Allergic Contact Dermatitis Caused by Dexpanthenol Confirmed With Open Application Test: a Case Report
Abstract
Topical medications and cosmetic products contain many allergens that can trigger allergic contact dermatitis. One of the most frequent ingredients is dexpanthenol (bepanthen, panthenol). A case of a 19-year-old female patient is presented, with a 2-year history of continuous episodes of contact allergic reactions with positive open application test to dexpanthenol, after other dermatoses and allergens were excluded.
References
Peiser M, Tralau T, Heidler J, Api AM, Arts JH, Basketter DA, et al. Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany. Cell Mol Life Sci 2012 Mar;69(5):763-81.
Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE. Contact allergy and allergic contact dermatitis in adolescents: prevalence measures and associations. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). Acta Derm Venereol 2002;82(5):352-8.
Hannuksela M, Salo H. The repeated open application test (ROAT). Contact Dermatitis 1986;14(4):221-7.
Stables GI, Wilkinson SM. Allergic contact dermatitis due to panthenol. Contact Dermatitis 1998;38(4):236-7.
Chin MF, Hughes TM, Stone NM. Allergic contact dermatitis caused by panthenol in a child: allergic contact dermatitis caused by panthenol. Contact Dermatitis 2013;69(5):321-2.
Bregnbak D, Johansen JD, Zachariae C. Contact dermatitis caused by panthenol used for aftercare treatment of a new tattoo: contact dermatitis caused by dexpanthenol. Contact Dermatitis 2016;75(1):50-2.
Nguyen HL, Yiannias JA. Contact dermatitis to medications and skin products. Clin Rev Allergy Immunol 2019;56(1):41-59.
Fernandes S, Macias V, Cravo M, Amaro C, Santos R, Cardoso J. Allergic contact dermatitis caused by dexpanthenol: report of two cases. Contact Dermatitis 2012;66(3):160-1.
Keilig W. Contact allergy to dexpanthenol. Derm Beruf Umwelt 1987;35(6):206-8.
Hemmer W, Bracun R, Wolf-Abdolvahab S, Focke M, Götz M, Jarisch R. Maintenance of hand eczema by oral pantothenic acid in a patient sensitized to dexpanthenol. Contact Dermatitis 1997;37(1):51. doi:10.1111/j.1600-0536.1997.tb00389.x.
Gulec AI, Albayrak H, Uslu E, Başkan E, Aliagaoglu C. Pustular irritant contact dermatitis caused by dexpanthenol in a child. Cutan Ocul Toxicol 2015;34(1):75-6.
Han J, Warshaw EM. Allergic contact dermatitis to panthenol in "hypoallergenic" products. Dermatitis 2022 Mar 22. doi: 10.1097/DER.0000000000000883.
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).