NEONATAL BILATERAL HYPHEMA: A RARE PRESENTATION AND CLINICAL IMPLICATIONS

NEONATAL BILATERAL HYPHEMA

  • Dolika D. Vasović University Clinical Centre of Serbia
  • Jelica Pantelić Eye Hospital University Clinical Centre of Serbia
  • Dejan M. Rašić Eye Hospital University Clinical Centre of Serbia
Keywords: neonatal hyphema, intraocular hemorrhage, birth trauma, congenital infections, neonatal hematologic disorders

Abstract


Introduction: Neonatal hyphema, defined as intraocular bleeding into the anterior chamber, is a rare condition that requires immediate ophthalmologic evaluation. Unlike traumatic hyphema commonly seen in older children and adults, neonatal hyphema is typically associated with non-traumatic etiologies such as birth-related mechanical stress, hematologic disorders, congenital infections, or vascular anomalies. Bilateral involvement is particularly uncommon and necessitates a comprehensive systemic and ophthalmologic workup to rule out serious underlying pathology.

Case report: A female neonate was delivered at term via spontaneous vaginal delivery with normal Apgar scores and without perinatal complications. Shortly after birth, blood was observed in the anterior chambers of both eyes, more prominently in the right eye. Ophthalmologic examination confirmed bilateral hyphema with preserved corneal clarity. Systemic evaluation including complete blood count, coagulation studies, and TORCH serology ruled out coagulopathies and congenital infections. The patient was treated conservatively with topical atropine and corticosteroids. During hospitalization, the hyphema gradually resolved without evidence of elevated intraocular pressure or synechiae formation. The newborn was discharged with scheduled ophthalmologic follow-up to monitor for potential late complications.

Conclusion: This case underscores the importance of early recognition and multidisciplinary management of neonatal hyphema, particularly when both eyes are affected. Although birth trauma remains a common cause, thorough diagnostic evaluation is essential to exclude hematologic and infectious etiologies. Given the rarity of bilateral neonatal hyphema, additional case reports and studies are needed to enhance understanding of its etiology, optimal management, and long-term outcomes.

References

Yanoff M, Duker JS. Ophthalmology. 5th ed. Paris: Elsevier Masson; 2018.

Schwiesow KA, Diamond GR. Hyphema and elevated intraocular pressure in a neonate. J Pediatr Ophthalmol Strabismus. 2004 May-Jun;41(3):183-4. doi: 10.3928/0191-3913-20040501-14.

Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK. Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review. J Perinatol. 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30.

Ardell S, Offringa M, Ovelman C, Soll R. Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates. Cochrane Database Syst Rev. 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2.

Mets MB, Chhabra MS. Eye manifestations of intrauterine infections and their impact on childhood blindness. Surv Ophthalmol. 2008 Mar-Apr;53(2):95-111. doi: 10.1016/j.survophthal.2007.12.003.

Dasgupta S, Shakeel T, Roy RC. ToRCH-screening in pediatric cataract revisited: A North Indian tertiary care centre study. Indian J Ophthalmol. 2020 May;68(5):769-75. doi: 10.4103/ijo.IJO_1141_19.

Prakhunhungsit S, Berrocal AM. Diagnostic and Management Strategies in Patients with Persistent Fetal Vasculature: Current Insights. Clin Ophthalmol. 2020 Dec 10;14:4325-35. doi: 10.2147/OPTH.S236117.

Cassoux N, Lumbroso L, Levy-Gabriel C, Aerts I, Doz F, Desjardins L. Retinoblastoma: Update on Current Management. Asia Pac J Ophthalmol (Phila). 2017 May-Jun;6(3):290-5. doi: 10.22608/APO.201778.

Walton W, Von Hagen S, Grigorian R, Zarbin M. Management of traumatic hyphema. Surv Ophthalmol. 2002 Jul-Aug;47(4):297-334. doi: 10.1016/s0039-6257(02)00317-x.

Kiziltoprak H, Atesoglu Hİ, Tekin K, Yetkin E, Koc M. Evaluation of Densitometric Analysis for Early Detection of Corneal Blood Staining in Hyphema. Cornea. 2021 Apr;40(4):467-71. doi: 10.1097/ICO.0000000000002451.

Türkoğlu EB, Celik T, Celik E, Ozkan N, Bursalı O, Coşkun SB, Alagoz G. Is topical corticosteroid necessary in traumatic hyphema? J Fr Ophtalmol. 2014 Oct;37(8):613-7. doi: 10.1016/j.jfo.2014.04.007.

Puodžiuvienė E, Jokūbauskienė G, Vieversytė M, Asselineau K. A five-year retrospective study of the epidemiological characteristics and visual outcomes of pediatric ocular trauma. BMC Ophthalmol. 2018 Jan 18;18(1):10. doi: 10.1186/s12886-018-0676-7.

Published
2025/12/29
Section
Case reviews