Osnovne karakteristike pacijenata akutno otrovanih etanolom na području Beograda (Srbija)

  • Zoran Šegrt Department for Treatment, Military Medical Academy, Belgrade, Serbia;Medical Faculty, Military Medical Academy, Belgrade, Serbia
  • Slavica Vučinić National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical Faculty, Military Medical Academy, Belgrade, Serbia
  • Nemanja Rančić Center for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia; Medical faculty, Military Medical Academy, Belgrade, Serbia
  • Nataša Vukčević-Perković National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical Faculty, Military Medical Academy, Belgrade, Serbia
  • Gordana Vuković-Ercegović National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical Faculty, Military Medical Academy, Belgrade, Serbia
  • Olivera Potrebić National Poison Control Centre, Military Medical Academy, Belgrade, Serbia
  • Aleksandra Kovačević Center for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia; Medical faculty, Military Medical Academy, Belgrade, Serbia
  • Vesna Mijatović Jovin Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi, Serbia
  • Vesna Jaćević National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical faculty, Military Medical Academy, Belgrade, Serbia;Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic
Ključne reči: etanol;, trovanje alkoholom;, srbija;, demografija;, faktori rizika

Sažetak


Uvod/Cilj. Akutno trovanje etanolom čini značajan deo akutne patologije izazvane toksičnim hemikalijama, a koja zahtevaju medicinsko zbrinjavanje u specijalizovanim zdrav­stvenim ustanovama. Cilj studije bio je da se utvrde osnovne karakteristike pacijenata lečenih zbog akutnog trovanja eta­nolom, kao što su: prosečna starost, pol, stepen težine tro­vanja, smrtnost, učešće u ukupnom broju pacijenata zbrinu­tih zbog akutnog trovanja hemijskim agensima i odnos ambulantno i bolnički zbrinutih bolesnika. Metode. Peto­gdišnja retrospektivna studija slučaja je obuhvatila 20891 akutno otrovanog pacijenta u periodu 2011–2015. godina, od čega je 10731 zrinut zbog akutnog trovanja etanolom. Svi pacijenti zadovoljavali su dijagnostičke kriterijume tro­vanja prema Međunarodnoj klasifikaciji bolesti, 10 revizija, propisanoj od strane Svetske zdravstvene organizacije i Standardizovanoj skali težine trovanja. Rezultati. Praćeni parametri analizirani su kod 10731 pacijenta akutno otro­vanog etanolom, a njihov prosečan broj u toku jedne studijske godine iznosio je 2146,2 ± 437,95. Prosečan broj zbrinutih pacijenata zbog akutnog trovanja etanolom (51,47 ± 2,86%) bio je statistički značajno veći od prosečnog broja zbrinutih zbog akutnih trovanja uzrokovanih drugim agen­sima (p < 0,001). Većina otrovnih pacijenata bile su osobe muškog pola, životne dobi od 19 do 40 godina i 41 do 65 godina, sa blagim do umerenim simptomima akutne into­ksikacije etanolom, pri čemu je najviše pacijenata akutno otrovanih etanolom imalo skor težine trovanja 1 (70,25 ± 5,04%, p < 0,001). Veoma mali broj akutno otrovanih eta­nolom zahtevao je hospitalno lečenje (1,05%). Pretpo­stavljeni broj pacijenata sa akutnim trovanjem etanolom imao je visok procenat povećanja za razdoblje od 2016. do 2020. godine (nešto više od 20%), što je zabrinjavajuće, prvenstveno zbog njihovog visokog apsolutnog broja. Zaključak. Akutno trovanje alkoholom predstavlja znača­jan deo patologije u ukupnom broju bolesnika koji se leče zbog akutnog trovanja različitim hemijskim materijama. Re­zultati ove analize pokazali su da su određene populacione grupe posebno osetljive na zloupotrebu alkohola do nivoa koji zahteva zdravstveno zbrinjavanje (muška populacija, životne dobi od 19 do 65 godina). Samo mali broj (1% svih bolesnika lečenih nakon akutnog trovanja alkoholom) zah­teva klinički tretman. Dobijeni podaci pružili su osnovu za ciljano preventivno delovanje u određenim populacionim grupama, kao i odgovarajuće planiranje angažovanja pro­fesionalnog medicinskog osoblja, materijalnih, prostornih i drugih kapaciteta. Takođe, oni predstavljaju i osnovu za dodatna detaljna društvena, ekonomska, zdravstvena i druga istraživanja u ovoj oblasti, kao i detaljniju registraciju ove vrste trovanja i uspostavljanje sistema praćenja, kao i baze podataka.

Biografije autora

Zoran Šegrt, Department for Treatment, Military Medical Academy, Belgrade, Serbia;Medical Faculty, Military Medical Academy, Belgrade, Serbia

Assoc. Prof., Head, Department for treatment, Military Medical Academy, Belgrade, Serbia

Slavica Vučinić, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical Faculty, Military Medical Academy, Belgrade, Serbia

Full Prof., Head, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia

Nemanja Rančić, Center for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia; Medical faculty, Military Medical Academy, Belgrade, Serbia

Assist. Res. Prof., Medical Faculty, Military Medical Academy, Belgrade, Serbia

Nataša Vukčević-Perković, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical Faculty, Military Medical Academy, Belgrade, Serbia

Assist. Prof., Clinic for Toxicology, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia;Medical Faculty, Military Medical Academy, Belgrade, Serbia

Gordana Vuković-Ercegović, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical Faculty, Military Medical Academy, Belgrade, Serbia

Assist., Clinic for Toxicology, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia;Medical Faculty, Military Medical Academy, Belgrade, Serbia

Olivera Potrebić, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia

MD, specialist, Clinic for Toxicology, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia

Aleksandra Kovačević, Center for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia; Medical faculty, Military Medical Academy, Belgrade, Serbia

Assist. Prof., Center for Clinical Pharmacology, Military Medical Academy, Belgrade, Serbia;Medical faculty, Military Medical Academy, Belgrade, Serbia

Vesna Mijatović Jovin, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi, Serbia

Assist. Prof., Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi, Serbia

Vesna Jaćević, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia; Medical faculty, Military Medical Academy, Belgrade, Serbia;Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic

Assoc. Res. Prof., Head of Department for experimental toxicology and pharmacology, National Poison Control Centre, Military Medical Academy, Belgrade, Serbia

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2021/05/06
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