Frequency of causative agents of urinary tract infections in patients from the territory of the City of Prokuplje

  • Svetlana Bogdanović Toplička akademija strukovnih studija, Prokuplje
  • Ivana Zlatković Toplička akademija strukovnih studija, Prokuplje
  • Zvonko Zlatanovic Toplička akademija strukovnih studija, Prokuplje
  • Dobrila Randjelovic Toplička akademija strukovnih studija, Prokuplje
  • Nebojsa Vacic UKC Niš, Klinika za transfuziologiju
Keywords: urinary infections, urine, microorganisms

Abstract


Every year, around 150 million people worldwide are diagnosed with some type of urinary tract infection. Urinary tract infections are the second most common, after respiratory infections. The aim of this paper is the microbiological analysis of the urine of primary health care patients on the territory of the municipality of Prokuplje. The six-month urinalysis included a total of 706 samples. Of the tested samples, 388 (54.96%) were positive for pathogenic microorganisms. The most common pathogen is E. coli with a share of 67.52% in relation to the number of positively tested samples. Then follow Proteus spp. with 10.57%, Enterococcus spp. with 9.54%, Enterobacter spp. with 5.67%, Klebsiella spp. with 2.58%, Psedomonas aeruginosa with 1.55%, S. aureus with 1.03% and C. albicans and Gardnerella vaginalis with 0.77% each in relation to the number of positively tested samples. According to the gender distribution of Gram-negative bacteria, the most common among women is Proteus spp. (82.93%), while in men the most common Klebsiella spp. (80%). Of the Gram-positive bacteria, S. aureus and Gardnerella vaginalis are 100% present only in the female population, as is C. albicans. When choosing antibiotic therapy for patients with urinary infections, it is very important to harmonize the therapy with the age and gender of the patient.

References

Alós JI. 2005. Epidemiology and etiology of urinary tract infections in the community. Antimicrobial susceptibility of the main pathogens and clinical significance of resistance. Enferm Infecc Microbiol Clin; 23(Suppl 4): 3−8. https://doi.org/10.1157/13091442


Darouiche, R. O., W. H. Donovan, M. Del Terzo, J. I. Thornby, D. C. Rudy, and R. A. Hull. 2001. Pilot trial of bacterial interference for preventing urinary tract infection. Urology 58:339-344. DOI:https://doi.org/10.1016/S0090-4295(01)01271-7


Đorđević Z, Folić M, Janković S. 2016. Vanbolničke infekcije urinarnog trakta: uzročnici i njihova rezistencija na antimikrobne lekove. Vojnosanit Pregl (Beograd); 73(12):1109–1115. doi: 10.2298/VSP150122218D


Foxman, B. 2002. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am. J. Med. 113(Suppl. 1A):5S-13S DOI:https://doi.org/10.1016/S0002-9343(02)01054-9


Gordon I, Barkovics M, Pindoria S, Cole TJ, Woolf AS. 2003. Primary vesicoureteric reflux as a predictor of renal damage in children hospitalized with urinary tract infection: a systematic review and meta-analysis. J Am Soc Nephrol;14:739–44. DOI: https://doi.org/10.1097/01.ASN.0000053416.93518.63


Hooton TM. 2012. Clinical practice. Uncomplicated urinary tract infection. N Engl J Med; 366(11): 1028−37. DOI: 10.1056/NEJMcp1104429


Laupland KB, Ross T, Pitout JD, Church DL, Gregson DB. 2007. Community-onset urinary tract infections: A population-based assessment. Infection.; 35(3): 150−3. doi: 10.1007/s15010-007-6180-2.


Lazarević J.,Nikolić B., Malešević Z., Ninković V. 2022. Antibiotska rezistencija uzročnika infekcija urinarnog trakta kod pacijenata instituta za javno zdravlje Kragujevac.Zdravstvena zaštita 51(2): 56-70. DOI: https://www.doi.org/10.5937/zdravzast51-36978


Mačužić B, Vujić A, Janković S.2013. Antibiotic resistance is the cause of urinary tract infections in children. Med J (Krag); 47(4): 185−91.


Matić S, Ninković V, Arsović A, Obrenović N, Baskić D. 2012. Osetljivost urinarnih patogena na antimikrobnu terapiju kod pacijenata u primarnoj zdravstvenoj zaštiti. Med Čas (Kragujevac); 46(3):126-131. doi: 10.5937/mckg46-1899


Milinković B., Bokonjić D., Joksimović B.N., Kulić V., ŠupićV. 2018. Karakteristike urinarnih infekcija u djece do 7 godina. Biomedicinska istraživanja;9(1):92–102. DOI: 10.7251/BII1801092M


RonaldA. 2002. The etiology of urinary tract infection: traditional and emerging pathogens. am J Med; 113(Suppl 1a): 14S–19S. doi: 10.1016/s0002-9343(02)01055-0.


Trautner, B. W., R. O. Darouiche, R. A. Hull, S. Hull, and J. I. Thornby. 2002. Pre-inoculation of urinary catheters with Escherichia coli 83972 inhibits catheter colonization by Enterococcus faecalis. J. Urol. 167:375-379.  PMCID: PMC2963589


Uzunovic-Kamberovic S. 2006. Antibiotic resistance of coliform organisms from community-acquired urinary tract infections in Zenica-Doboj Canton, Bosnia and Herzegovina. J Antimicrob Chemother; 58(2): 344−8. DOI: 10.1093/jac/dkl243

Published
2023/04/02
Section
Professional Paper