Postoperative urinary tract infection after ureteroscopic lithotripsy in patients with asymptomatic bacteriuria

  • Mirko Jovanović Military Medical Academy, Urology Clinic, Belgrade, Serbia
  • Vesna Šuljagić Military Medical Academy, Department of Infection Control, Belgrade, Serbia
  • Vladimir Bančević Military Medical Academy, Urology Clinic, Belgrade, Serbia
Keywords: bacteriuria, lithotripsy, ureteroscopy, postoperative complications, urinary tract infections

Abstract


Background/Aim. Postoperative urinary tract infection (UTI) is one of the most common infective complications of ureteroscopic lithotripsy. Preoperative asymptomatic bacteriuria is not a contraindication for performing ureteroscopic lithotripsy but it can be a significant risk factor for occurrence of severe forms of postoperative urinary infection. Methods. From January 2010 until December 2014 at the Urology Clinic of the Military Medical Academy in Belgrade, 389 patients undergoing ureteroscopic lithotripsy were analyzed, and their postoperative infective complications were monitored. From the group, the incidence of posteoperative urinary infection was analysed in 52 patients with preoperative asymptomatic bacteriuria. Results. Infective complications occured in 18.7% of patients, and postoperative UTI in 10% of patients. Out of 52 patients with preoperative asymptomatic bacteriuria, 36.5% had postoperative urinary tract infection (χ= 46.773; p < 0.001). In these patients, we registered higher frequency of severe forms of postoperative UTI, systemic inflammatory response syndrome (SIRS) and sepsis. Conclusion. Preoperative asymptomatic bacteriuria represents a significant risk factor for developing postoperative UTI following ureteroscopic lithotripsy and is associated with increased risk for occurence of severe forms of SIRS and sepsis. It is desirable that every patient with indicated ureteroscopic lithotripsy has sterile urine culture, and if this is impossible to achieve, a special caution and an adequate antibiotic therapy and prophylaxis are needed before and during the surgical procedure.

References

Türk C, Knoll T, Petrik A, Sarica K, Skolarikos A, Straub M, et al. Guidelines on urolithiasis. Arnhem, Netherlands: European Association of Urology; 2017. Available from: http://uroweb.org/guideline/urolithiasis/.

de la Rosette J, Denstedt J, Geavlete P, Keeley F, Matsuda T, Pearle M, et al. The clinical research office of the endourological so-ciety ureteroscopy global study: indications, complications, and outcomes in 11,885 patients. J Endourol 2014; 28(2): 131‒9.

Fan S, Gong B, Hao Z, Zhang L, Zhou J, Zhang Y, et al. Risk fac-tors of infectious complications following flexible uretero-scope with a holmium laser: a retrospective study. Int J Clin Exp Med 2015; 8(7): 11252‒9.

Martov A, Gravas S, Etemadian M, Unsal A, Barusso G, D'Addessi A, et al. Postoperative infection rates in patients with a negative baseline urine culture undergoing ureteroscop-ic stone removal: a matched case-control analysis on antibiotic prophylaxis from the CROES URS global study. J Endourol 2015; 29(2): 171‒80.

Volkin D, Shah O. Complications of ureteroscopy for stone disease. Minerva Urol Nefrol 2016; 68(6): 570‒85.

Shabeena KS, Bhargava R, Manzoor MAP, Mujeeburahiman M. Characteristics of bacterial colonization after indwelling dou-ble-J ureteral stents for different time duration. Urol Ann 2018; 10(1): 71‒5.

Tolordava ER, Tiganova IG, Alekseeva NV, Stepanova TV, Terekhov AA, Egamberdiev DK, et al. Renal calculus microflora in urolithiasis and search for agents of control of biofilms formed by uropathogenic bacteria. Zh Mikrobiol Epidemiol Immunobiol 2012; (4): 56‒62. (Russian)

Moses RA, Ghali FM, Pais VM Jr, Hyams ES. Unplanned Hospital Return for Infection following Ureteroscopy-Can We Identify Modifiable Risk Factors? J Urol 2016; 195(4 Pt 1): 931‒6.

Berardinelli F, De Francesco P, Marchioni M, Cera N, Proietti S, Hennessey D, et al. Infective complications after retrograde in-trarenal surgery: a new standardized classification system. Int Urol Nephrol 2016; 48(11): 1757‒762.

Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA et al. Definitions for sepsis and organ failure and guide-lines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medi-cine. Chest 1992; 101(6): 1644‒55.

Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31(4): 1250‒6.

Mitsuzuka K, Nakano O, Takahashi N, Satoh M. Identification of factors associated with postoperative febrile urinary tract infection after ureteroscopy for urinary stones. Urolithiasis 2016; 44(3): 257‒62.

Sohn DW, Kim SW, Hong CG, Yoon BI, Ha US, Cho YH. Risk factors of infectious complication after ureteroscopic proce-dures of the upper urinary tract. J Infect Chemother 2013; 19(6): 1102‒8.

Bloom J, Fox C, Fullerton S, Matthews G, Phillips J. Sepsis after elective ureteroscopy. Can J Urol 2017; 24(5): 9017‒23.

Blackmur JP, Maitra NU, Marri RR, Housami F, Malki M, McIl-henny C. Analysis of Factors' Association with Risk of Postop-erative Urosepsis in Patients Undergoing Ureteroscopy for Treatment of Stone Disease. J Endourol 2016; 30(9): 963‒9.

Özsoy M, Acar Ö, Sarica K, Saratlija-Novakovic Z, Fajkovic H, Li-brenjak D, et al. Impact of gender on success and complication rates after ureteroscopy. World J Urol 2015; 33(9): 1297‒302.

Uchida Y, Takazawa R, Kitayama S, Tsujii T. Predictive risk fac-tors for systemic inflammatory response syndrome following ureteroscopic laser lithotripsy. Urolithiasis 2018; 46(4): 375‒81.

Matsumoto M, Shigemura K, Yamamichi F, Tanaka K, Nakano Y, Arakawa S, et al. Prevention of infectious complication and its risk factors after urological procedures of the upper urinary tract. Urol Int 2012; 88(1): 43‒7.

Geavlete P, Georgescu D, Niţă G, Mirciulescu V, Cauni V. Com-plications of 2735 retrograde semirigid ureteroscopy proce-dures: a single-center experience. J Endourol 2006; 20(3): 179‒85.

Eswara JR, Shariftabrizi A, Sacco D. Positive stone culture is as-sociated with a higher rate of sepsis after endourological pro-cedures. Urolithiasis 2013; 41(5): 411‒4.

Published
2021/03/04
Section
Original Paper