Evaluating the Outcome of Distal Sodium Channel Block by Chennai Cocktail Composition in Active Phase (Stage 1) of Adhesive Capsulitis (Frozen Shoulder)

  • Mruthyunjaya Talak Doddabasappa Professor And Hod Dept Orthopaedics, Sri Siddartha Institute Of Medical Sciences And Research Centre, t. Begur, Bangalore Rural, Karnataka https://orcid.org/0009-0003-8700-9365
  • Harish Ugrappa Associate Professor, Dept Orthopaedics, Sri Siddartha Institute Of Medical Sciences And Research Centre, t. Begur, Bangalore Rural, Karnataka https://orcid.org/0009-0003-8700-9365
  • Roshan Iqbal Assistant Professor, Dept Orthopaedics, Sri Siddartha Institute Of Medical Sciences And Research Centre, t. Begur, Bangalore Rural, Karnataka https://orcid.org/0009-0003-8700-9365
  • Bharathkrishna Sanchi Assistant Professor, Dept Orthopaedics, Sri Siddartha Institute Of Medical Sciences And Research Centre, t. Begur, Bangalore Rural, Karnataka https://orcid.org/0009-0003-1199-3407
  • Akash Kumar Senior Resident , Dept Of Orthopaedics, Sri Siddartha Institute Of Medical Sciences And Research Centre, t. Begur, Bangalore Rural, Karnataka https://orcid.org/0009-0004-2912-0804
Keywords: Bursitis, Adhesive capsulitis, Coracohumeral ligament (CHL), Chennai cocktail method, Range of motion, articular (ROM), Receptors, alpha-2

Abstract


Background/Aim: The average age range for people with adhesive capsulitis, also referred to as frozen shoulder, is 40–70 years old. Diffuse, severe shoulder pain gradually develops; it usually gets worse at night and causes a progressive loss of range of motion (ROM), particularly external rotation. In the treatment of adhesive capsulitis, distal sodium channel block by the Chennai Cocktail Method has become popular. It works by apparently activating alpha-2 receptors and blocking distal sodium channels, which reduces pain and promotes healing with a low risk of infections and immune reactions. Aim of this study was to evaluate efficacy of this method in patients with adhesive capsulitis.

Methods: Chennai cocktail regime consisted of two millilitres (mL) of 2 % lidocaine hydrochloride + 1 mL of 40 mg/mL triamcinolone injection + 30 μg clonidine injection. Prior consent to be taken from the patient before the procedure. Xylocaine, clonidine and steroid test dose were given half an hour before the procedure After the skin was marked, under aseptic precautions parts were painted and draped with a hole towel. Chennai cocktail regime was injected into 1st web space of the affected upper limb.

Results: Internal rotation showed the most improvement, while abduction and external rotation showed the fastest and most noticeable recovery. At six weeks and three months, there was a considerable recovery (p < 0.05) in abduction and external rotation. Flexion, abduction and external rotation did not significantly improve at two weeks. The group's SPADI pain and disability scores significantly improved at six weeks and three months (p < 0.05). Most of the patients were able to return to their normal daily activities and sleep on the affected side without any problems. The VAS showed a significant (p < 0.05) improvement in the group at three months. At three months, flexion, abduction and external rotation all showed a discernible improvement.

Conclusion: Injections using the Chennai Cocktail Method for adhesive capsulitis seem to be a safe and efficient treatment that improves ROM and discomfort in individuals with adhesive capsulitis of the shoulder at short-term follow-up.

 

References

Pandey V, Madi S. Clinical guidelines in the management of frozen shoulder: an update! Indian J Orthop. 2021 Feb 1;55(2):299-309. doi: 10.1007/s43465-021-00351-3.

Dyer BP, Rathod-Mistry T, Burton C, Van Der Windt D, Bucknall M. Diabetes as a risk factor for the onset of frozen shoulder: a systematic review and meta-analysis. BMJ open. 2023 Jan 1;13(1):e062377. doi: 10.1136/bmjopen-2022-062377.

Gainty C. The autobiographical shoulder of Ernest Amory Codman: crafting medical meaning in the twentieth century. Bulletin of the History of Medicine. 2016 Oct 1;90(3):394-423. doi: 10.1353/bhm.2016.0071.

Millar NL, Meakins A, Struyf F, Willmore E, Campbell AL, Kirwan PD, Akbar M, Moore L, Ronquillo JC, Murrell GA, Rodeo SA. Frozen shoulder. Nature reviews Disease primers. 2022 Sep 8;8(1):59. doi: 10.1038/s41572-022-00386-2.

Anjum R, Aggarwal J, Gautam R, Pathak S, Sharma A. Evaluating the outcome of two different regimes in adhesive capsulitis: A prospective clinical study. Medical Principles and Practice. 2020 May 29;29(3):225-30. doi: 10.1159/000503317.

Carette S, Moffet H, Tardif J, Bessette L, Morin F, Frémont P, Bykerk V, Thorne C, Bell M, Bensen W, Blanchette C. Intraarticular corticosteroids, supervised physiotherapy, or a combination of the two in the treatment of adhesive capsulitis of the shoulder: A placebo‐controlled trial. Arthritis & rheumatism. 2003 Mar;48(3):829-38. doi: 10.1002/art.10954.

Fields BK, Skalski MR, Patel DB, White EA, Tomasian A, Gross JS, Matcuk GR. Adhesive capsulitis: review of imaging findings, pathophysiology, clinical presentation, and treatment options. Skeletal radiology. 2019 Aug 1;48:1171-84. doi: 10.1007/s00256-018-3139-6.

Lippmann RK. Frozen shoulder; periarthritis; bicipital tenosynovitis. Archives of Surgery. 1943 Sep 1;47(3):283-96. doi: 10.1001/archsurg.1943.01220150064005.

Thomas WJ, Jenkins EF, Owen JM, Sangster MJ, Kirubanandan R, Beynon C, Woods DA. Treatment of frozen shoulder by manipulation under anaesthetic and injection: does the timing of treatment affect the outcome?. The Journal of Bone & Joint Surgery British Volume. 2011 Oct 1;93(10):1377-81. doi: 10.1302/0301-620X.93B10.27224.

Flannery O, Mullett H, Colville J. Adhesive shoulder capsulitis: does the timing of manipulation influence outcome?. Acta orthopaedica belgica. 2007 Feb 1;73(1):21.PMID: 17441653.

Mertens MG, Meert L, Struyf F, Schwank A, Meeus M. Exercise therapy is effective for improvement in range of motion, function, and pain in patients with frozen shoulder: A systematic review and meta-analysis. Archives of Physical Medicine and Rehabilitation. 2022 May 1;103(5):998-1012. doi: 10.1016/j.apmr.2021.07.806.

Challoumas D, Biddle M, McLean M, Millar NL. Comparison of treatments for frozen shoulder: a systematic review and meta-analysis. JAMA network open. 2020 Dec 1;3(12):e2029581-. doi: 10.1001/jamanetworkopen.2020.29581.

Millar NL, Meakins A, Struyf F, Willmore E, Campbell AL, Kirwan PD, Akbar M, Moore L, Ronquillo JC, Murrell GA, Rodeo SA. Frozen shoulder. Nature reviews Disease primers. 2022 Sep 8;8(1):59. Doi.10.1038/s41572-022-00386-2.

Favejee MM, Koes BW. Frozen shoulder: the effectiveness of conservative and surgical interventions—systematic review. British journal of sports medicine. 2011 Jan 1;45(1):49-56. doi: 10.1136/bjsm.2010.071431.

TTveitå EK, Tariq R, Sesseng S, Juel NG, Bautz-Holter E. Hydrodilatation, corticosteroids and adhesive capsulitis: a randomized controlled trial. BMC musculoskeletal disorders. 2008 Dec;9:1-0. DOI: 10.1186/1471-2474-9-53.

Griesser MJ, Harris JD, Campbell JE, Jones GL. Adhesive capsulitis of the shoulder: a systematic review of the effectiveness of intra-articular corticosteroid injections. JBJS. 2011 Sep 21;93(18):1727-33. doi: 10.2106/JBJS.J.01275.

D'Orsi GM, Via AG, Frizziero A, Oliva F. Treatment of adhesive capsulitis: a review. Muscles Ligaments Tendons J. 2012 Sep 10;2(2):70-8. PMID: 23738277.

Published
2025/12/31
Section
Professional article