Cutaneous side effects during therapy with erlotinib - case report

Erlotinib case report

  • Sanja Jovičić MD
  • Vesna Gajanin
  • Sanja Umičević Šipka
Keywords: Erlotinib, Tyrosine kinase inhibitors, Dermato-toxicity

Abstract


Erlotinib is an antineoplastic drug used in the treatment of non-small cell lung cancer and pancreatic cancer. It is a potent, selective inhibitor of tyrosine kinase, a receptor for epidermal growth factor receptor (EGFR). Cutaneous side effects such as acneiform eruption, xerosis, telangiectasia, hair and nail changes are common. A case of a 70-year-old patient who developed unusual cutaneous side effects after 6 years of treatment with erlotinib was presented.

References

1. Sabbah DA, Hajjo R, Sweidan K. Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors. Curr Top Med Chem 2020;20(10):815-34.
2. Chen KL, Lin CC, Cho YT, Yang CW, Sheen YS, Tsai HE, et al. Comparison of skin toxic effects associated with gefitinib, erlotinib, or afatinib treatment for non-small cell lung cancer. JAMA Dermatol 2016;152(3):340-2.
3. Julian I, Iwamoto T. Investigation of biomarkers and handling strategy of erlotinib-induced skin rash in rats. Biol Pharm Bull 2021;44(8):1050-9.
4. Carlesimo M, Pigliacelli F, D'Arino A, Caro G, Fortuna MC, Rossi A. Dermatologic management of oncotherapy side effects: a proposed algorithm. J Cosmet Dermatol 2021;20(2):429-36.
5. Kiyohara Y, Yamazaki N, Kishi A. Erlotinib-related skin toxicities: treatment strategies in patients with metastatic non-small cell lung cancer. J Am Acad Dermatol 2013;69(3):463-72.
6. Macdonald JB, Macdonald B, Golitz LE, LoRusso P, Sekulic A. Cutaneous adverse effects of targeted therapies: Part I: Inhibitors of the cellular membrane. J Am Acad Dermatol 2015;72(2):203-18.
7. Hirsh V. Managing treatment-related adverse events associated with egfr tyrosine kinase inhibitors in advanced non-small-cell lung cancer. Curr Oncol 2011;18(3):126-38.
8. Saif MW, Merikas I, Tsimboukis S, Syrigos K. Erlotinib-induced skin rash. Pathogenesis, clinical significance and management in pancreatic cancer patients. JOP 2008;9(3):267-74.
9. Patrizi A, Bianchi F, Neri I. Rosaceiform eruption induced by erlotinib. Dermatol Ther 2008;21 Suppl 2:S43-5.
10. Komiya N, Takahashi K, Kato G, Kubota M, Tashiro H, Nakashima C, et al. Acute generalized exanthematous pustulosis caused by erlotinib in a patient with lung cancer. Case Rep Oncol 2021;14(1):599-603.
11. Pérez-Soler R. Can rash associated with HER1/EGFR inhibition be used as a marker of treatment outcome? Oncology (Williston Park) 2003;17(11 Suppl 12):23-8.
12. Wacker B, Nagrani T, Weinberg J, Witt K, Clark G, Cagnoni PJ. Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res 2007;13(13):3913-21.
13. Julian I, Iwamoto T. Investigation of biomarkers and handling strategy of erlotinib-induced skin rash in rats. Biol Pharm Bull 2021;44(8):1050-9.

Published
2021/12/31
Section
Case report