FEROPTOZA I NJEN KLINIČKI ZNAČAJ

Danijela Agić; Marijana Vranješ; Marina  Dragičević Jojkić; Amir El Farra; Ivana Urošević

doi:10.5937/smclk5-52576

Danijela Agić
Marijana Vranješ Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Clinic for hematology
Marina Dragičević Jojkić
Amir El Farra Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Clinic for hematology
Ivana Urošević Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina, Clinic for hematology

DOI: https://doi.org/10.5937/smclk5-52576

Ključne reči: gvožđe, limfom, terapijski agensi, ćelijska smrt

Sažetak

Uvod: Feroptoza, koju su prvi put spomenuli Dikson i saradnici, 2012. godine, jeste put ćelijske smrti zavisan od gvožđa, uz neophodno prisustvo lipidnih peroksida. Mehanizam procesa i signalni putevi koji u njemu učestvuju se razlikuju u odnosu na ranije poznatu apoptozu, nekrozu i autofagiju. Dolazi i do zapaljenske reakcije, što ovaj put ćelijske smrti dodatno razlikuje od apoptotskog puta. Ferostatin dovodi do inhibicije ovog procesa.

Metode: Urađen je pregled literature dobijene pretraživanjem Medline baze podataka sa posebnim osvrtom na radove koji su se bavili značajem feroptoze u kliničkoj medicini, prvenstveno hematologiji.

Rezultati: Metabolizam gvožđa u malignoj i zdravoj ćeliji se razlikuje. Maligne ćelije dobro tolerišu oksidativni stres i izbegavaju feroptozu. Po literaturnim podacima, različiti ispitivani agensi stimulišu feroptozu i time postaju mogući terapijski agensi. Neki geni povezani sa metabolizmom gvožđa pokazali su prognostički značaj kod obolelih od difuznog B krupnoćelijskog limfoma.

Zaključak: Otkrivanje novih mehanizama ćelijske smrti i signalnih puteva koji su u taj proces uključeni dovodi do potencijalno nove ciljne terapije. Iako obećavaju, ovi rezultati zahtevaju validaciju kroz dalja istraživanja.

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