tresguerres F, Fernández-Tresguerres I, López-Pintor RM, López-Quiles J, Leco I, Torres J. Plasma rich in growth factors (PRGF) and leukocyte-platelet rich fibrin (L-PRF): comparative release of growth factors and biological effect on osteoblasts. Int J Implant Dent. 2022 Oct 3;8(1):39. doi: 10.1186/s40729-022-00440-4. PMID: 36184700; PMCID: PMC9527267.
13. Baca-Gonzalez L, Serrano Zamora R, Rancan L, González Fernández-Tresguerres F, Fernández-Tresguerres I, López-Pintor RM, López-Quiles J, Leco I, Torres J. Plasma rich in growth factors (PRGF) and leukocyte-platelet rich fibrin (L-PRF): comparative release of growth factors and biological effect on osteoblasts. Int J Implant Dent. 2022 Oct 3;8(1):39. doi: 10.1186/s40729-022-00440-4. PMID: 36184700; PMCID: PMC9527267.
14. Pitzurra L, Jansen IDC, de Vries TJ, Hoogenkamp MA, Loos BG. Effects of L-PRF and A-PRF+ on periodontal fibroblasts in in vitro wound healing experiments. J Periodontal Res. 2020 Apr;55(2):287-295. doi: 10.1111/jre.12714. Epub 2019 Nov 28. PMID: 31782171; PMCID: PMC7154757.
15. Nguyen M, Nguyen TT, Tran HLB, Tran DN, Ngo LTQ, Huynh NC. Effects of advanced platelet-rich fibrin combined with xenogenic bone on human periodontal ligament stem cells. Clin Exp Dent Res. 2022 Aug;8(4):875-882. doi: 10.1002/cre2.563. Epub 2022 Mar 26. PMID: 35338771; PMCID: PMC9382045.
16. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e51-5. doi: 10.1016/j.tripleo.2005.07.010. PMID: 16504851.
17. Miron RJ, Zhang Y. Autologous liquid platelet rich fibrin: A novel drug delivery system. Acta Biomater. 2018 Jul 15;75:35-51. doi: 10.1016/j.actbio.2018.05.021. Epub 2018 May 15. PMID: 29772345.
18. Misch C.E. Density of bone: effect on treatment plans, surgical approach, and healing, and progressive loading. Int J Oral Implantol. 1990;6:23–31
19. Kollati P, Koneru S, Dwarakanath CD, Gottumukkala SNVS. Effectiveness of naturally derived bovine hydroxyapatite (Cerabone™) combined with platelet-rich fibrin matrix in socket preservation: A randomized controlled clinical trial. J Indian Soc Periodontol. 2019 Mar-Apr;23(2):145-151. doi: 10.4103/jisp.jisp_400_18. PMID: 30983786; PMCID: PMC6434722.
20. Yewale M, Bhat S, Kamath A, Tamrakar A, Patil V, Algal AS. Advanced platelet-rich fibrin plus and osseous bone graft for socket preservation and ridge augmentation - A randomized control clinical trial. J Oral Biol Craniofac Res. 2021 Apr-Jun;11(2):225-233. doi: 10.1016/j.jobcr.2021.01.016. Epub 2021 Feb 3. PMID: 33665072; PMCID: PMC7900600.
21. Jambhekar S, Kernen F, Bidra AS. Clinical and histologic outcomes of socket grafting after flapless tooth extraction: a systematic review of randomized controlled clinical trials. J Prosthet Dent. 2015 May 1;113(5):371–382.
22. Castro AB, Van Dessel J, Temmerman A, Jacobs R, Quirynen M. Effect of different platelet-rich fibrin matrices for ridge preservation in multiple tooth extractions: A split-mouth randomized controlled clinical trial. J Clin Periodontol. 2021 Jul;48(7):984-995. doi: 10.1111/jcpe.13463. Epub 2021 Apr 18. PMID: 33847018.
Published
2024/03/24
Section
Original Scientific Paper