Surgical treatment of colorectal cancer metastases
Abstract
Background/Aim: Colorectal metastatic liver tumours are the most common secondary liver tumours. During the life of patients with colorectal tumorous, this liver metastases will develop either synchronously or metachronously in half of the patients. Approximately 25 % of patients with colorectal cancer diagnosis have secondary deposits in the liver and the additional 25 % of patients will develop metastases within five years. The objective was to investigate whether anatomic resections of the liver present a method of choice in surgical treatment of colorectal liver metastases compared to metastasectomy surgery.
Methods: A total of 65 patients were divided into two groups. Patients in the first group underwent metastasectomies consisting in the removal of metastases and the surrounding liver parenchyma no more than 1 cm by Kelly clamp crushing technique or LigaSure vessel-sealing system. Patients in the second group were subjected to the anatomic resection of the liver where not only metastases were removed, but also the associated anatomical segment or section or half the liver, depending on the number and localisation of metastases.
Results: The mean values (± standard deviation) of the overall survival for the first and the second group were 36 ± 4.8 months and 36 ± 2.6 months, respectively. The mean values (± standard deviation) of the disease-free survival in the first and in the second group were 18 ± 2.22 months and 22 ± 0.74 months, respectively. None of the found inter-group differences were statistically significant.
Conclusion: It can be concluded that metastatic surgery for colorectal liver metastases and anatomic resections have almost the same results and are irreplaceable methods in the treatment of colorectal liver metastases.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).