FAKTORI POVEZANI SA SUBJEKTIVNIM OSEĆAJEM UMORA TRI MESECA NAKON PRELEŽANE KOVID-19 INFEKCIJE

  • Dejan Mihajlović Univerzitet u Pristini sa privremenim sedistem u Kosovskoj Mitrovici, Medicinski fakultet, opsta medicina
  • Mirjana Virijević
  • Ana Radovanović
Ključne reči: umor, KOVID-19, post-KOVID-19, samoprocena

Sažetak


Uvod: Subjektivni osećaj umora je jedna od najčešćih post-KOVID-19 manifestacija. Karakteriše ga netolerancija na fizički i kognitivni napor, koji je pojedinac prethodno dobro podnosio, praćena malaksalošću i drugim simptomima.

Cilj: Cilj rada je bio da se ispita učestalost subjektivnog osećaja umora, tri meseca nakon izlečenja, kod pacijenata koji su preležali KOVID-19 infekciju, kao i da se ispitaju povezani faktori.

Metode: Studijom preseka obuhvaćeno je 110 pacijenata koji su preležali KOVID-19 infekciju, a koji su se javili na redovni kontrolni pregled u Zdravstveni centar „Kosovska Mitrovica“, tri meseca nakon izlečenja od akutne infekcije. Korišćen je specijalno konstruisani upitnik, koji se sastojao od dela sa sociodemografskim podacima, dela sa podacima o zdravstvenom stanju i KOVID-19 infekciji kod pacijenta, kao i dela upitnika o samoproceni zdravstvenog stanja nakon KOVID-19 infekcije.

Rezultati: U našem uzorku, od 110 ispitanika, čak 52 su osećala umor. Faktori koji su bili statistički značajno povezani sa subjektivnim osećajem umora, tri meseca nakon izlečenja od KOVID-19 infekcije, su starost ispitanika i hronične bolesti (p < 0,05). Prisustvo povišene telesne temperature i pneumonije tokom bolovanja od KOVID-19 infekcije bili su statistički značajno povezani sa subjektivnim osećajem umora, tri meseca nakon izlečenja (p < 0,05). Hospitalizovani pacijenti i oni koji su bili duže hospitalizovani su takođe češće osećali umor tri meseca nakon izlečenja (p < 0,05).

Zaključak: Subjektivni osećaj umora, tri meseca nakon izlečenja, kao jedna od post-KOVID-19 manifestacija, kao i sledstvena nemogućnost pacijenta da se vrati poslovnim i privatnim obavezama, može predstavljati ozbiljan lični i javnozdravstveni problem, zbog čega je potrebno njegovo adekvatno prepoznavanje i tretiranje.

Reference


  1. Ahn DG, Shin HJ, Kim MH, Lee S, Kim HS, Myoung J, Kim BT, Kim SJ. Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). J Microbiol Biotechnol. 2020 Mar 28;30(3):313-324.

  2. Atzrodt CL, Maknojia I, McCarthy RDP, Oldfield TM, Po J, Ta KTL, Stepp HE, Clements TP. A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2. FEBS J. 2020 Sep;287(17):3633-3650. 

  3. Gao Z, Xu Y, Sun C, et al. A systematic review of asymptomatic infections with COVID-19. J Microbiol Immunol Infect. 2021;54(1):12-16.

  4. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 Aug 25;324(8):782-793.

  5. Attaway A H, Scheraga R G, Bhimraj A, Biehl M, HatipoÄŸlu U. Severe covid-19 pneumonia: pathogenesis and clinical management BMJ 2021; 372 :n436

  6. Lamprecht B. Gibt es ein Post-COVID-Syndrom? [Is there a post-COVID syndrome?]. Pneumologe (Berl). 2020 Oct 8:1-4. German.

  7. Maltezou HC, Pavli A, Tsakris A. Post-COVID Syndrome: An Insight on Its Pathogenesis. Vaccines (Basel). 2021 May 12;9(5):497. doi: 10.3390/vaccines9050497. PMID: 34066007; PMCID: PMC8151752.

  8. Nacul, Luis et al. “European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe.” Medicina (Kaunas, Lithuania) vol. 57,5 510. 19 May. 202

  9. Roerink ME, van der Schaaf ME, Dinarello CA, Knoop H, van der Meer JW. Interleukin-1 as a mediator of fatigue in disease: a narrative review. J Neuroinflammation. 2017;14(1):16. Published 2017 Jan 21. doi:10.1186/s12974-017-0796-7

  10. Russell A, Hepgul N, Nikkheslat N, et al. Persistent fatigue induced by interferon-alpha: a novel, inflammation-based, proxy model of chronic fatigue syndrome. Psychoneuroendocrinology. 2019;100:276-285. doi:10.1016/j.psyneuen.2018.11.032

  11. "CDC, Chronic Fatigue Syndrome (CFS), Making a Diagnosis" (PDF). Cdc.gov. Archived (PDF) from the original on 2011-10-16.

  12. Ross SD, Estok RP, Frame D, Stone LR, Ludensky V, Levine CB (May 2004). "Disability and chronic fatigue syndrome: a focus on function". Archives of Internal Medicine. 164 (10): 1098–107.

  13. Mackay A. A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS. Front Neurol. 2021 Aug 2;12:701419. doi: 10.3389/fneur.2021.701419. PMID: 34408721;

  14. Tenforde MW, Kim SS, Lindsell CJ, Rose EB, Shapiro NI, Files DC, et al. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network — united states, march–june 2020) MMWR. (2020) 69:993–8

  15. Carfì A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA. (2020) 324:603–5.

  16. Townsend L, Dyer AH, Jones K, Dunne J, Mooney A, Gaffney F, et al. Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. PLoS ONE. (2020) 15:e0240784

  17. Huang C, Huang L, Wang Y, Li X, Ren L et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021 Jan 16;397(10270):220-232.

  18. Tenforde, Mark W et al. “Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020.” MMWR. Morbidity and mortality weekly report vol. 69,30 993-998. 31 Jul. 2020, doi:10.15585/mmwr.mm6930e1

  19. Carvalho-Schneider C, Laurent E, Lemaignen A. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin Microbiol Infect. 2020

  20. Stavem K, Ghanima W, Olsen MK, Gilboe HM, Einvik G. Prevalence and determinants of fatigue after COVID-19 in non-hospitalized subjects: a population-based study. 2021.

  21. Iqbal FM, Lam K, Sounderajah V, Clarke JM, Ashrafian H, Darzi A. Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis. EClinicalMedicine. 2021;36:100899.

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2022/03/24
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