A COMPARATIVE STUDY OF MELATONIN WITH PLACEBO IN ATTENUATION OF HEMODYNAMIC RESPONSES TO LARYNGOSCOPY AND INTUBATION

Preeti  Jamwal; Zulfiqar Ali; Mohinder Singh  Chib; Deepika  Jamwal; Iqra Nazir; Abdul Qayoom Lone; Sajad Aarif

doi:10.5937/sanamed19-49613

Preeti Jamwal Government Medical College Kathua, Department of Anaesthesiology, Jammu and Kashmir, India
Zulfiqar Ali Sheri Kashmir Institute of Medical Sciences Soura, Department of Anaesthesiology, Jammu and Kashmir, India
Mohinder Singh Chib Gupta Hospital and Research Centre Kathua, Department of Orthopaedics, Jammu and Kashmir, India
Deepika Jamwal Government Medical College Kathua, Department of Gynaecology, Jammu and Kashmir, India
Iqra Nazir Sheri Kashmir Institute of Medical Sciences Soura, Department of Anaesthesiology, Jammu and Kashmir, India
Abdul Qayoom Lone Government Medical College Handwara, Jammu and Kashmir, India
Sajad Aarif Sheri Kashmir Institute of Medical Sciences Soura, Department of Neurosurgery, Jammu and Kashmir, India

DOI: https://doi.org/10.5937/sanamed19-49613

Keywords: Laryngoscopy, pressor response, melatonin, pre-operative anxiety, hemodynamic changes

Abstract

Introduction: An increase in blood pressure and heart rate is observed during laryngoscopy and insertion of the endotracheal tube. Melatonin is used for sedation in the Intensive Care Unit. Our study was based on the hypothesis that administrating 3 mg and 6 mg of melatonin 90 minutes before induction attenuates hemodynamic responses encountered during laryngoscopy and intubation.

Materials and Methods: Seventy-five adult patients scheduled for elective surgical procedures, ASA I and II, were assigned into 3 groups (25 patients in each group) to receive oral placebo, melatonin 3 mg, or melatonin 6 mg 90 minutes prior to induction of anesthesia. Hemodynamic variables were recorded at baseline, before induction, and at 3, 6, 9, 12, 15, and 30 minutes after induction. Analysis of variance (ANOVA) was used for intergroup analysis of data. Categorical variables were compared using non-parametric tests like the Chi-square test or Fisher’s exact test. Bonferroni correction was applied for intergroup analysis. Statistical significance was considered when p < 0.05. Results: An increase in heart rate and blood pressure at 3, 6, and 9 minutes after induction of general anesthesia was observed in the control group compared to the melatonin 3 mg and 6 mg groups administered 90 minutes prior to induction. Oral administration of 6 mg of melatonin was found to provide greater attenuation than 3 mg of melatonin.

Conclusion: Oral administration of 3 mg and 6 mg melatonin effectively attenuates the hemodynamic pressor changes observed during laryngoscopy and tracheal intubation.

Author Biographies

Preeti Jamwal, Government Medical College Kathua, Department of Anaesthesiology, Jammu and Kashmir, India

ORCID: 0000-0002-9292-0765

Zulfiqar Ali, Sheri Kashmir Institute of Medical Sciences Soura, Department of Anaesthesiology, Jammu and Kashmir, India

ORCID: 0000-0002-3870-3137

Mohinder Singh Chib, Gupta Hospital and Research Centre Kathua, Department of Orthopaedics, Jammu and Kashmir, India

ORCID: 0000-0001-5427-6959

Deepika Jamwal, Government Medical College Kathua, Department of Gynaecology, Jammu and Kashmir, India

ORCID: 0009-0007-9763-5385

Iqra Nazir, Sheri Kashmir Institute of Medical Sciences Soura, Department of Anaesthesiology, Jammu and Kashmir, India

ORCID: 0009-0008-3535-5158

Abdul Qayoom Lone, Government Medical College Handwara, Jammu and Kashmir, India

ORCID: 0009-0007-2893-3047

Sajad Aarif, Sheri Kashmir Institute of Medical Sciences Soura, Department of Neurosurgery, Jammu and Kashmir, India

ORCID:0000-0001-9648-0181

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