USEFULNESS OF BASE DEFICIT IN AN ASSESSMENT OF SERUM LACTATE LEVELS IN CRITICALLY ILL PATIENTS ON MECHANICAL VENTILATION

Miloš N Novović; Filip Žunić; Marija Janković; Jasna Jevđić

doi:10.5937/sjecr14-4708

Miloš N Novović General Hospital Prijepolje, Department of anesthesiology and resuscitation
Filip Žunić Center for anesthesia and resuscitation, Clinical center Kragujevac
Marija Janković Dom zdravlja Zemun, služba za zdravstvenu zaštitu odraslih
Jasna Jevđić Center for anesthesia and resuscitation, Clinical center Kragujevac

DOI: https://doi.org/10.5937/sjecr14-4708

Keywords: Acidosis, Base deficit, Critical Illness, Lactates,

Abstract

Background/aim: Acid-base disturbances are common in critically ill patients. Some of the most used markers of metabolic acidosis are base deficit and lactate. The aim of this study was to evaluate correlation between base deficit and serum lactate and utility of base deficit in assessment of serum lactate levels in critical ill patients on mechanical ventilation.

Methods: This study was designed as a retrospective, analytical type of study. We reviewed all arterial gas analyses of patients on mechanical ventilation, which were measured base deficit and lactate levels. The correlation between base deficit and lactate was assessed by calculation of the Pearson correlation coefficient (r) and coefficient of determination (R²). Receiver operating characteristic (ROC) curves have been created for BD to detect the presence of hyperlactatemia. SPSS 12.0 software package (Chicago, Illinois) has been used for statistical analysis.

Results: 142 patients, survivors (n=68) and nonsurvivors (n=74). The mean value of base deficit was 0.512 ± 6.10 mmol/L and the mean value of serum lactate was 2.04 ± 2.07 mmol/L. There was no difference between the groups by lactate and base deficit values (p=0.101, p=0.106 respectively). Hyperlactatemia was observed in 44 patients (30.98 %). In ROC Curves Analysis, area under the curve for base deficit to detect hyperlactatemia was 0.527.

Conclusion: This study indicates that the base deficit is not appropriate marker in evaluation of real serum lactate values.

Author Biographies

Miloš N Novović, General Hospital Prijepolje, Department of anesthesiology and resuscitation

resident of anesthesiology, reanimatology and intensive therapy

Jasna Jevđić, Center for anesthesia and resuscitation, Clinical center Kragujevac

Professor of of anesthesiology, Faculty of medical sciences, University of Kragujevac

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