Malignant fibrous histiocytoma of the right upper leg – A case report

Mladen Pavlovic; Bojan Milošević; Dragče Radovanović; Aleksandar Cvetković; Bratislav Trifunović; Dragan Čanović; Slobodanka Mitrović; Milan Jovanović; Marko Spasić; Maja Vulović; Bojan Stojanović; Dejan Jeremić; Jasna Jevđić

doi:10.2298/VSP160512237P

Mladen Pavlovic KC Kragujevac Faculty of Medical Sciences, University of Kragujevac
Bojan Milošević KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Dragče Radovanović Klinika za opštu i grudnu hirurgiju, KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Aleksandar Cvetković Klinika za opštu i grudnu hirurgiju, KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Bratislav Trifunović Military Medical Academy, Clinic for General Surgery, Belgrade
Dragan Čanović Klinika za opštu i grudnu hirurgiju, KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Slobodanka Mitrović Centar za patologiju, KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Milan Jovanović Klinika za opštu hirurgiju, VMA
Marko Spasić Klinika za opštu i grudnu hirurgiju, KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Maja Vulović Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Bojan Stojanović Klinika za opštu i grudnu hirurgiju, KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Dejan Jeremić Fakultet medicinskih nauka, Univerzitet u Kragujevcu
Jasna Jevđić Centar za anesteziju i reanimaciju, KC Kragujevac Fakultet medicinskih nauka, Univerzitet u Kragujevcu

DOI: https://doi.org/10.2298/VSP160512237P

Keywords: sarcoma;, soft tissue neoplasms;, diagnosis;, histological techniques;, surgical procedures, operative

Abstract

Introduction. Malignant fibrous histiocytoma is a fast spreading pleomorphic sarcoma with a high malignant potential. Its spreading is characterized with local invasion and distant metastazes with early onset. Most common localisations of development are extremities, trunk and retroperitoneum. Given the line of rare case and specimen, lack of a clear etiology and mechanisms of this disease, as well as adequate histopathologic findings and intraoperative documentation, we presented current status, discuss putative etiology, histopathology with variant morphology, differential diagnosis and treatment modalities. Case report. We presented a 56-years-old female Serbian with tumor in the thigh that clinically resembles incapsulated hematoma. Computed tomography revealed intramuscular tumor with a heterodense structure and compression on surround tissue. Ex tempore biopsy specimen showed malignant potential of the tumor. Wide and radical excision of the nodule has been done, and definitive histopathological verification revealed malignant fibrous histiocytoma. Conclusion. Malignant fibrous histiocytoma is a most common type of soft tissue sarcomas in adults. Frequent localization is on lower extremities, and every rapidly enlarging nodule in this localization that on computed tomography is like incapsulated hematoma with necrotic zone should alert suspicion on presence of this type of sarcoma

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