ULOGA FARMACEUTA U PREVENCIJI I OTKRIVANJU INTERAKCIJA OTC PREPARATA: TEHNIKA NOMINALNE GRUPE

Miloš N Milosavljević; Srdjan M Stefanovic; Milica N Milosavljevic; Aleksandar G Kocovic; Slobodan M Jankovic

doi:10.5937/racter10-14500

Miloš N Milosavljević "Univerzitet u Kragujevcu, Fakultet Medicinskih Nauka, Odsek za farmaciju
Srdjan M Stefanovic "Univerzitet u Kragujevcu, Fakultet Medicinskih Nauka, Odsek za klinicku farmaciju
Milica N Milosavljevic Univerzitet u Pristini, Medicinski fakultet
Aleksandar G Kocovic Univerzitet u Kragujevcu, Fakultet Medicinskih Nauka, Odsek za farmaceutsku analizu
Slobodan M Jankovic Univerzitet u Kragujevcu, Fakultet Medicinskih Nauka, Odsek za farmakologiju i toksikologiju

DOI: https://doi.org/10.5937/racter10-14500

Ključne reči: inappropriate prescribing||, ||farmaceut, risk factors||, ||otc preparati, elderly||, ||interakcije, grounded theory||, ||interaction checker-i,

Sažetak

Uvod: Broj novih OTC preparata koji se pojavljuju na tržištu nalazi se u stalnom porastu, što farmaceutima otežava postupak izdavanja, naročito u pogledu prevencije potencijalnih interakcija u koje ti preparati mogu da stupe sa drugim lekovima, s obzirom da o interakcijama novih OTC preparata nema dovoljno informacija. Cilj: Ispitivanje problema sa kojima se farmaceuti sreću prilikom izdavanja OTC preparata i predlaganje konkretnih ideja i načina za unapređenje sistema otkrivanja interakcija OTC preparata.Ispitanici i metod: Istraživanje je sprovedeno u skladu sa metodološkim principima tehnike nominalne grupe. U okviru istraživanja sprovedena su dva sastanka nominalne grupe sa farmaceutima zaposlenim u javnim apotekama. U toku sastanaka moderator istraživanja je ispitanicima postavljao određena pitanja, na koje su ispitanici odgovarali. Kako bi se ispitala saglasnost ispitanika oko svake pojedinačne tvrdnje, ispitanici su na kraju oba sastanka postavljene tvrdnje anonimno ocenjivali po principima Likertove skale. Sastanci su snimani i audio zapisi sastanaka su kasnije korišćeni za kvalitativnu analizu podataka.Rezultati: U istraživanju je učestvovalo 9 farmaceuta - 7 farmaceuta ženskog pola i 2 muškog pola, prosečne starosti 25.0 ± 1.0 godina. Učesnici nominalne grupe su na sastancima izneli 30 tvrdnji na 7 postavljenih istraživačkih pitanja, pri čemu je nakon drugog sastanka saglasnost postignuta za 29 tvrdnji. Kvalitativna analiza dobijenih podataka ukazala je na postojanje 3 kategorije tvrdnji: (1) znanje farmaceuta o interakcijama OTC preparata, (2) problemi sa kojima se oni susreću prilikom izdavanja OTC preparata i (3) mogućnosti unapređenja sistema za prevenciju i otkrivanje interakcija OTC preparata.Zaključak: Za adekvatnu prevenciju interakcija OTC preparata sa drugim lekovima neophodno je izraditi vodiče sa smernicama koje se odnose na pravilan postupak izdavanja OTC preparata i redovno koristiti «proveravač interakcija» (engl. interaction checker).

Biografija autora

Miloš N Milosavljević, "Univerzitet u Kragujevcu, Fakultet Medicinskih Nauka, Odsek za farmaciju

Magistar farmacije

Reference

Gavronski M, Volmer D. Safety concerns in simulta-neous use of prescription and 'over-the-counter' medi-cines- results of patient survey in Estonia. Springerplus 2014;3:143.

Schmiedl S, Rottenkolber M, Hasford J, et al. Self-medication with over-the-counter and prescribed drugs causing adverse-drug-reaction-related hospital admis-sions: results of a prospective, long-term multi-centre study. Drug Saf 2014;37(4):225-35.

Eickhoff C, Hämmerlein A, Griese N, Schulz M. Nature and frequency of drug-related problems in self-medication (over-the-counter drugs) in daily community pharmacy practice in Germany. Pharmacoepidemiol Drug Saf 2012;21(3):254-60.

Calamusa A, Di Marzio A, Cristofani R, et al. Factors that influence Italian consumers' understanding of over-the-counter medicines and risk perception. Patient Educ Couns 2012;87(3):395-401.

Nomura K, Kitagawa Y, Yuda Y, Takano-Ohmuro H. Medicine reclassification processes and regulations for proper use of over-the-counter self-care medicines in Japan. Risk Manag Healthc Policy 2016;9:173-83.

Albert SM, Bix L, Bridgeman MM, et al. Promoting safe and effective use of OTC medications: CHPA-GSA National Summit. Gerontologist 2014;54(6):909-18.

Javna agencija Republike Slovenije za zdravila in medi-cinske pripomočke. Podatkio zdravilih in medicinskih pripomočkih. Centralna baza zdravil. Посећено у септембру 2017. године на: http://www.cbz.si/cbz/bazazdr2.nsf/Search?SearchView&Query=(%5BSIREZIZD%5D=17)&SearchOrder=4&SearchMax=301.

Langley PC. The prevalence, correlates and treatment of pain in the European Union. Curr Med Res Opin 2011;27(2):463-80.

Kloosterboer SM, McGuire T, Deckx L, Moses G, Ver-heij T, van Driel ML. Self-medication for cough and the common cold: information needs of consumers. Aust Fam Physician 2015;44(7):497-501.

Bond C, Hannaford P. Issues related to monitoring the safety of over-the-counter (OTC) medicines. Drug Saf 2003;26(15):10674.

Wróblewski T, Kobryń K, Kozieł S, et al. Acetaminop-hen (Paracetamol) induced acute liver failure - A social problem in an era of increasing tendency to self-treat-ment. Ann Agric Environ Med 2015;22(4):762-7667.

Ogawa R, Echizen H. Clinically significant drug intera-ctions with antacids: an update. Drugs 2011;71(14):1839-64.

Moore N, Pollack C, Butkerait P. Adverse drug reac-tions and drug-drug interactions with over-the-counter NSAIDs. Ther Clin Risk Manag 2015;11:1061-75.

Dimitrijević M, Djordjević-Catić A, Stefanović N, Pav-lović D, Veličković-Radovanović R. Self-medication in primary healthcare in the territory of the city of Niš. Acta Medica Medianae 2014; 53(3):19-24.

Schillemans S, De Loof H, De Meyer GR. [Critical eva-luation of interaction screening software available in pharmacies]. J Pharm Belg 2012;(4):4-13.

Pedersen M, Brabrand M. One fourth of acutely admit-ted patients use over-the-counter-drugs 24 hours prior to hospitalisation. Dan Med J 2014;61(2):A4789.

Klemenc-Ketis Z, Kersnik J. Sources and predictors of home-kept prescription drugs. Int J Clin Pharmacol Ther 2010;48(11):705-7.

Gallagher M, Hares T, Spencer J, Bradshaw C, Webb I. The nominal grouptechnique: a research tool for general practice? Fam Pract 1993 Mar;10(1):76-81.

Janković SM. Struktura dizajna (plana) istraživanja. In: Janković SM. Dizajn istraživanja. 1st ed. Kragujevac: Medicinsko društvo za racionalnu terapiju Republike Srbije – Medrat, 2016: 129-32.

Veiga P, Lapão LV, Cavaco AM, Guerreiro MP. Quality supply of nonprescription medicines in Portu-guese community pharmacy: An exploratory case study. Res Social Adm Pharm 2015;11(6):880-90.

Raynor DK, Dickinson R, Knapp P, Long AF, Nicolson DJ. Buyer beware? Does the information provided with herbal products available over the counter enable safe use? BMC Med 2011;9:94.

Halila GC, Junior EH, Otuki MF, Correr CJ. The practi-ce of OTC counseling by community pharmacists in Parana, Brazil. Pharmacy Practice 2015;13(4):597.

Shilbayeh SA. Exploring knowledge and attitudes towards counselling about vitamin supplements in Jor-danian community pharmacies. Pharm Pract (Granada) 2011;9(4):242-51.

Atayee RS, Singh RF, Best BM, Freedman BA, Morello CM. An active-learning assignment involving peer-to-peer presentations to improve pharmacy stu-dents' attitudes and knowledge of dietary supplements. Am J Pharm Educ 2012;76(6):113.

Kwan D, Boon HS, Hirschkorn K, et al. Exploring con-sumer and pharmacist views on the professional role of the pharmacist with respect to natural health products: a study of focus groups. BMC Complement Altern Med 2008;8:40.

Scarton LA, Del Fiol G, Treitler-Zeng Q. Completeness, accuracy, and presentation of information on interactions between prescription drugs and alternative medicines: an internet review. Stud Health Technol Inform 2013;192:841-5.

Faerber AE, Kreling DH. Content analysis of false and misleading claims in television advertising for pre-scription and nonprescription drugs. J Gen Intern Med 2014;29(1):110-8.

Gastelurrutia MA, Benrimoj SI, Castrillon CC, de Ame-zua MJ, Fernandez-Llimos F, Faus MJ. Facilitators for practice change in Spanish community pharmacy. Pharm World Sci 2009;31(1):32-9.

Kooy MJ, Dessing WS, Kroodsma EF, et al. Frequency, nature and determinants of pharmaceutical consultations provided in private by Dutch community pharmacists. Pharm World Sci 2007;29(2):81-9.

Garrard J, Harms S, Eberly LE, Matiak A. Variations in product choices of frequently purchased herbs: caveat emptor. Arch Intern Med 2003;163:2290–2295.

Hämmerlein A, Griese N, Schulz M. Survey of drug-related problems identifiedby community pharmacies. Ann Pharmacother 2007;41(11):1825-32.

Day RO, Snowden L. Where to find information about drugs. Aust Prescr 2016;39(3):88-95.

Thomson Reuters (Healthcare) Inc. MICROMEDEX Gateway. Посећено у мају 2017. године на: www.thomsonhc.com/home/dispatch.

Epocrates, Inc. Interaction Checker. Посећено у мају 2017. године на: https://online.epocrates.com/ interaction-check.

Medscape. Multi-Drug Interaction checker. Посећено у мају 2017. године на: http://reference.medscape.com/drug-interactionchecker.