ANTI – GBM RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS (SYNDROMA GOODPASTURE) – CASE REPORT
Abstract
ABSTRACT
Introduction. Goodpasture's syndrome is a severe illness caused by the formation of antibodies to the glomerular basement membrane and alveolus with consequential damages of renal and pulmonary function. With current therapy, long term survival is greater than 50%, and before it the mortality due to this disease was higher than 90%. Case report. In our patient, disease has began as dysuria, then continued as anemic syndrome, and at the end the end stage renal failure developed. Immunosuppressive therapy with pulse doses Methylprednisolone and Cyclophosphamide, has introduced this patient in the disease remission, but the permanent impairment of renal function still remained. Conclusion. Early diagnosis of Goodpasture's syndrom allows to preserve renal function and has a positive effect on the survival of patients. In patients who achieve remission of the disease, a kidney transplant can be considered. According to this, our patient is in processing for transplantation.
Key words: Syndroma Goodpasture; collagen α3 (IV) chain; anti-GBM antibodies; crescentic forms.
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