Quantitative study of lung structure in COPD patients based on  low-dose Karl iterative reconstruction

Yizhai  Ye; Juehui  Li; Weigen  Wang; Jianhua  He; Qi Yang

doi:10.2298/VSP240607008Y

Yizhai Ye Ninghai First Hospital, Department of Radiology, Ningbo, Zhejiang Province, China
Juehui Li Baoan District Hospital of Traditional Chinese Medicine, Department of Pulmonary Diseases/Respiratory and Critical Care Medicine, Shenzhen, China
Weigen Wang Ninghai First Hospital, Department of Radiology, Ningbo, Zhejiang Province, China
Jianhua He Ninghai First Hospital, Department of Radiology, Ningbo, Zhejiang Province, China
Qi Yang The First Hospital of Jiaxing (Affiliated Hospital of Jiaxing University), Department of Respiratory, Jiaxing, Zhejiang Province, China

DOI: https://doi.org/10.2298/VSP240607008Y

Keywords: airway remodeling;, algorithms;, tomography, x-ray computed;, diagnostic techniques and procedures;, pulmonary disease, chronic obstructive.

Abstract

Background/Aim. Low-dose Karl iterative reconstruction (KIR) is a commonly used technique in medical imaging. An iterative algorithm reduces the dose of X-ray radiation while ensuring image quality, making it a safer and more convenient imaging method. The aim of the study was to analyze the assessment value of low-dose KIR for the lung structure of patients with chronic obstructive pulmonary disease (COPD). Methods. The study included a total of 135 COPD patients undergoing bronchoscopic biopsy from August 2022 to July 2023. Low-dose KIR was conducted. Two groups were formed according to the lung structure examined by bronchoscopic biopsy: an airway remodeling group and a non-airway remodeling group. The examination indicators of low-dose KIR were compared. Receiver operating characteristic curves were plotted to analyze the clinical value of low-dose KIR for assessing the lung structure. Results. According to the examination results of chest X-ray, airway remodeling was done in 85 out of 135 (62.96%) COPD patients. The sensitivities, specificities, and areas under the curves of computed tomography value, noise value, signal-to-noise ratio, and contrast-to-noise ratio were 0.976 vs. 0.965 vs. 0.953 vs. 0.980, 0.960 vs. 0.940 vs. 0.927 vs. 0.753, and 0.623 vs. 0.643 vs. 0.670 vs. 0.640, respectively. Conclusion. Low-dose KIR proved to be a very accurate and fast method for the quantitative study of lung structure in COPD patients.

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