Prisustvo bakterije Tannerella forsythia kod bolesnika sa hroničnom periodontalnom bolešću i arterosklerozom

  • Danijela Staletović University of Priština Kosovska Mitrovica, Faculty of Medicine, Clinic for Dentistry, Kosovska Mitrovica, Serbia
  • Ibrachim Kannosh University of Belgrade, Faculty of Dental Medicine, Department of Human Genetics, Belgrade, Serbia
  • Meliha Šehalić University of Priština Kosovska Mitrovica, Faculty of Medicine, Clinic for Dentistry, Kosovska Mitrovica, Serbia
  • Vladanka Vukićević University of Priština Kosovska Mitrovica, Faculty of Medicine, Clinic for Dentistry, Kosovska Mitrovica, Serbia
  • Zoraida Milojković University of Priština Kosovska Mitrovica, Faculty of Medicine, Clinic for Dentistry, Kosovska Mitrovica, Serbia
  • Aleksandra Ilić University of Priština Kosovska Mitrovica, Faculty of Medicine, Institute for Preventive Medicine, Kosovska Mitrovica, Serbia
  • Verica Pavlić Institute for Dentistry, Banja Luka, Bosnia and Herzegovina
  • Zlata Brkić University of Defence, Faculty of Medicine of the Military Medical Academy, Belgarde Serbia
DOI: https://doi.org/10.2298/VSP180321121S
Ključne reči: periodontitis, periapikalni, tannerella forsythia, ateroskleroza, faktori rizika, komorbiditet

Sažetak


Uvod/Cilj. Parodontopatija je zapaljensko oboljenje pot­pornog aparata zuba, koje se javlja kao odgovor na pri­sus­tvo dentalnog plaka. Između ostalih, Tannerella forsythia (Tf) je jedna od značajnih i veoma specifičnih bakterija koja se nalazi u periodontalnom džepu i pripada bakterijama „crve­nog kompleksa“. Ateroskleroza je progresivno sužavanje arterija koje može, konačno, dovesti do njihovog potpunog začepljenja, kao rezultat nakupljanja masti. Smatra se vo­dećim uzrokom koronarne srčane bolesti (80%), kao i infarkta miokarda i moždanog udara. Sve više je objavljenih radova na temu potencijalne povezanosti parodontopatija i kardiovaskulranih oboljenja, gde se smatra da bakterije prisutne u periodontalnom džepu, između ostalih Tf, mogu prodreti u sistemsku cirkulaciju direktnim ili indirektnim putem. Cilj ove studije bio je utvrđivanje prisutnosti Tf u aterosklerotskim plakovima različitih krvnih sudova osoba obolelih od hronične parodontopatije. Metode. U ovu stu­diju je bilo uključeno 90 pacijenata (61 muškarac i 29 žena) sa dijagnozom parodontopatije i ateroskleroze koji su bili podvrgnuti endarterektomiji ili perkutanoj transluminalnoj koronarnoj angioplastici. Klinički pregled za parodonto­pa­tiju sastojao se od utvrđivanja plak indeksa (po Silness Lӧu), gingivalnog indeksa (po Lӧe Silnes), indeksa krvarenja iz sulkusa (po Mühleman-Son) i dubine periodontalnog džepa. Prisustvo Tf u periodontalnom džepu i aterosklerozom izmenjenim krvnim sudovima detektovano je metodom lančane reakcije polimeraze [polymerase chain reaction (PCR)] uz Tf ATCC 43037 kao pozitivne kontrole. Rezultati. Tf je bila prisutna u subgingivalnom plaku kod 68 (76%) paci­jenata, dok je njeno prisustvo u aterosklerotskim plakovima zabeleženo kod njih 42 (53,3%). Značajno prisustvo Tf je zabeleženo u koronarnim arterijama (41,7%), karotidnim arterijama (35,4%), zatim u aneurizmama a. abdominalis (12,5%), a. mamaria (8,5%) i a. femoralis (2,1%), dok u a. iliaca Tf nije bila prisutna. Zaključak. Ovom studijom utvrđena je jaka povezanost parodontopatije i aterogeneze, te se smatra da bi se parodontopatija trebala uvrstiti u potencijalne fak­to­re rizika od nastanka ateroskleroze. Takođe, bilo bi neop­hod­no da se kontroliše parodontopatija kako bi se smanjio rizik od oboljevanja i smrtnosti povezanih sa aterosklerozom.

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Objavljeno
2021/04/19
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Vol. 77 Br. 6 (2020): Vojnosanit pregl
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