Correlation Between Psoriasis Severity and Dyslipidaemia in Iraqi Patients

  • Samar Ahmed Jasim Department of dermatology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Mohammed Abbas Department of dermatology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
  • Ethar Thaer Mustafa Al Iraqiya university - college of medicine
  • Shaymaa Khalid Abdulqader Al-Kindy College of Medicine, University of Baghdad
DOI: https://doi.org/10.5937/scriptamed56-57843

Sažetak


Background/Aim: Psoriasis is a persistent systemic disorder characterised by chronic inflammation and linked to multiple comorbidities, including arthritis, cardiometabolic disorders, obesity and hyperlipidaemia. Objective of this study was to identify the relationship of abnormal lipid profiles and psoriasis, as well as to pinpoint factors that correlate with disease severity.

Patients and methods: A cross-sectional study was carried out at the dermatology clinic over 6 months from the 1 August 2024 to the 1 February 2025. Patients aged 15 years and above with a diagnosis of psoriasis were enrolled. For each patient two sets of data were collected, demographical characteristics (age, sex, disease duration and the body mass index (BMI)) and the lipid profile (total cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL)). The psoriasis severity determined by the Psoriasis Area and Severity Index (PASI) and accordingly, the association between patients' BMI and lipid profile with PASI score were assessed.

Results: A total of 93 psoriasis patients were recruited over the study period. The mean of the patients age was 45.49 ± 10.71 years with about two-thirds of them being females. Severe psoriasis where significantly correlated with BMI and elevated serum levels of TG and TC, LDL and low levels of HDL, p < 0.001. PASI score had a positive significant correlation with each of BMI (p < 0.001), disease duration (p = 0.046), TC (p < 0.001), TG (p < 0.001) and LDL-C (p = 0.003). On the other hand, the PASI score displayed a significant negative correlation with HDL-C (p < 0.001)

Conclusion: A significant association between psoriasis severity and metabolic disturbances, including dyslipidaemia and overweight was found in Iraqi adults with psoriasis.

Reference

Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN. Psoriasis. Lancet. 2021 Apr 3;397(10281):1301-1315. doi: 10.1016/S0140-6736(20)32549-6.

Parisi R, Iskandar IYK, Kontopantelis E, Augustin M, Griffiths CEM, Ashcroft DM. National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study. BMJ. 2020;369. doi: 10.1136/BMJ.M1590.

Armstrong AW, Read C. Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA. 2020;323. doi: 10.1001/jama.2020.4006.

Yadav V, Mendiratta V, Agrawal A, Bisherwal K, Singh R, Meena A. Interleukin levels and non-alcoholic fatty liver disease in chronic plaque psoriasis: An analytical case control study. Indian J Dermatol. 2023;68. doi: 10.4103/ijd.ijd_1015_22.

Liu S, He M, Jiang J, Duan X, Chai B, Zhang J, et al. Triggers for the onset and recurrence of psoriasis: a review and update. Cell Commun Signal. 2024;22. doi: 10.1186/S12964-023-01381-0.

Hassan WNM, Al-Kaabi MM, Akram NN, Kassim MAK, Pantazi AC. Probiotics for inflammatory bowel disease; a deep dive into their impact on disease course and associated health risks. Curr Med Chem. 2024. doi: 10.2174/0109298673314861240429072352.

Kafle M, Gyawlee M, Amatya A, Kayastha BMM, Upadhyaya S. Dyslipidemia in psoriasis: a case - controlled study. Nepal J Dermatol Venereol Leprol. 2021;19. doi: 10.3126/njdvl.v19i2.38556.

Nakhwa YC, Rashmi R, Basavaraj KH. Dyslipidemia in psoriasis: a case controlled study. Int Sch Res Notices. 2014;2014. doi: 10.1155/2014/729157.

Mohammed JQ, Mathkhor AJ, Mardan FT. Dyslipidemia in patients with psoriasis and psoriatic arthritis. Dermatol Res. 2022;4. doi: 10.33425/2690-537x.1026.

Miao C, Li J, Li Y, Zhang X. Obesity and dyslipidemia in patients with psoriasis: A case–control study. Medicine (United States). 2019;98. doi: 10.1097/MD.0000000000016323.

Lea WA, Cornish HH, Block WD. Studies on serum lipids, proteins, and lipoproteins in psoriasis. J Invest Dermatol. 1958;30. doi: 10.1038/jid.1958.34.

Antoniazzi L, Arroyo-Olivares R, Bittencourt MS, Tada MT, Lima I, Jannes CE, et al. Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia. Nutrit Metab Cardiovasc Dis. 2021;31. doi: 10.1016/j.numecd.2021.04.006.

Al-Mutairi N, Al-Farag S, Al-Mutairi A, Al-Shiltawy M. Comorbidities associated with psoriasis: An experience from the Middle East. J Dermatol. 2010;37:146–55. doi: 10.1111/J.1346-8138.2009.00777.X.

National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002 Dec 17;106(25):3143-421.

Bozek A, Reich A. The reliability of three psoriasis assessment tools: Psoriasis area and severity index, body surface area and physician global assessment. Adv Clin Experim Med. 2017;26. doi: 10.17219/acem/69804.

Pietrzak A, Chabros P, Grywalska E, Kiciński P, Franciszkiewicz-Pietrzak K, Krasowska D, et al. Serum lipid metabolism in psoriasis and psoriatic arthritis – an update. Arch Med Sci. 2018;15:369. doi: 10.5114/AOMS.2018.74021.

Alrubaye HK, Alhamdi KI, Abdel JAB, Alabbood MH. A study on lipid profile and apolipoprotein levels in psoriatic patients. Iranian J Dermatol. 2020;23. doi: 10.22034/ijd.2020.224160.1049.

Itani S, Arabi A, Harb D, Hamzeh D, Kibbi AG. High prevalence of metabolic syndrome in patients with psoriasis in Lebanon: a prospective study. Int J Dermatol. 2016 Apr;55(4):390-5. doi: 10.1111/ijd.12811.

Xiao Y, Jing D, Tang Z, Peng C, Yin M, Liu H, et al. Serum lipids and risk of incident psoriasis: a prospective cohort study from the UK Biobank Study and mendelian randomization analysis. J Inv Dermatol. 2022;142. doi: 10.1016/j.jid.2022.06.015.

Alogaily M, Alsaffar A, Hamid M. Prevalence of prediabetes among adults in Baghdad/Iraq. Iraqi J Med Sci 2019;17:215–22. doi: 10.22578/IJMS.17.3-4.8.

Mula-Abed WAS, Chilmeran SK. Prevalence of dyslipidemia in the Iraqi adult population. Saudi Med J 2007;28.

Al-Rawi HAG, Nori W, Salman DA, Issa AH, Akram W. The utility of maternal adiponectin and triglyceride-glycemic index for gestational diabetes mellitus screening: a cross-sectional study. Clin Exp Obstet Gynecol. 2024;51. doi: 10.31083/j.ceog5112262.

Piskin S, Gurkok F, Ekuklu G, Senol M. Serum lipid levels in psoriasis. Yonsei Med J. 2003;44. doi: 10.3349/ymj.2003.44.1.24.

Paine A, Brookes PS, Bhattacharya S, Li D, De La Luz Garcia-Hernandez M, Tausk F, et al. Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites. Arth Rheumatol. 2023;75. doi: 10.1002/art.42288.

Mirghani H, Altemani AT, Altemani ST, Alhatlani JAA, Alsulaimani NMI, AlHuraish DSA, et al. The cross talk between psoriasis, obesity, and dyslipidemia: a meta-analysis. Cureus 2023. doi: 10.7759/cureus.49253.

Setty AR, Curhan G, Choi HK. Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses’ health study II. Arch Intern Med 2007;167. doi: 10.1001/archinte.167.15.1670.

Fleming P, Kraft J, Gulliver WP, Lynde C. The relationship of obesity with the severity of psoriasis: A systematic review. J Cutan Med Surg 2015;19. doi: 10.1177/1203475415586332.

Bardazzi F, Balestri R, Baldi E, Antonucci A, De Tommaso S, Patrizi A. Correlation between BMI and PASI in patients affected by moderate to severe psoriasis undergoing biological therapy. Dermatol Ther 2010;23. doi: 10.1111/j.1529-8019.2009.01281.x.

Mohaseb AIA, Yasien HA, Ghanayem NA, El-Farargy SM. Correlation between psoriasis area severity index score and metabolic syndrome in psoriatic patients in Menoufia University. Menoufia Med J. 2021;34(3):23. doi: 10.4103/mmj.mmj_46_20.

Zhang X, Li X, Wang Y, Chen Y, Hu Y, Guo C, et al. Abnormal lipid metabolism in epidermal Langerhans cells mediates psoriasis-like dermatitis. JCI Insight 2022;7. doi: 10.1172/jci.insight.150223.

Sobhan M, Farshchian M. Associations between body mass index and severity of psoriasis. Clin Cosmet Investig Dermatol 2017;10. doi: 10.2147/CCID.S147236.

Wang X, Cheng Z. Cross-sectional studies: strengths, weaknesses, and recommendations. Chest 2020;158. doi: 10.1016/j.chest.2020.03.012.

Objavljeno
2025/06/30
Broj časopisa
Vol. 56 Br. 3 (2025): Maj-Jun
Rubrika
Originalni naučni članak
Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).