Low dose CT in detection of lung cancer –preliminary raport
Sažetak
Lung cancer is the most common cause of cancer death worldwide. Every year in the world more people dies from lung cancer. Approximately 300 people in the Montenegro are diagnosed with lung cancer each year . Success in the treatment can be achieved by implementing screening programs.
From November 2013 through November 2014, a total of 120 asymptomatic men and women older than 50 with at least a 20 pack-year history of smoking were randomly assigned to undergo LDCT lung cancer screening. In 26% (32 individuals), one or more pulmonary nodules were detected. In our study low dose CT found asymptomatic lung cancer in 3.3% of scanned patients at one year into our study. We ordered biopsy for four nodules with malignant characteristic The rest of the nodules showed no enlargement during a follow-up period of 24 months and were presumed non-malignant.
In conclusion, in the current study, low-dose spiral CT was feasible for depicting small lung cancers by using a simple algorithm based on the size and attenuation of detected nodules to guide invasive procedures.
Reference
Malvezzi M., Bertuccio P., Rosso T., Rota M., Levi F., La Vecchia C., Negri E. European cancer mortality predictions for the year 2015: does lung cancer have the highest death rate in EU women? Annals of Oncology 2014; 26(4): 779-786.
National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365: 395-409.
Diederich S1, Wormanns D, Semik M, Thomas M, Lenzen H, Roos N, Heindel W.Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers.Radiology. 2002 Mar;222(3):773-81.
National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR, Berg CD, Clingan KL, Duan F, Fagerstrom RM, Gareen IF, Gierada DS, et al. Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med. 2013 May 23; 368(21):1980-91.
Lopes PA, Picozzi G, Falaschi F, Carrozzi L, Falchini M, Carozzi FM, Pistelli F, Comin C, Deliperi A, Grazzini M, Innocenti F, Maddau C, Vella A, Vaggelli L, Paci E, Mascalchi M:Four-year results of low-dose CT screening and nodule management in the ITALUNG trial. J Thorac Oncol 2013, 8:866-875.
Swensen SJ, Jett JR, Hartman TE, et al. Lung cancer screening with CT: Mayo Clinic experience.Radiology. 2003;226:756–761. (PubMed)
National Lung Screening Trial Research T, Church TR, Black WC, Aberle DR, Berg CD, et al. (2013)Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med 368: 1980–1991 doi: 10.1056/NEJMoa120912023697514 (PMC free article) (PubMed)
J. Vansteenkiste, C. Dooms, C. Mascaux, and K. Nackaerts. Screening and early—detection of lung cancer. Ann. Onc. 2012 23: x320-x327.
Stephen G Spiro Screening for lung cancer: we still need to know more. Thorax 2012;67:283-285 doi:10.1136/thoraxjnl-2011-201541
Patz EF, Jr, Pinsky P, Gatsonis C, et al. Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer.JAMA Intern Med. 2014;174(2):269-274. doi:10.1001/jamainternmed.2013.12738.
Anthony B. Miller Screening for Lung Cancer With Low-Dose Computed Tomography. The Oncologist August 2013 vol. 18 no. 8 897-899.
Saghir Z, Dirksen A, Ashraf H et al. CT screening for lung cancer brings forward early disease: The randomised Danish Lung Cancer Screening Trial: Status after five annual screening rounds with low-dose CT. Thorax2012;67:296-301.
Macmahon H, Austin JH, Gamsu G et-al. Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. Radiology. 2005;237 (2): 395-400. doi:10.1148/radiol.2372041887 -Pubmed citation
Stojanović, S., Petrović, K., Anđelić, D., Njagulj, V., Krsmanović, A.& Boban, N. 2009, Mogućnosti niskodoznog CT protokola u skriningu karcinoma pluća, Acta chirurgica iugoslavica, vol. 56, no. 4, pp. 57-62.
M Mascalchi, L N Mazzoni, M Falchini, G Belli, G Picozzi, V Merlini, A Vella, S Diciotti, F Falaschi, A Lopes Pegna, and E Paci, Dose exposure in the ITALUNG trial of lung cancer screening with low-dose CT, The British Journal of Radiology 2012 85:1016, 1134-1139
- Autori zadržavaju autorska prava i pružaju časopisu pravo prvog objavljivanja rada i licenciraju ga Creative Commons Attribution licencom koja omogućava drugima da dele rad, uz uslov navođenja autorstva i izvornog objavljivanja u ovom časopisu.
- Autori mogu izraditi zasebne, ugovorne aranžmane za neekskluzivnu distribuciju rada objavljenog u časopisu (npr. postavljanje u institucionalni repozitorijum ili objavljivanje u knjizi), uz navođenje da je rad izvorno objavljen u ovom časopisu.
- Autorima je dozvoljeno i podstiču se da postave objavljeni rad onlajn (npr. u institucionalni repozitorijum ili na svoju internet stranicu) pre ili tokom postupka prijave rukopisa, s obzirom da takav postupak može voditi produktivnoj razmeni ideja i ranijoj i većoj citiranosti objavljenog rada (Vidi Efekte otvorenog pristupa).