Sudden sustained monomorphic ventricular tachycardia in a previously healthy adult with many causes for it, but which is the correct one?

  • Zoran Jović Military Medical Academy, *Clinic of Cardiology, ‡Clinic of Emergency Internal Medicine, Belgrade, Serbia; University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia
  • Miljan Opančina Military Medical Academy, Clinic of Cardiology, Belgrade, Serbia
  • Zorica Mladenović Military Medical Academy, Clinic of Cardiology, Belgrade, Serbia; University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia
  • Predrag Djurić Military Medical Academy, Clinic of Cardiology, Belgrade, Serbia
  • Ivica Djurić Military Medical Academy, Clinic of Cardiology, Belgrade, Serbia
  • Jelena Marić Kocijančić Military Medical Academy, Clinic of Cardiology, Belgrade, Serbia
  • Nemanja Djenić Military Medical Academy, Clinic of Emergency Internal Medicine, Belgrade, Serbia University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia
  • Valentina Opančina University of Kragujevac, Faculty of Medical Sciences, Department of Radiology, Kragujevac, Serbia
  • Slobodan Obradović Military Medical Academy, Clinic of Cardiology Belgrade, Serbia; University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia
Keywords: cardiomyopathies;, coronary disease;, defibrillators, implantable;, diagnosis;, magnetic resonance imaging;, myocardial bridging;, tachycardia, ventricular;, ultrasonography

Abstract


Introduction. Sustained monomorphic ventricular tachycardia (VT) – SMVT is a rare, underdiagnosed pathology with a very poor prognosis. Along with ventricular fibrillation, SMVT is responsible for nearly all of the arrhythmic sudden cardiac deaths (SCD). The most common cause of VT is ischemic heart disease, but there are many other reasons, among which are arrhythmogenic right ventricular cardiomyopathy (ARVD) and myocardial bridging phenomenon. Treatment options include a hybrid approach consisting of antiarrhythmic drugs, catheter ablation, and implantable cardioverter defibrillators (ICD). Case report. We present a case of a 46-year-old man, a military officer, who experienced chest pain, palpitations, and nausea during regular physical activity at home. Due to the symptoms described, he was examined immediately and diagnosed with SMVT. Shortly after the diagnosis, he lost consciousness and was successfully resuscitated. A complete non-invasive and invasive cardiology examination was performed. It revealed that the patient had stable coronary disease and a muscle bridge on the left anterior descending artery. An ARVD was suspected after transthoracic echocardiography and heart magnetic resonance imaging. Genetic testing for ARVD was negative, but according to the Heart Rhythm Society expert consensus criteria, we had enough for a definitive diagnosis. The patient was hospitalized for ten days and treated with drugs without recurring VT or other disorders. We implanted an implantable loop recorder before the discharge and monitored the heart rhythm for one year. During a three-year follow-up, all of his electrocardiographic findings presented sinus rhythm without heart rhythm disorders. Conclusion. Sudden SMVT is the most common cause of SCD. It is of inestimable importance to carry out a detailed examination and determine the immediate cause of the arrhythmia and the right therapy, which, for these patients, is a life-saving form of treatment. Therapy includes medications, electrophysiology or ICD, or a combination of these treatment approaches.

Author Biography

Zoran Jović, Military Medical Academy, *Clinic of Cardiology, ‡Clinic of Emergency Internal Medicine, Belgrade, Serbia; University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, Serbia

Klinika za kardiologiju

 

References

Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J 2022; 43(40): 3997–4126.

John RM, Tedrow UB, Koplan BA, Albert CM, Epstein LM, Sweeney MO, et al. Ventricular arrhythmias and sudden car-diac death. Lancet 2012; 380(9852): 1520–9.

American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (ACC/AHA/HRS Writing Committee to Develop Data Standards on Electrophysiology); Buxton AE, Calkins H, Callans DJ, DiMarco JP, Fisher JD, et al. ACC/AHA/HRS 2006 key data elements and definitions for electrophysiological studies and procedures: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (ACC/AHA/HRS Writing Committee to Develop Data Standards on Electro-physiology). Circulation 2006; 114(23): 2534–70.

Talwar KK, Naik N. Etiology and management of sustained ventricular tachycardia. Am J Cardiovasc Drugs 2001; 1(3): 179–92.

Erbel R, Ge J, Möhlenkamp S. Myocardial bridging: a con-genital variant as an anatomic risk factor for myocardial in-farction? Circulation 2009; 120(5): 357–9.

Marchionni N, Chechi T, Falai M, Margheri M, Fumagalli S. Myocardial stunning associated with a myocardial bridge. Int J Cardiol 2002; 82(1): 65–7.

GBD 2013 Mortality and Causes of Death Collaborators. Glob-al, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Dis-ease Study 2013. Lancet 2015; 385(9963): 117–71.

Sen-Chowdhry S, Lowe MD, Sporton SC, McKenna WJ. Ar-rhythmogenic right ventricular cardiomyopathy: clinical presentation, diagnosis, and management. Am J Med 2004; 117(9): 685–95.

Gemayel C, Pelliccia A, Thompson PD. Arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol 2001; 38(7): 1773–81.

Tarantini G, Migliore F, Cademartiri F, Fraccaro C, Iliceto S. Left Anterior Descending Artery Myocardial Bridging: A Clinical Approach. J Am Coll Cardiol 2016; 68(25): 2887–99.

Ciçek D, Kalay N, Müderrisoğlu H. Incidence, clinical charac-teristics, and 4-year follow-up of patients with isolated myocardial bridge: a retrospective, single-center, epidemio-logic, coronary arteriographic follow-up study in southern Turkey. Cardiovasc Revasc Med 2011; 12(1): 25–8.

Lee MS, Chen CH. Myocardial Bridging: An Up-to-Date Re-view. J Invasive Cardiol 2015; 27(11): 521–8.

Gula LJ, Klein GJ, Hellkamp AS, Massel D, Krahn AD, Skanes AC, et al. Ejection fraction assessment and survival: an analy-sis of the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Am Heart J 2008; 156(6): 1196–200.

Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm 2018; 15(10): e190–252. Erratum in: Heart Rhythm 2018; 15(11): e278–81.

Corrado D, Link MS, Calkins H. Arrhythmogenic Right Ven-tricular Cardiomyopathy. N Engl J Med 2017; 376(1): 61–72.

Markman TM, Nazarian S. Treatment of ventricular arrhyth-mias: What's New? Trends Cardiovasc Med 2019; 29(5): 249–61.

Tichnell C, James CA, Murray B, Tandri H, Sears SF, Calkins H. Cardiology patient page. Patient's guide to arrhythmogenic right ventricular dysplasia/cardiomyopathy: past to present. Circulation 2014; 130(10): e89–92.

De Brouwer R, Bosman LP, Gripenstedt S, Wilde AAM, van den Berg MP, Peter van Tintelen J, et al. Value of genetic testing in the diagnosis and risk stratification of arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm 2022; 19(10): 1659–65.

Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, et al. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of ar-rhythmogenic cardiomyopathy. Heart Rhythm 2019; 16(11): e301–72.

Published
2024/02/29
Section
Case report