NON-MEDICAL PRESCRIPTION DRUG USE IN SERBIA: RESULTS FROM THE NATIONAL SURVEY ON LIFESTYLES – SUBSTANCE ABUSE AND GAMBLING

  • Zorica Terzić Šupić Prof. Dr
  • Jovana Todorović University of Belgrade, Medical Faculty, Institute of Social Medicine
  • Biljana Kilibarda Institute of Public Health of Serbia ‘Dr Milan Jovanovic Batut’, Belgrade, Serbia
  • Viktor Mravčik National Monitoring Centre for Drugs and Addiction, Office of the Government, Prague, Czech Republic; Department of Addictology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Centre for Epidemiological and Clinical Research on Addictions, National Institute of Mental Health, Klecany, Czech Republic
Keywords: NMPDU, anti-anxiety medications, Serbia, factors

Abstract


Background: Non-medical prescription drug use (NMPDU) of anti-anxiety medications is a growing public health concern. The aim of this study was to examine the prevalence of the use of anti-anxiety medications, as well as the factors associated with the NMPDU of these medications among adults in Serbia. 

Materials and methods: The study is a secondary analysis of the data from the National Survey on Lifestyles in Serbia – Substance Abuse and Gambling, conducted in 2014 and 2018, with 7,385 participants. 

Results: The prevalence of prescription only use of anti-anxiety medications was 13.5% (995/7,385), while the prevalence of the non-medical prescription drug use was 5.04% (372/7,385). Multinomial logistic regression analysis showed an association between non-medical prescription use of anti-anxiety medications and the female sex (OR: 3.23), the age between 35 and 44 years (OR: 1.91), the age between 45 and 54 years (OR: 2.40), or the age between 55 and 64 years (OR: 2.97), reporting a low (OR: 2.40) or average (OR:1.67) satisfaction with health status, being a smoker (OR: 1.62), having moderate (OR: 2.35) or high (OR: 4.56) psychological distress, and having a low/moderate risk for pathological gambling (OR: 1.86). 

Conclusion: There is a clear need for the inclusion of health care professionals and media in the education of patients on the risks of self-medication, medication exchange, or illegal purchase of these medications. 

References

1. Cunliffe J, Décary-Hêtu D, Pollak TA. Nonmedical prescription psychiatric drug use and the darknet: A cryptomarket analysis. Int J Drug Policy. 2019;73:263-72. 

2. Substance Abuse and Mental Health Services Administration Center for Behavioral Health Statistics and Quality. RESULTS FROM THE 2016 NATIONAL SURVEY ON DRUG USE AND HEALTH: DETAILED TABLES. Rockville; 2017. 

3. Casati A, Sedefov R, Pfeiffer-Gerschel T. Misuse of medicines in the European union: A systematic review of the literature. Eur Addict Res. 2012;18(5):228-45. 

4. Gomez AF, Barthel AL, Hofmann SG. Comparing the Efficacy of Benzodiazepines and Serotonergic Anti-Depressants for Adults with Generalized Anxiety Disorder: A meta-analytic review. Expert Opin Pharmacother. 2018;19(8):883-94. 

5. Novak SP, Håkansson A, Martinez-Raga J, Reimer J, Krotki K, Varughese S. Nonmedical use of prescription drugs in the European Union. BMC Psychiatry. 2016;16(1):1-12. 

6. Mathews B, Yang C, Lehman EB, Mincemoyer C, Verdiglione N, Levi BH. Educating early childhood care and education providers to improve knowledge and attitudes about reporting child maltreatment : A randomized controlled trial. PlosOne. 2017;1-20. 

7. Ahrnsbrak R, Bose J, Hedden S, Lipari R, Park-Lee E. Key Substance Use and Mental Health Indicators in the United States: Results from the 2016 National Survey on Drug Use and Health. Subst Abus Ment Heal Serv Adm. 2017;7(1):877-726. 

8. Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health. HHS Publ No PEP19-5068, NSDUH Ser H-54. 2019;170:51-8. 

9. Wheeler P, Stevens-Watkins D, Knighton J. Pre-Incarceration Rates of Nonmedical Use of Prescription Drugs among Black Men from Urban Counties. 2018;95(4):444-53. 

10. Drazdowski TK. A systematic review of the motivations for the non-medical use of prescription drugs in young adults. Drug Alcohol Depend. 2016;162(2016):3-25. 

11. Nattala P, Murthy P, Thennarasu K, Cottler L. Nonmedical use of sedatives in urban Bengaluru. Indian J Psychiatry [Internet]. 2014;56(3):246. Dostupno: http://www.indianjpsychiatry.org/text.asp?2014/56/3/246/140619

12. Boyd CJ, McCabe SE. Coming to terms with the nonmedical use of prescription medications. Subst Abus Treat Prev Policy. 2008;3:1-3. 

13. Republic Institute of Public Health of Serbia “Dr Milan Jovanovic Batut.” National Health Survey 2013. 2014. 

14. Kilibarda Biljana NN. Istraživanje o stilovima života stanovništva Srbije 2018. godine. 2018. 

15. Kessler RC, Andrews G, Colpe LJ, Hiripi E, Mroczek DK, Normand SLT, et al. Short screening scales to monitor population prevalences and trends in non-specific psychological distress. Psychol Med [Internet]. 2002;32(6):959-76. Dostupno: http://www.ncbi.nlm.nih.gov/pubmed/12214795 

16. Currie SR, Hodgins DC, Casey DM. Validity of the Problem Gambling Severity Index Interpretive Categories. J Gambl Stud. 2013;29(2):311-27. 

17. Pakovic L, Todorovic J, Santric-Milicevic M, Bukumiric D, Terzic-Supic Z. The association between social characteristics, alcoholic beverage preferences, and binge drinking in a Serbian adult population. Nord Stud Alcohol Drugs [Internet]. 2018;145507251880328. Dostupno: http://journals.sagepub.com/doi/10.1177/1455072518803281

18. Schmitz A. Benzodiazepine use, misuse, and abuse: A review. Ment Heal Clin. 2016;6(3):120-6. 

19. Abrahamsson T, Hakansson A. Nonmedical Prescription Drug Use (NMPDU) in the Swedish General Population – Correlates of Analgesic and Sedative Use. Subst Use Misuse [Internet]. 2015;50(2):148-55. Dostupno:  http://www.tandfonline.com/doi/full/10.3109/10826084.2014.962047

20. Boyd CJ, West B, McCabe SE. Does misuse lead to a disorder? The misuse of prescription tranquilizer and sedative medications and subsequent substance use disorders in a U.S. longitudinal sample. Addict Behav. 2018;79(November 2017):17-23. 

21. Norbutas L. Offline constraints in online drug marketplaces: An exploratory analysis of a cryptomarket trade network. Int J Drug Policy. 2018;56(March):92-100. 

22. National Institute on Drug Abuse. Misuse of Prescription Drugs. 2018. p. 1-39. 

23. Chen LY, Chen YL, Tsay WI, Wu SC, Chen YT, Hsiao PC, et al. Nonmedical prescription drug use of analgesics and sedatives/hypnotics in Taiwan: Results from the 2014 National Survey of Substance Use. Prev Med Reports. 2019;15(March):100900. 

24. Knight KR. Women on the Edge: Opioids, Benzodiazepines, and the Social Anxieties Surrounding Women’s Reproduction in the U.S. “Opioid Epidemic.” Contemp Drug Probl. 2017;44(4):301-20. 

25. Cutler KA. Beauty and Care Versus Fun and Flair: Applying a Gendered Theory of Offending to College Students’ NMPDU. Deviant Behav. 2016;37(10):1132-51. 

26. Perreault M, Touré EH, Perreault N, Caron J. Employment Status and Mental Health: Mediating Roles of Social Support and Coping Strategies. Psychiatr Q. 2017;88(3):501-14. 

27. Clements AD, Cyphers NA. Prenatal substance use: Religious women report lower use rates, but do they use less? J Prev Interv Community. 2020;48(1):47-63. 

28. Grant JE, Lust K, Christenson GA, Redden SA, Chamberlain SR. Gambling and its clinical correlates in university students. Int J Psychiatry Clin Pract. 2019;23(1):33-9. 

29. Sundqvist K, Rosendahl I. Problem Gambling and Psychiatric Comorbidity-Risk and Temporal Sequencing Among Women and Men: Results from the Swelogs Case-Control Study. J Gambl Stud. 2019;35(3):757-71. 

Published
2023/09/27
Section
Original articles