Evaluation of associations of GSTM1/GSTT1 null genotypes with the susceptibility to age-related macular degeneration, a meta-analysis
GSTT1/GSTM1 polymorphisms and ARMD
Keywords:
GSTM1, GSTT1, Age-related macular degeneration, Meta-analysis
Abstract
Background: The relationship between glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null genotypes (homozygotes for the null alleles) and the susceptibility to age-related macular degeneration (ARMD) have been reported and revealed inconsistent results. Therefore, the current meta-analysis was carried out.
Methods: Eligible published articles (before December 2020) were found by searching 8 databases. The data was extracted from articles. The heterogeneity across studies was estimated using Q and I2 statistics and the odds ratios (ORs) and its 95 % confidence intervals (95 % CI) were estimated.
Results: In total, 6 independent studies including 1089 participants (634 controls and 455 patients) were used in the current study. There was no heterogeneity between studies for both polymorphisms. Statistical analysis showed that the null genotypes of the GSTM1 (OR = 1.18, 95 % CI: 0.91 - 1.53, p = 0.191) and GSTT1 (OR = 0.84, 95 % CI: 0.60 - 1.18, p = 0.328) loci were not correlated with the susceptibility to ARMD.
Conclusion: The GSTT1 and GSTM1 genetic polymorphisms did not associated with the risk of ARMD in Caucasian populations.
References
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17. Hunter AA 3rd, Smit-McBride Z, Anderson R, Bordbari MH, Ying GS, Kim ES, Park SS, Telander DG, Dunaief JL, Hjelmeland LM, Morse LS. GSTM1 and GSTM5 genetic polymorphisms and expression in age-related macular degeneration. Curr Eye Res. 2016;41:410-416.
18. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-748.
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2. Nita M, Grzybowski A. The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. 2016;2016:3164734.
4. Tisi A, Feligioni M, Passacantando M, Ciancaglini M, Maccarone R. The impact of oxidative stress on blood-retinal barrier physiology in age-related macular degeneration. Cells. 2021;10:E64.
3. Jarrett SG, Boulton ME. Consequences of oxidative stress in age-related macular degeneration. Mol Aspects Med. 2012;33:399-417.
5. Su X, Ren Y, Li M, Kong L, Kang J. Association of glutathione S-transferase M1 and T1 genotypes with asthma: A meta-analysis. Medicine (Baltimore). 2020;99:e21732.
6. Liu T, Liu WZ, Sun Y, Bi XH, Zhou HF. An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer. J Cancer Res Ther. 2020;16:718-725.
7. Cui JP, Lin MY, Liu ZH, Liu BL. Association between GSTT1 homozygous deletion and risk of pancreatic cancer: A meta-analysis. Chin Med Sci J. 2019;34:205-210.
8. Zhou YJ, Zhao BL, Qian Z, Xu Y, Ding YQ. Association of glutathione S-transferase M1 null genotype with inflammatory bowel diseases: A systematic review and meta-analysis. Medicine (Baltimore). 2019;98:e17722.
9. Wang J, Wu D, Sun A. Effects of GST null genotypes on individual susceptibility to leukemia: A meta-analysis. Exp Mol Pathol. 2019;108:137-142.
10. Sun W, Su L, Sheng Y, Shen Y, Chen G. Is there association between glutathione S transferases polymorphisms and cataract risk: a meta-analysis? BMC Ophthalmol. 2015;15:84.
11. Lu Y, Shi Y, Yin J, Huang Z. Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis. Gene. 2013;527:311-315.
12. Yu Y, Weng Y, Guo J, Chen G, Yao K. Association of glutathione S transferases polymorphisms with glaucoma: a meta-analysis. PLoS One. 2013;8:e54037.
13. Oz O, Aras Ates N, Tamer L, Yildirim O, Adigüzel U. Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Eur J Ophthalmol, 2006;16:105-110.
14. Güven M, Görgün E, Ünal M, Yenerel M, Batar B, Küçümen B, Dinç UA, Güven GS, Ulus T, Yüksel A. Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration. Ophthalmic Res. 2011;46:31-37.
15. Liu MM, Agrón E, Chew E, Meyerle C, Ferris FL 3rd, Chan CC, Tuo J. Copy number variations in candidate genes in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:3129-3135.
16. Othman H, Gholampour AR, Saadat I, Farvardin-Jahromoi M, Saadat M. Age related macular degeneration and genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1). Mol Biol Rep. 2012;39:3299-3303.
17. Hunter AA 3rd, Smit-McBride Z, Anderson R, Bordbari MH, Ying GS, Kim ES, Park SS, Telander DG, Dunaief JL, Hjelmeland LM, Morse LS. GSTM1 and GSTM5 genetic polymorphisms and expression in age-related macular degeneration. Curr Eye Res. 2016;41:410-416.
18. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719-748.
19. Saadat M. Null genotypes of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms increased susceptibility to type 2 diabetes mellitus, a meta-analysis. Gene. 2013;532:160-162.
20. Saadat M. Genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and susceptibility to gastric cancer: a meta-analysis. Cancer Sci. 2066;97:505-509.
21. Saadat M. Apolipoprotein E (APOE) polymorphisms and susceptibility to breast cancer: A meta-analysis. Cancer Res Treat. 2012;44:121-126.
22. Saadat M. Haplotype analysis of XRCC1 (at codons 194 and 399) and susceptibility to breast cancer, a meta-analysis of the literatures. Breast Cancer Res Treat. 2010;124:785-791.
Published
2021/03/26
Section
Original article
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