UTICAJ GEOMETRIJE LEVE KOMORE, ISKAZANE DEBLJINOM INTERVENTRIKULARNOG SEPTUMA I ZADNJEG ZIDA KOMORE, NA ISHOD AKUTNOG ISHEMIJSKOG MOŽDANOG UDARA
Sažetak
Uvod/Cilj: Značajni udeo zdravstvenog opterećenja stanovništva obuhvata akutni moždani udar. Varijable dobijene transtorakalnom ehokardiografijom predstavljaju jasne prediktore ishoda kardioloških oboljenja, ali je i sve više dokaza o njihovom značaju u predviđanju ishoda neuroangioloških oboljenja.
Cilj rada jeste da se dokaže hipoteza da je promena geometrije leve komore iskazana porastom dimenzije zidova leve komore primenljiv marker lošeg ishoda akutnog moždanog udara.
Materijali i metode: Metodologija je bazirana na analizi ultrazvučnih varijabli 167 pacijenata koji su pretrpeli akutni moždani udar ishemijske geneze, uz analizu varijabli modifikovanog Rankin skora definisanog pri otpustu sa lečenja, a kao pokazatelja ishoda bolesti u funkcionalnom smislu.
Rezultati: Rad ukazuje na korelacija između debljine kako interventrikularnog septuma tako i zadnjeg zida leve komore sa jedne i funkcionalnog stanja bolesnika, sa druge strane. Hipoteza se pokazala tačnom, odnosno porastom dijametra interventrikularnog septuma i/ili zadnjeg zida leve komore, raste i mogućnost lošijeg ishoda bolesti.
Zaključak: Oba praćena parametra pokazuju pozitivnu prediktivnu vrednost u odnosu na stepen funkcionalnosti pacijenata pri otpustu.
Reference
Feigin VL, Brainin M, Norrving B, Martins SO, Pandian J, Lindsay P, et al. World Stroke Organization: Global Stroke Fact Sheet 2025. Int J Stroke. 2025 Feb;20(2):132-44. doi: 10.1177/17474930241308142.
Pu L, Wang L, Zhang R, Zhao T, Jiang Y, Han L. Projected Global Trends in Ischemic Stroke Incidence, Deaths and Disability-Adjusted Life Years From 2020 to 2030. Stroke. 2023 May;54(5):1330-9. doi: 10.1161/STROKEAHA.122.040073. Erratum in: Stroke. 2024 Jan;55(1):e23. doi: 10.1161/STR.0000000000000452.
GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021 Oct;20(10):795-20. doi: 10.1016/S1474-4422(21)00252-0.
Soto A, Guillén-Grima F, Morales G, Muñoz S, Aguinaga-Ontoso I, Fuentes-Aspe R. [Prevalence and incidence of ictus in Europe: systematic review and meta-analysis]. An Sist Sanit Navar. 2022 Apr 28;45(1):e0979. Spanish. doi: 10.23938/ASSN.0979.
Imoisili OE, Chung A, Tong X, Hayes DK, Loustalot F. Prevalence of Stroke - Behavioral Risk Factor Surveillance System, United States, 2011-2022. MMWR Morb Mortal Wkly Rep. 2024 May 23;73(20):449-55. doi: 10.15585/mmwr.mm7320a1.
Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. doi: 10.1016/j.echo.2014.10.003.
Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, et al. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016 Apr;29(4):277-314. doi: 10.1016/j.echo.2016.01.011.
Ghali JK, Liao Y, Cooper RS. Influence of left ventricular geometric patterns on prognosis in patients with or without coronary artery disease. J Am Coll Cardiol. 1998 Jun;31(7):1635-40. doi: 10.1016/s0735-1097(98)00131-4.
Yamaguchi S, Shimabukuro M, Abe M, Arakaki T, Arasaki O, Ueda S. Comparison of the prognostic values of three calculation methods for echocardiographic relative wall thickness in acute decompensated heart failure. Cardiovasc Ultrasound. 2019 Dec 3;17(1):30. doi: 10.1186/s12947-019-0179-6.
Zhang Y, Qiao S, Hao H, Li Q, Bao X, Wang K, et al. The predictive value of relative wall thickness on the prognosis of the patients with ST-segment elevation myocardial infarction. BMC Cardiovasc Disord. 2023 Jul 31;23(1):383. doi: 10.1186/s12872-023-03379-5.
Sun D, Schaff HV, Nishimura RA, Geske JB, Dearani JA, Ducharme MT, et al. Posterior Wall Thickness Associates With Survival Following Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy. JACC Heart Fail. 2022 Nov;10(11):831-7. doi: 10.1016/j.jchf.2022.06.009.
Gardin JM. The Value of Left Ventricular Relative Wall Thickness in Predicting Ventricular Arrhythmia and Related Death. J Am Coll Cardiol. 2016 Jan 26;67(3):313-5. doi: 10.1016/j.jacc.2015.10.078.
Yang Y, Li Z, Guo X, Zhou Y, Chang Y, Yang H, et al. Interventricular Septum Thickness for the Prediction of Coronary Heart Disease and Myocardial Infarction in Hypertension Population: A Prospective Study. J Clin Med. 2022 Dec 1;11(23):7152. doi: 10.3390/jcm11237152.
Apostolakis S, Sullivan RM, Olshansky B, Lip GY. Left ventricular geometry and outcomes in patients with atrial fibrillation: the AFFIRM Trial. Int J Cardiol. 2014 Jan 1;170(3):303-8. doi: 10.1016/j.ijcard.2013.11.002.
Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990 May 31;322(22):1561-6. doi: 10.1056/NEJM199005313222203.
Adeoye AM, Ovbiagele B, Akinyemi JO, Ogah OS, Akinyemi R, Gebregziabher M, et al. Echocardiographic Abnormalities and Determinants of 1-Month Outcome of Stroke Among West Africans in the SIREN Study. J Am Heart Assoc. 2019 Jun 4;8(11):e010814. doi: 10.1161/JAHA.118.010814.
Park CS, Park JB, Kim Y, Yoon YE, Lee SP, Kim HK, et al. Left Ventricular Geometry Determines Prognosis and Reverse J-Shaped Relation Between Blood Pressure and Mortality in Ischemic Stroke Patients. JACC Cardiovasc Imaging. 2018 Mar;11(3):373-82. doi: 10.1016/j.jcmg.2017.02.015.
Tatar S, Kesriklioğlu S, Şalvarcı A, Yaşaroğlu MY, Tokgöz OS. The effect of aortic arch calcification on in-hospital mortality in patients with hemorrhagic stroke. Neurology Asia. 2025 Mar;30(1):19-25. doi: 10.54029/2025uyc.
