PERIODONTAL DISEASE RELATED TO OXIDATIVE STRESS

Ivan M Srejovic; Katerina Dirjanska; Beti Dejanova; Suncica Petrovska; Dragica Selakovic; Jovana Joksimovic; Kiro Ivanovski; Marija Nakova

doi:10.5937/sjecr14-3787

Ivan M Srejovic Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Republic of Serbia
Katerina Dirjanska Faculty of Dentistry, University of “Ss. Cirilius and Methodius” Skopje, Republic of Macedonia
Beti Dejanova Faculty of Medicine, University of “Ss. Cirilius and Methodius” Skopje, Republic of Macedonia
Suncica Petrovska Faculty of Medicine, University of “Ss. Cirilius and Methodius” Skopje, Republic of Macedonia
Dragica Selakovic Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Republic of Serbia
Jovana Joksimovic Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Republic of Serbia
Kiro Ivanovski Faculty of Dentistry, University of “Ss. Cirilius and Methodius” Skopje, Republic of Macedonia
Marija Nakova Faculty of Dentistry, University of “Ss. Cirilius and Methodius” Skopje, Republic of Macedonia

DOI: https://doi.org/10.5937/sjecr14-3787

Abstract

The study evaluates oxidative stress (OS) in patients with different stages of periodontal disease (PD), and the influence of their smoking habits. PD is related to connective tissue inflammation which leads to impairment of the tooth structure support. OS is a condition of free radicals (FR) overproduction which may be involved in PD, thus causes periodontal tissue damage and other related diseases. Patients’ groups were: I-non smokers (n=45), II-smokers (n=45), concerning 3 stages: mild (1), moderate (2) and severe (3) and control group (n=30). FR was determined by D-Roms test, total antioxidant capacity (AOC) by OXY-adsorbent test, (Diacron, Italy) and lipid peroxidation (LP) was determined by fluorimetric method with thiobarbituric acid method and its end product malonyldyaldehyde (MDA). OS was found in the periodontal tissue and serum of PD patients: FR showed the highest level in the severe stage (3) in non smokers (p<0.05) and in smokers (p<0.01); AOC showed decreasing values from mild (1) to severe stage (3) of PD for smokers (p<0.05). LP in serum showed the highest level in severe stage (3) in both groups, non smokers and smokers (p<0.05).

Due to obtained results, we may conclude that PD is related to OS, and may be either a cause or a trigger mechanism for more accelerated OS. Cigarette smoking increased FR production, and is a serious factor for further tissue damage in PD. These findings may contribute for possible use of efficient antioxidant agents as a prevention for PD and as a therapy for the disease better outcome.

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