Performance on the Rey-Osterrieth complex figure test and the correlation with the magnetic resonance imaging brain lesion volume in multi-infarct versus small vessel disease dementia

Marija D Semnić; Robert Semnić; Željka Nikolašević; Vojislava V Bugarski Ignjatović; Tijana Ž Vujanić Stankov; Smiljana Kostić; Gordana Ocić; Duško Kozić

doi:10.2298/VSP191220039S

Marija D Semnić University of Novi Sad, Faculty of medicine, Department for Neurology; Clinical centre of Vojvodina, Clinic for Neurology
Robert Semnić Department of Surgical Sciences, Radiology, Uppsala University, Uppsala,
Željka Nikolašević University of Novi Sad, Faculty of medicine, Department for psychology
Vojislava V Bugarski Ignjatović University of Novi Sad, Faculty of medicine, Department for psychology ;Clinical centre of Vojvodina, Clinic for Neurology
Tijana Ž Vujanić Stankov University of Novi Sad, Faculty of medicine, Department for Neurology; Clinical centre of Vojvodina, Clinic for Neurology
Smiljana Kostić Military Medical Academy, Belgrade, Clinic for Neurology; University of Defence, Faculty of Medicine of Military Medical Academy, Department for Neuropsychiatric Science
Gordana Ocić Neurocentar Ocic, Belgrade
Duško Kozić University of Novi Sad, Faculty of medicine, Department for Radiology;Vojvodina Institute of Oncology, Sremska Kamenica, Center for Diagnostic Imaging

DOI: https://doi.org/10.2298/VSP191220039S

Keywords: dementia, vascular;, cerebrovascular disorders;, neurologic manifestations;, neurologic examination;, magnetic resonance imaging;, memory disorders

Abstract

Background/Aim. Regarding several cognitive domains, including visuospatial and visuoconstructional abilities, little is known about the differences between vascular dementia (VaD) subtypes, even in the most common subtypes, such as multi-infarct dementia (MID) and subcortical ischemic small vessel disease dementia (SSVD). This paper aimed to identify the differences between the performances on the Rey-Osterrieth Complex Figure (ROCF) test in MID and SSVD and correlate the ROCF scores in both groups with magnetic resonance imaging (MRI) ischemic lesion load. Methods. Sixty VaD patients with matching severity of dementia, age, and education were included in this study: 32 with SSVD and 28 with MID according to the NINDS-AIREN (National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherché et l'Enseignement en Neurosciences) neuroradiological criteria. A quantitative scoring system was performed. ROCF was given to all subjects in three test conditions: copy, immediate recall after 3 minutes, and delayed recall after 45 min. Magnetic resonance imaging (MRI) of the ischemic brain volumes of anterior and posterior lesions, left and right hemispheric lesions, left and right-sided basal ganglia lesions, and total lesion load (TLL) were calculated in both groups. Results. The MID group was more impaired than SSVD on ROCF copy (p = 0.008), immediate recall (p= 0.005) and delayed recall (p = 0.001). There were significant correlations between ROCF copy score and the TLL (p < 0.05) and posterior brain lesion volume (p< 0.05) in the MID group. Conclusion. The importance of visuospatial, visuoconstructional deficit and impairment of visual memory is disregarded in VaD subtypes. These impairments are more severe in MID than SSVD and the deficit of ROCF copying in MID patients correlates with posterior and total MRI lesion volume.

Author Biographies

Marija D Semnić, University of Novi Sad, Faculty of medicine, Department for Neurology; Clinical centre of Vojvodina, Clinic for Neurology

Assistant Professor, Department for Neurology, Faculty of medicine, University of Novi Sad

Željka Nikolašević, University of Novi Sad, Faculty of medicine, Department for psychology

Teaching Assistant (PhD), Department for Psychology, Faculty of medicine, University of Novi Sad;

Vojislava V Bugarski Ignjatović, University of Novi Sad, Faculty of medicine, Department for psychology ;Clinical centre of Vojvodina, Clinic for Neurology

Assistant Professor, Department for Psychology, Faculty of medicine, University of Novi Sad

Tijana Ž Vujanić Stankov, University of Novi Sad, Faculty of medicine, Department for Neurology; Clinical centre of Vojvodina, Clinic for Neurology

Research Associate, Department for Neurology, Faculty of medicine, University of Novi Sad

Smiljana Kostić, Military Medical Academy, Belgrade, Clinic for Neurology; University of Defence, Faculty of Medicine of Military Medical Academy, Department for Neuropsychiatric Science

Teaching Assistant (PhD), Department for Neuropsychiatric Science, Faculty of Medicine of Military Medical Academy, University of Defence

Gordana Ocić, Neurocentar Ocic, Belgrade

Retired Professor of neurology

Duško Kozić, University of Novi Sad, Faculty of medicine, Department for Radiology;Vojvodina Institute of Oncology, Sremska Kamenica, Center for Diagnostic Imaging

Full Professor, Department for Radiology, Faculty of medicine, University of Novi Sad;

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