HAEMATOLOGICAL VARIATIONS ASSOCIATED WITH ALCOHOL CONSUMPTION IN A NIGERIAN UNIVERSITY COMMUNITY

Joyce Etura; Kisamhar Andrew; Uwem Akpan; Zaccheaus Jeremiah

doi:10.5937/sanamed0-51524

Joyce Etura University of Calabar, Faculty of Medical Laboratory Science, Department of Haematology and Blood Transfusion Science, Calabar, Nigeria
Kisamhar Andrew University of Calabar, Faculty of Medical Laboratory Science, Department of Haematology and Blood Transfusion Science, Calabar, Nigeria
Uwem Akpan University of Calabar, Faculty of Medical Laboratory Science, Department of Clinical Chemistry and Immunology, Calabar, Nigeria
Zaccheaus Jeremiah Rivers State University, Faculty of Medical Laboratory Science, Department of Haematology and Blood Transfusion Science, Port Harcourt, Nigeria

DOI: https://doi.org/10.5937/sanamed0-51524

Keywords: Haematology, Alcohol consumers, Platelet count

Abstract

Introduction: Alcohol consumption is widespread, contributing to approximately 3 million deaths worldwide. This study aimed to assess haematological indices among alcohol consumers compared to non-consumers in the University of Calabar Community, Nigeria.

Materials and Methods: This case-control study enrolled 100 subjects (50 alcohol consumers and 50 non-consumers) from the University of Calabar community. Blood samples were collected aseptically for Full Blood Count and Thrombin Time analysis. Rigorous study design, meticulous data collection, and thorough analysis ensured the reliability of our findings.

Results: The mean corpuscular volume (MCV)(76.21±7.35 fl), mean corpuscular haemoglobin (MCH)(25.31±3.26 pg), Platelet (PLT)(154.38±54.89 x 10⁹) and Platelet Crit (PCT)(0.14±0.04%) of alcohol consumers were significantly lower than that of the controls respectively (79.36±5.76 fl, 26.47± 2.15 pg, 187.22± 58.34 x 10⁹and 0.17±0.04%)(p<0.05). At the same time, the red cells distribution width (RDWCV), Platelet distribution width (PDW), and thrombin time (TT) varied significantly among alcohol consumers (15.14±1.05%, 14.91±0.43fl and 15.22±2.53s) respectively than in the controls(14.74±0.95%, 14.76±0.29fl and 12.70±1.52s). Other parameters were comparable (p>0.05) between the two groups of subjects studied. A significant negative correlation (r=0.801, p=0.001) was observed between Thrombin time and Plateletcrit in the test subjects. In contrast, a significant positive correlation (r=0.698, p=0.001) was observed between Mean Corpuscular Haemoglobin Concentration and Haemoglobin in alcohol consumption. A significant negative correlation (r=0.973, p=0.001) was observed between lymphocytes and granulocytes in percentage in the test subjects. These significant findings provide valuable insights into the haematological variations associated with alcohol consumption.

Conclusion: These significant differences observed in this study underscore the impact of alcohol consumption on haematological indices. The study concluded that derangements in some hematological parameters occur in alcoholics, which can affect their quality of life.

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