Significance of dyspnoea as a symptom in the emergency department of the primary healthcare centre

  • Žana M Maksimović Dom zdravlja Modriča, Služba hitne medicinske pomoći; Medicinski fakultet Banja Luka, Centar za biomedicinska istraživanja
  • Nada Banjac Emergency Care Deparment, Primary Healthcare Centre Banja Luka, Republic of Srpska, Bosnia and Herzegovina; Department of Emergency Medicine, Faculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina
  • Miloš Čović Emergency Care Deparment, Primary Healthcare Centre Banja Luka, Republic of Srpska, Bosnia and Herzegovina
Keywords: Dyspnoea, Emergency department, Primary healthcare centre, Differential diagnosis

Abstract


Background/Aim: Dyspnoea represents a subjective feeling of laboured breathing of different intensity. The aim of this study was to determine how often patients come with dyspnoea to a local Emergency Department of the Primary Healthcare Centre (EDPHC) and to analyse the assumed aetiology, diagnostics and therapy of the dyspnoeic patients.

Methods: The records of the EDPHC of the City of Banja Luka for the period between 1 October 2019 to 31 December 2019 of all patients older than 15 years of age that have reported laboured breathing were identified and analysed. Following parameters were recorded: age, gender, diagnostics performed, administered therapy, whether the patient was examined in the field or in the ambulance, as well as whether the patient was referred to a hospital (Cardiology, Pulmonology or another department) or not.

Results: Laboured breathing was reported by 665 patients. Out of this number, 108 patients were examined by their family doctor, 407 patients in EDPHC ambulance and 150 patients in the field. The average age of the patient was 61.03 ± 19.17, with an equal distribution in males and females. The aetiology of dyspnoea was cardiac and pulmonary in one-third of patients each, whereas the diagnosis in the other patients was versatile, from anxiety disorders, musculoskeletal diseases and active malignancy to unspecified chest pain that could not receive a definitive diagnosis. One half of the patients (N = 261 or 46.86 %) was completely taken care of in the ambulance or in the field, 199 (35.73 %) patients were sent to a cardiologist, 87 (15.62 %) to a pulmonologist and 10 (1.80 %) of patients to another specialist. Referral to hospital was registered more often in men (χ 2 = 9.195, p = 0.027), elderly (χ 2 = 53.29, p < 0.001), people with lower peripheral oxygen saturation (SpO 2 ) (χ 2 = 120.61, p < 0.001) and people with significant deviation of normal blood pressure values (χ 2 =120.61, p < 0.001).

Conclusion: Dyspnoea can be caused by an array of different diseases and more than one diagnostic method is necessary to confirm/exclude any of the most common causes of dyspnoea. A broader diagnostical palette in ED would be preferred for purposes of ascertaining a timely diagnosis.

References

1. American Thoracic Society. Dyspnea. Mechanisms, assessment and management: a consensus statement. Am J Respir Crit Care Med 1999 Jan;159(1):321–40.
2. Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, et al. An official Thoracic Society statement: update on the mechanism, assessment and management of dyspnea. Am J Respir Crit Care Med 2012 Feb 15;185(4):435–52.
3. Banzett RB, Lansing RW, Reid MB, Adams L, Brown R. ‘Air hunger’ arising from increased PCO2 in mechanically ventilated quadriplegics. Respir Physiol 1989 Apr;76(1):53–67.
4. Lansing RW, Gracely RH, Banzett RB. The multiple dimensions of dyspnea: review and hypotheses. Respir Physiol Neurobiol 2009 May 30;167(1):53–60.
5. Currow DC, Plummer JL, Crockett A, Abernethy AP. A community population survey of prevalence and severity of dyspnea in adults. J Pain Symptom Manage 2009 Oct;38(4):533–45.
6. Grønseth R, Vollmer WM, Hardie JA, Ólafsdóttir IS, Lamprecht B, Buist AS, et al. Predictors of dyspnoea prevalence: results from the BOLD study. Eur Respir J 2014 Jun;43(6):1610–20.
7. Nishimura K, Izumi T, Tsukino M, Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002 May;121(5):1434–40.
8. Abidov A, Rozanski A, Hachamovitch R, Hayes SW, Aboul-Enein F, Cohen I, et al. Prognostic significance of dyspnea in patients referred for cardiac stress testing. N Engl J Med 2005 Nov 3;353(18):1889–98.
9. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison's principles of internal medicine. 19th edition. United States: McGraw‐Hill; 2015.
10. Huang L, Touray S, Akalin A, Ahmad S. A 54-Year-Old man presenting with progressive dyspnea and interstitial lung abnormalities. Chest 2019 Mar;155(3):e69–e74.
11. Staubach S, Strohm H, Mudra H. Progressive dyspnea and signs of right heart dysfunction. Echocardiography 2017 Jan;34(1):119-121.
12. Moniodis AE, Ginns JN, Systrom DM. Dyspnea and an arteriovenous fistula. Ann Am Thorac Soc 2016 Aug;13(8):1419-23.
13. Agrawal A, Sikachi RR, Koenig S, Khanijo S. A 68-Year-Old man with dyspnea on exertion and cough. Chest 2018 Jun;153(6):e139–e145. doi: 10.1016/j.chest.2018.02.030.
14. Türkoğlu Eİ, Yavuzgil O. A rare cause of dyspnea: Left atrial angiosarcoma. Anatol J Cardiol 2019 Aug;22(2):96-98.
15. Wang B, Ma D, Qu L, Cao D, Man X. Sinus of Valsalva aneurysm protruding into the mitral anterior leaflet causing dyspnea: A CARE-compliant case report. Medicine (Baltimore) 2019 Nov;98(48):e18169. doi: 10.1097/MD.0000000000018169.
16. Banzett RB, O’Donnell CR, Guilfoyle TE, Parshall MB, Schwartzstein RM, Meek PM, et al. Multidimensional Dyspnoea Profile (MDP): an instrument for laboratory and clinical research. Eur Respir J 2015 Jun;45(6):1681–91.
17. Williams MT, John D, Frith P. Comparison of the Dyspnoea-12 and Multidimensional Dyspnoea Profile in people with COPD. Eur Respir J 2017 Mar 2;49(3). pii: 1600773. doi: 10.1183/13993003.00773-2016.
18. Perez T, Burgel PR, Paillasseur JL, Caillaud D, Deslée G, Chanez P, et al. Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2015 Aug 18;10:1663-72.
19. Hashimoto H, Kanda K. Development and validation of the Total Dyspnea Scale for Cancer Patients. Eur J Oncol Nurs 2019 Aug;41:120-125.
20. Laviolette L, Laveneziana P; ERS Research Seminar Faculty. Dyspnoea: a multidimensional and multidisciplinary approach. Eur Respir J 2014 Jun;43(6):1750-62.
21. Boulding R, Stacey R, Niven R, Fowler SJ. Dysfunctional breathing: a review of the literature and proposal for classification. Eur Respir Rev 2016 Sep;25(141):287-94.
22. Yernault J. Dyspnea in the elderly: a clinical approach to diagnosis. Drugs Aging 2001;18(3):177-87.
23. Thomas P. ‘I can’t breathe’: assessment and emergency management of acute dyspnea. Aust Fam Physician 2005 Jul;34(7):523–9.
24. Obokata M, Olson TP, Reddy YNV, Melenovsky V, Kane GC, Borlaug BA. Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction. Eur Heart J 2018 Aug 7;39(30):2810–2821.
25. Makdee O, Monsomboon A, Surabenjawong U, Praphruetkit N, Chaisirin W, Chakorn T, et al. High-flow nasal cannula versus conventional oxygen therapy in emergency department patients with cardiogenic pulmonary edema: A randomized controlled trial. Ann Emerg Med 2017 Oct;70(4):465-472.e2.
26. Giezeman M, Hasselgren M, Lisspers K, Ställberg B, Montgomery S, Janson C, et al. Influence of comorbid heart disease on dyspnea and health status in patients with COPD – a cohort study. Int J Chron Obstruct Pulmon Dis 2018 Nov 28;13:3857-65.
27. O’Donnell DE, James MD, Milne KM, Neder JA. The pathophysiology of dyspnea and exercise intolerance in chronic obstructive pulmonary disease. Clin Chest Med 2019 Jun;40(2):343–366.
28. Hasegawa K, Sullivan AF, Tovar Hirashima E, Gaeta TJ, Fee C, Turner SJ, et al. A multicenter observational study of US adults with acute asthma: Who are the frequent users of the emergency department? J Allergy Clin Immunol Pract 2014 Nov-Dec;2(6):733–40.
29. Kuan WS, Craig S, Kelly AM, Keijzers G, Klim S, Graham CA, et al. Asthma among adult patients presenting with dyspnea to the emergency department: An observational study. Clin Respir J 2018 Jun;12(6):2117–2125.
30. Lippi G, Sanchis-Gomar F, Cervellin G. Chest pain, dyspnea and other symptoms in patients with type 1 and 2 myocardial infarction. A literature review. Int J Cardiol 2016 Jul 15;215:20–22.
31. Koutsampasopoulos K, Grigoriadis S, Vogiatzis I. Exertional dyspnea after myocardial infarction: thinking beyond the diagnosis of heart failure. J Int Med Res 2018 Nov;46(11):4769-4774.
32. Bhatia S, Sims JR, Anavekar NS. 75-Year-Old man with chest pain and dyspnea. Mayo Clin Proc 2019 Feb;94(2):341-346.
33. Kupper N, Bonhof C, Westerhuis B, Widdershoven J, Denollet J. Determinants of dyspnea in chronic heart failure. J Card Fail 2016 Mar;22(3):201-9.
34. Miner B, Tinetti ME, Van Ness PH, Han L, Leo-Summers L, Newman AB, et al. Dyspnea in community-dwelling older persons: a multifactorial geriatric health condition. J Am Geriatr Soc 2016 Oct;64(10):2042-2050.
35. Wong MFK, Leung MWM, Leung CM. 'Organic anxiety' in a middle-aged man presenting with dyspnoea: a case report. East Asian Arch Psychiatry 2019 Sep;29(3):97-98.
36. Fan X, Meng Z. The mutual association between depressive symptoms and dyspnea in Chinese patients with chronic heart failure. Eur J Cardiovasc Nurs 2015 Aug;14(4):310–316.
37. Renier W, Winckelmann KH, Verbakel JY, Aertgeerts B, Buntinx F. Signs and symptoms in adult patients with acute dyspnea: a systematic review and meta-analysis. Eur J Emerg Med 2018 Feb;25(1):3–11.
38. Hadžić R, Maksimović ŽM, Stajić M, Lončar-Stojiljković D. D-dimer: a role in ruling out pulmonary embolism in an emergency care department. Scr Med 2020;51(1):28-33.
39. Ramalho SHR, Santos M, Claggett B, Matsushita K, Kitzman DW, Loehr L, et al. Association of undifferentiated dyspnea in late life with cardiovascular and noncardiovascular dysfunction. A cross-sectional analysis from the ARIC study. JAMA Netw Open 2019 Jun 5;2(6):e195321. doi: 10.1001/jamanetworkopen.2019.5321.
40. Bello NA, Cheng S, Claggett B, Shah AM, Ndumele CE, Roca GQ, et al. Association of weight and body composition on cardiac structure and function in the ARIC Study (Atherosclerosis Risk in Communities). Circ Heart Fail 2016 Aug;9(8). pii: e002978. doi: 10.1161/CIRCHEARTFAILURE.115.002978.
Published
2020/09/30
Section
Original article