INTRAOPERATIVNI ULTRAZVUK U LOKALIZOVANJU NEPALPABILNIH LEZIJA DOJKE

  • Katarina Zečić Klinika za ginekologiju i akušerstvo, Univerzitetski klinički centar Srbije
  • Ognjen Zečić Kliničko-bolnički centar „Bežanijska Kosa”, Beograd, Srbija
Ključne reči: intraoperativni ultrazvuk, dojka, nepalpabilna lezija

Sažetak


Uvod: Intraoperativni ultrazvuk u hirurgiji tumora dojke je relativno novi pristup u lokalizovanju nepalpabilnih tumora. Brojne su prednosti ove tehnike u odnosu na mamografsku preoperativnu lokalizaciju žičanom iglom (wire needle localisation - WNL), koja predstavlja standardni pristup u lokalizovanju nepalpabilnih lezija dojke. Pokazalo se da operacije tumora dojke vođene ultrazvukom daju manji procenat pozitivnih ivica resekcije, uz manji volumen ekscidiranog zdravog tkiva dojke oko tumora.

Cilj: Cilj ovog rada je procena uspešnosti ekscizije nepalpabilnih lezija u dojci lokalizovanjem tih lezija intraoperativnim ultrazvukom.

Materijal i metode: Analiza je retrospektivna, obuhvata pacijente operisane na Odeljenju onkološke hirurgije KBC „Bežanijska kosa“ u periodu od januara 2013. do decembra 2017. godine. Inkluzioni kriterijum je nepalpabilna lezija kod koje je intraoperativni ultrazvuk bio jedino sredstvo lokalizovanja. Procena uspešnosti identifikovanja i ekscizije nepalpabilnih lezija izražena je u procentima (namera/uspešna realizacija). 

Rezultati: Od 2627 pacijentkinja operisanih u ovom periodu, 317 pacijentkinja (11,9%) je imalo nepalpabilne lezije, od kojih su 173 lokalizovane WNL, a 144 introperativnim ultrazvukom (IOUZ). Od 144 pacijentkinje kod kojih su lezije lokalizovane IOUZ, 61 je imalo karcinom dojke, a 83 benigne lezije. Na osnovu operativnih nalaza sve nepalpabilne lezije u dojkama su uspešno lokalizovane intraoperativnim ultrazvukom i ekscidirane (144/144 – 100%).

Zaključak: Intraoperativni ultrazvuk predstavlja optimalno sredstvo lokalizovanja ultrazvukom vidljivih nepalpabilnih lezija u dojci kod kojih je indikovana hirurška ekscizija.

Reference

Schwartz GF, Goldberg BB, Rifkin MD, D'Orazio SE. Ultrasonography: an alternative to x-ray-guided needle localization of nonpalpable breast masses. Surgery. 1988 Nov;104(5):870-3.

Rahusen FD, Taets van Amerongen AH, van Diest PJ, Borgstein PJ, Bleichrodt RP, Meijer S. Ultrasound-guided lumpectomy of nonpalpable breast cancers: A feasibility study looking at the accuracy of obtained margins. J Surg Oncol. 1999 Oct;72(2):72-6. doi: 10.1002/(sici)1096-9098(199910)72:2<72::aid-jso6>3.0.co;2-m.

Snider HC Jr, Morrison DG. Intraoperative ultrasound localization of nonpalpable breast lesions. Ann Surg Oncol. 1999 Apr-May;6(3):308-14. doi: 10.1007/s10434-999-0308-9.

Harlow SP, Krag DN, Ames SE, Weaver DL. Intraoperative ultrasound localization to guide surgical excision of nonpalpable breast carcinoma. J Am Coll Surg. 1999 Sep;189(3):241-6. doi: 10.1016/s1072-7515(99)00156-8.

Smith LF, Rubio IT, Henry-Tillman R, Korourian S, Klimberg VS. Intraoperative ultrasound-guided breast biopsy. Am J Surg. 2000 Dec;180(6):419-23. doi: 10.1016/s0002-9610(00)00500-6.

Rahusen FD, Bremers AJ, Fabry HF, van Amerongen AH, Boom RP, Meijer S. Ultrasound-guided lumpectomy of nonpalpable breast cancer versus wire-guided resection: a randomized clinical trial. Ann Surg Oncol. 2002 Dec;9(10):994-8. doi: 10.1007/BF02574518.

Kaufman CS, Jacobson L, Bachman B, Kaufman LB. Intraoperative ultrasonography guidance is accurate and efficient according to results in 100 breast cancer patients. Am J Surg. 2003 Oct;186(4):378-82. doi: 10.1016/s0002-9610(03)00278-2.

Bennett IC, Greenslade J, Chiam H. Intraoperative ultrasound-guided excision of nonpalpable breast lesions. World J Surg. 2005 Mar;29(3):369-74. doi: 10.1007/s00268-004-7554-6.

Haid A, Knauer M, Dunzinger S, Jasarevic Z, Köberle-Wührer R, Schuster A, et al. Intra-operative sonography: a valuable aid during breast-conserving surgery for occult breast cancer. Ann Surg Oncol. 2007 Nov;14(11):3090-101. doi: 10.1245/s10434-007-9490-9.

Potter S, Govindarajulu S, Cawthorn SJ, Sahu AK. Accuracy of sonographic localisation and specimen ultrasound performed by surgeons in impalpable screen-detected breast lesions. Breast. 2007 Aug;16(4):425-8. doi: 10.1016/j.breast.2007.02.001.

Ngô C, Pollet AG, Laperrelle J, Ackerman G, Gomme S, Thibault F, et al. Intraoperative ultrasound localization of nonpalpable breast cancers. Ann Surg Oncol. 2007 Sep;14(9):2485-9. doi: 10.1245/s10434-007-9420-x.

Fortunato L, Penteriani R, Farina M, Vitelli CE, Piro FR. Intraoperative ultrasound is an effective and preferable technique to localize non-palpable breast tumors. Eur J Surg Oncol. 2008 Dec;34(12):1289-92. doi: 10.1016/j.ejso.2007.11.011.

Barentsz MW, van Dalen T, Gobardhan PD, Bongers V, Perre CI, Pijnappel RM, et al. Intraoperative ultrasound guidance for excision of non-palpable invasive breast cancer: a hospital-based series and an overview of the literature. Breast Cancer Res Treat. 2012 Aug;135(1):209-19. doi: 10.1007/s10549-012-2165-7.

Yu CC, Chiang KC, Kuo WL, Shen SC, Lo YF, Chen SC. Low re-excision rate for positive margins in patients treated with ultrasound-guided breast-conserving surgery. Breast. 2013 Oct;22(5):698-702. doi: 10.1016/j.breast.2012.12.019.

Ramos M, Díaz JC, Ramos T, Ruano R, Aparicio M, Sancho M, et al. Ultrasound-guided excision combined with intraoperative assessment of gross macroscopic margins decreases the rate of reoperations for non-palpable invasive breast cancer. Breast. 2013 Aug;22(4):520-4. doi: 10.1016/j.breast.2012.10.006.

James TA, Harlow S, Sheehey-Jones J, Hart M, Gaspari C, Stanley M, et al. Intraoperative ultrasound versus mammographic needle localization for ductal carcinoma in situ. Ann Surg Oncol. 2009 May;16(5):1164-9. doi: 10.1245/s10434-009-0388-6.

Bouton ME, Wilhelmson KL, Komenaka IK. Intraoperative ultrasound can facilitate the wire guided breast procedure for mammographic abnormalities. Am Surg. 2011 May;77(5):640-6.

Moore MM, Whitney LA, Cerilli L, Imbrie JZ, Bunch M, Simpson VB, et al. Intraoperative ultrasound is associated with clear lumpectomy margins for palpable infiltrating ductal breast cancer. Ann Surg. 2001 Jun;233(6):761-8. doi: 10.1097/00000658-200106000-00005.

Olsha O, Shemesh D, Carmon M, Sibirsky O, Abu Dalo R, Rivkin L, et al. Resection margins in ultrasound-guided breast-conserving surgery. Ann Surg Oncol. 2011 Feb;18(2):447-52. doi: 10.1245/s10434-010-1280-0.

Davis KM, Hsu CH, Bouton ME, Wilhelmson KL, Komenaka IK. Intraoperative ultrasound can decrease the re-excision lumpectomy rate in patients with palpable breast cancers. Am Surg. 2011 Jun;77(6):720-5.

Fisher CS, Mushawah FA, Cyr AE, Gao F, Margenthaler JA. Ultrasound-guided lumpectomy for palpable breast cancers. Ann Surg Oncol. 2011 Oct;18(11):3198-203. doi: 10.1245/s10434-011-1958-y.

Krekel NM, Lopes Cardozo AM, Muller S, Bergers E, Meijer S, van den Tol MP. Optimising surgical accuracy in palpable breast cancer with intra-operative breast ultrasound--feasibility and surgeons' learning curve. Eur J Surg Oncol. 2011 Dec;37(12):1044-50. doi: 10.1016/j.ejso.2011.08.127.

Eichler C, Hübbel A, Zarghooni V, Thomas A, Gluz O, Stoff-Khalili M, et al. Intraoperative ultrasound: improved resection rates in breast-conserving surgery. Anticancer Res. 2012 Mar;32(3):1051-6.

Krekel NM, Haloua MH, Lopes Cardozo AM, de Wit RH, Bosch AM, de Widt-Levert LM, et al. Intraoperative ultrasound guidance for palpable breast cancer excision (COBALT trial): a multicentre, randomised controlled trial. Lancet Oncol. 2013 Jan;14(1):48-54. doi: 10.1016/S1470-2045(12)70527-2.

Ivanovic N. Vizuelizacija nepalpabilnih lezija u dojci tokom hirurškog rada. In: Andrejević T, editor. Intraoperativni ultrazvuk u hirurgiji tumora dojke. Beograd: Zadužbina Andrejević; 2013. p. 61-6.

Ivanovic NS, Zdravkovic DD, Skuric Z, Kostic J, Colakovic N, Stojiljkovic M, et al. Optimization of breast cancer excision by intraoperative ultrasound and marking needle - technique description and feasibility. World J Surg Oncol. 2015 Apr 18;13:153. doi: 10.1186/s12957-015-0568-8.

Objavljeno
2023/12/29
Rubrika
Serija slučajeva