Klinička ispitivClinical trials of resveratrol efficacy and safetyanja delotvornosti resveratrola

Sun AY, Ribes AM, Leandro MC, Belchior AP, Spranger MI. Stilbenes: Quantitative extraction from grape skins, contribu-tion of grape solids to wine and variation during wine matura-tion. Anal Chim Acta 2006; 563: 382‒90.

Püssa T, Floren J, Kuldkepp P, Raal A. Survey of grapevine Vitis vinifera stem polyphenols by liquid chromatography-diode ar-ray detection-tandem mass spectrometry. J Agric Food Chem 2006; 54(20): 7488‒94.

Atanacković M, Petrović A, Jović S, Gojković-Bukarica Lj, Bursać M, Cvejić J. Influence of winemaking techniques on the resveratrol content, total phenolic content and antioxidant potential of red wines. Food Chem 2012; 131(2): 513–8.

Cvejić J, Puškaš V, Miljić U, Torović Lj, Rakić D. Probus, Rumenika and Frankovka red wines from Fruška gora (Serbia): Varietal differentiation and changes of phenolic compounds during maceration. J Food Sci Technol 2016; 242: 1319‒29.

Cvejic JM, Djekic SV, Petrovic AV, Atanackovic MT, Jovic SM, Brceski ID, et al. Determination of trans- and cis-resveratrol in Serbian commercial wines. J Chromatogr Sci 2010; 48(3): 229‒34.

Vastano BC, Chen Y, Zhu N, Ho CT, Zhou Z, Rosen RT. Isola-tion and identification of stilbenes in two varieties of Polygo-num cuspidatum. J Agric Food Chem 2000; 48(2): 253‒6.

Abolaji AO, Adedera AO, Adie MA, Vicente-Crespo M, Farombi EO. Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster. Biochem Biophys Res Commun 2018; 503: 1042‒8.

Hsu HT, Tseng YT, Wong WJ, Liu CM, Lo YC. Resveratrol prevents nanoparticles-induced inflammation and oxidative stress via down regulation of PKC-α and NADPH oxidase in lung epithelial A549 cells. BMC Complement Altern Med 2018; 18(1): 211.

Qin N, Tan X, Jiao Y, Liu L, Zhao W, Yang S, et al. RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol. Sci Rep 2014; 4: 5467.

Xu K, Liu XF, Ke ZQ, Yao Q, Guo S, Liu C. Resvera-trol Modulates Apoptosis and Autophagy Induced by High Glucose and Palmitate in Cardiac Cells. Cell Physiol Biochem 2018; 46(5): 2031‒40.

Novelle MG, Wahl D, Diéguez C, Bernier M, de Cabo R. Resveratrol supplementation: Where are we now and where should we go? Ageing Res Rev 2015; 21: 1‒15.

Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, et al. Cancer chemoprevention: Evidence of a nonlinear dose re-sponse for the protective effects of resveratrol in humans and mice. Sci Transl Med 2015; 7(298): 298ra117.

Protić D, Radunović N, Spremović-Rađenović S, Živanović V, Heinle H, Petrović A, et al. The Role of Potassium Channels in the Va-sodilatation Induced by Resveratrol and Naringenin in Iso-lated Human Umbilical Vein. Drug Dev Res 2015; 76(1): 17‒23.

Bukarica LG, Protić D, Kanjuh V, Heinle H, Novaković R, Sćepanović R. Cardiovascular effects of resveratrol. Vojno-sanit Pregl 2013; 70(12): 1145‒50.

Bo S, Ciccone G, Castiglione A, Gambino R, De Michieli F, Villos P, et al. Anti-inflammatory and antioxidant effects of resvera-trol in healthy smokers a randomized, double-blind placebo-controlled, cross-over trial. Curr Med Chem 2013; 20(10): 1323‒31.

Tome-Carneiro J, Gonzalvez M, Larrosa M, Yanez-Gascon MJ, Garcia-Almagro FJ, Ruiz-Ros JA, et al. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol 2012; 110(3): 356‒63.

Militaru C, Donoiu I, Craciun A, Scorei ID, Bulearca AM, Scorei RI. Oral resveratrol and calcium fructoborate supplementa-tion in subjects with stable angina pectoris: effects on lipid profiles, inflammation markers, and quality of life. Nutrition 2013; 29(1): 178-83.

Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, Fulop A, et al. Cardioprotection by resveratrol: A human clinical trial in pa-tients with stable coronary artery disease. Clin Hemorheol Mi-crocirc 2012; 50(3): 179‒87.

Tome-Carneiro J, Gonzalvez M, Larrosa M, Garcia-Almagro FJ, Aviles-Plaza F, Parra S. Consumption of a grape extract sup-plement containing resveratrol decreases oxidizes LDL and ApoB in patients undergoing primary prevention of cardiovas-cular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol Nutr Food Res 2012; 56(5): 810‒21.

Simental-Mendia LE, Guerrero-Romero F. Effect of resveratrol supplementation on lipid profile in subjects with dyslipidemia: A randomized double-blind, placebo-controlled trial. Nutri-tion 2019; 58: 7-10.

Sahebkar A. Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev 2013; 71(12): 822‒35.

Haghighatdoost F, Hariri M. Effect of resveratrol on lipid pro-file: An updated systematic review and meta-analysis on ran-domized clinical trials. Pharmacol Res 2018; 129: 141‒50.

Fogacci F, Tocci G, Presta V, Fratter A, Borghi C, Cicero AFG. Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Crit Rev Food Sci Nutr 2019; 59(10): 1605‒18.

Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevat-ed blood pressure. Nutr Metab Cardiovasc Dis 2011; 21: 851‒6.

Wong RH, Berry NM, Coates AM, Buckley JD, Bryan J, Kunz I, et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J Hypertens 2013; 31(9): 1819‒27.

Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, et al. Effects of resveratrol on cerebral blood flow varia-bles and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr 2010; 91(6): 1590‒7.

Movahed A, Nabipour I, Lieben Louis X, Thandapilly SJ, Yu L, Kalantarhormozi M, et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med 2013; 2013: 851267.

Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res 2012; 32(7): 537–41.

Brasnyo P, Molnar GA, Mohas M, Marko L, Laczy B, Cseh J, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic pa-tients. Br J Nutr 2011; 106(3): 383–9.

Poulsen MM, Vestergaard PF, Clasen BF, Radko Y, Christensen LP, Stødkilde-Jørgensen H, et al. High-dose resveratrol supple-mentation in obese men: an investigator-initiated, random-ized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 2013; 62(4): 1186‒95.

Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, et al. Resveratrol supplementation does not improve met-abolic function in nonobese women with normal glucose tol-erance. Cell Metab 2012; 16(5): 658‒64.

Walker JM, Eckardt P, Aleman JO, da Rosa JC, Liang Y, Iizumi T, et al. The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syn-drome: A pilot randomized, placebo-controlled clinical trial. J Clin Transl Res 2018; 4(2): 122‒35.

Zhu W, Qin W, Zhang K, Rotttinghaus GE, Chen YC, Kliethermes B, et al. Trans-resveratrol alters mammary promoter hyper-methylation in women at increased risk for breast cancer. Nutr Cancer 2012; 64(3): 393‒400.

Howells LM, Berry DP, Elliot PJ, Jacobson EW, Hoffmann E, Hedarty B, et al. Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res (Phila) 2011; 4(9): 1419‒25.

Popat R, Plesner T, Davies F, Cook G, Cook M, Elliott P, et al. A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br J Haematol 2013; 160(5): 714‒7.

Ponzo V, Soldati L, Bo S. Resveratrol: a supplementation for men or for mice? J Transl Med 2014; 12: 158.

Smoliga JM, Baur JA, Hausenblas HA. Resveratrol and health- A comprehensive review of human clinical trials. Mol Nutr Food Res 2011; 55(8): 1129‒41.

Patel KP, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K. Clinical trials of resveratrol. Ann N Y Acad Sci 2011; 1215: 161‒9.