Degree of cognitive impairment in patients with carotid stenosis in relation to cerebral ischemic lesions

Elena Joveva; Gordana Djordjević; Vuk Milošević; Anita Arsovska; Miroslava Živković

doi:10.2298/VSP200502082J

Elena Joveva University Goce Delčev, Faculty of Medical Sciences, Clinical Hospital of Štip, Štip, Republic of North Macedonia
Gordana Djordjević Clinical Center Niš, Clinic of Neurology, Niš, Serbia
Vuk Milošević Clinical Center Niš, Clinic of Neurology, Niš, Serbia
Anita Arsovska University Clinic of Neurology, Skopje, Republic of North Macedonia
Miroslava Živković Clinical Center Niš, Clinic of Neurology, Niš, Serbia

DOI: https://doi.org/10.2298/VSP200502082J

Keywords: cognition disorders;, carotid stenosis;, diagnosis;, magnetic resonance imaging;, severity of illness index;, risk factors;, x-ray computed tomography

Abstract

Background/Aim. Carotid stenosis is a risk factor for cognitive impairment. The aim of the study was to evaluate the degree of cognitive impairment in patients with asymptomatic and symptomatic carotid stenosis and correlate it with the presence, location, and extent of cerebral ischemic lesions. Methods. A prospective analysis of 180 patients aged 50–70 years, divided into three groups (asymptomatic carotid stenosis, symptomatic carotid stenosis, and controls) was made. We assessed demographic characteristics, vascular risk factors, ultrasound examination of the carotid arteries, computerized tomography (CT), magnetic resonance imaging (MRI) of the brain, and neuropsychological testing. Results. The brain CT findings on admission showed ischemic lesions in the left hemisphere in 13.3% of patients in the asymptomatic group and in 41% of those in the symptomatic group. In the right hemisphere, lesions were registered in 10% of the asymptomatic patients and in 46.7% of the symptomatic patients. The difference between groups was statistically significant. The lesion volumes measured on CT and MRI scans were significantly different (p < 0.001) between groups with asymptomatic and symptomatic carotid stenosis. The degree of cognitive impairment, measured by the Addenbrooke's Cognitive Examination Revised (ACE-R), was significantly different between the groups (p < 0.05), with the most severe deficit in the symptomatic group. Conclusion. Our study has shown that cognitive impairment was more severe in patients with symptomatic carotid stenosis, compared to the patients with asymptomatic carotid stenosis.

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