USE OF NEGATIVE PRESSURE IN WOUND THERAPY

Keywords: wound, infection, healing, negative pressure therapy, open abdominal cavity

Abstract


The use of negative pressure in wound therapy is an innovative therapeutic method that accelerates the wound healing process. This technique is applied to various types of acute and chronic wounds and can shorten their healing time and improve the quality of the scars. Negative pressure therapy acts on the wound by improving blood circulation, reducing swelling, promoting the growth of granulation tissue, reducing the risk of infection, and improving the quality of scar formation. At the molecular level, negative pressure increases the expression of cytokines and growth factors that promote angiogenesis, extracellular matrix remodeling, and tissue regeneration.

Negative pressure therapy, as one of the techniques for temporary abdominal closing, is used in situations where the abdominal cavity must remain open for some time, in complex injuries, infections, and where there is a risk of compartment syndrome. In recent years, endoscopic vacuum therapy, a minimally invasive modality of treatment in colorectal surgery and surgery of the upper gastrointestinal tract, has emerged.

The possibilities of this therapy have not been completely exhausted. In addition to its multiple applications, it has been shown that negative pressure therapy reduces treatment costs, shortens the duration of hospital stay, and enables faster patient recovery.

Author Biographies

Slobodan Todorovic, University Hospital Medical Center Bezanijska Kosa, Medical Faculty in Belgrade

Head of the hepato-bilio-pancreatic surgery devision

Borislav Tošković, University Hospital Medical Center Bezanijska Kosa, Medical Faculty in Belgrade

Department of General and Abdominal Surgery

Jasna Gačić, University Hospital Medical Center Bezanijska Kosa, Medical Faculty in Belgrade

Department of Surgical Emergency

Nataša Čolaković, University Hospital Medical Center Bezanijska Kosa, Medical Faculty in Belgrade

Department of Surgical Oncology

Jelena Kostić, University Hospital Medical Center Bezanijska Kosa

Department of General and Abdominal Surgery

Stefan Guslarević, University Hospital Medical Center Bezanijska Kosa

Department of General and Abdominal Surgery

Igor Nadj, University Hospital Medical Center Bezanijska Kosa

Department of General and Abdominal Surgery

Jovana Mrda, University Hospital Medical Center Bezanijska Kosa

Department of General and Abdominal Surgery

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Published
2023/09/27
Section
Reviews