Palliative embolization of renal tumors

  • Suad a Jaganjac Schönklinik Hamburg Eilbek Abteilung für diagnostische und interventionelle Radiologie
  • Lennart Schefe Department of Radiology, Schön Klinik Hamburg Eilbek, Hamburg, Germany

Abstract


Background/Aim. Palliative embolization of renal tumors is the method of choice in the treatment of advanced inoperable renal cell carcinoma in patients with hematuria and pain. Patients with small tumors in the remaining solitary  kidney who refuse surgery  are suitable for this type of therapy as well as patients with centrally located inoperable tumors. The prerequisite for successful capillary embolization is the closure of the main arterial trunk with metal spirals. Methods. In the period from 2000 to 2010 we conducted 42 palliative embolizations. The average age of the patients was 75 years, including 26 men and 16 women. In 8 of the patients the intervention was repeated and in one with severe AV shunts embolization was performed 4 times. Embolization was performed with alcohol, Ivalon 150–250 μm and with metal coils. Results. No serious complications were observed during and after the intervention. Fourteen patient were still alive then and among the deceased patients the average survival time was 13.5 ± 10.8 months with the range of 1 to 56 months. The minimal survival time was 1 month with a maximum survival time of 56 months. Conclusion. Our results are consistent with data in the literature. Survival in patients without metastases was longer than in those with metastases, as confirmed by the 14 of the patients from the study. An additional therapeutic safety in the treatment of small cancers is provided with a combination therapy of embolization and radiofrequency thermoablation.

 

Key words:

kidney neoplasms; carcinoma, renal cell; hematuria; palliative care; embolization, therapeutic; radiography, interventional.

References

Lalli AF, Peterson N, Bookstein JJ. Roentgen-guided infarctions of kidneys and lungs. A potential therapeutic technic. Radiology. 1969; 93(2): 434–5.

Almgård LE, Fernström I, Haverling M, Ljungqvist A. Treatment of renal adenocarcinoma by embolic occlusion of the renal cir-culation. Br J Urol 1973; 45(5): 474−9.

Marx FJ, Chaussy C, Moser E. Limitations and hazards of palliative renal tumor embolization. Urologe A 1982; 21(4): 206−10.

Onishi T, Oishi Y, Yanada S, Abe K, Hasegawa T, Maeda S. Prognostic implications of histological features in patients with chromophobe cell renal carcinoma. BJU Int 2002; 90(6): 529−32.

Hansmann HJ, Hallscheidt P, Aretz K, Kauffmann GW, Richter GM. Renal tumor embolization. Radiologe 1999; 39(9): 783−9.

Kauffmann GW, Richter GM, Roeren TK. Renal tumor emboliza-tion. Radiologe 1992; 32(3): 127−31.

Demirci D, Tatlişen A, Ekmekçioğlu O, Ozcan N, Kaya R. Does radical nephrectomy with immunochemotherapy have any su-periority over embolization alone in metastatic renal cell carci-noma? A preliminary report. Urol Int 2004; 73(1): 54−8.

Hallscheidt P, Besharati S, Noeldge G, Haferkamp A, Lopez R, Kauffmann G. Präoperative und palliative Embolisation des Nierenzellkarzinoms: Nachsorge von 49 Patienten. RöFo 2006; 178(4): 391−9.

Maxwell NJ, Saleem AN, Rogers E, Kiely D, Sweeney P, Brady AP. Renal artery embolisation in the palliative treatment of renal carcinoma. Br J Radiol 2007; 80(950): 96−102.

Vaicekavicius E, Pranculis A. Transcatheter renal arterial embolization in malignant renal neoplasms: clinical results and indications for use of the method in multi-profile hospitals. Medicina (Kaunas) 2002; 38(9): 888−91.

Munro NP, Woodhams S, Nawrocki JD, Fletcher MS, Thomas PJ. The role of transarterial embolization in the treatment of renal cell carcinoma. BJU Int 2003; 92(3): 240−4.

Kauffmann GW, Rohrbach R, Richter G, Rassweiler J, Sommerkamp H. Kidney tumor embolization. Progress, experiences and complications. Urologe A 1984; 23(2): 109−16.

Löhr E, Ross S. Embolisations-Therapie von Nierentumoren-Erfahrungen an einem Krankengut von 60 Patienten. Radi-ologe 1985; 25: 354−8.

Cox GG, Lee KR, Price HI, Gunter K, Noble MJ, Mebust WK. Colonic infarction following ethanol embolization of renal-cell carcinoma. Radiology 1982; 145(2): 343−5.

Teertstra HJ, Winter WA, Frensdorf EL. Ethanol embolization of a renal tumor, complicated by colonic infarction. Diagn Imaging Clin Med 1984; 53: 250−4.

Sutherland PD, Howard PR, Marshall VR. Colonic infarction following ethanol embolisation of the kidney. Br J Urol 1986; 58(2−4): 337.

Laarmann S, Straube W, Timmermann J. Toxic alcohol-induced gonadal damage caused by alcohol embolization of kidney tu-mors. Urologe A 1987; 26(2): 94−5.

Siniluoto TM, Hellström PA, Päivänsalo MJ, Leinonen AS. Testicular infarction following ethanol embolization of a renal neoplasm. Cardiovasc Intervent Radiol 1988; 11(3): 162−4.

Gang DL, Dole KB, Adelman LS. Spinal cord infarction follow-ing therapeutic renal artery embolization. JAMA 1977; 237(26): 2841–2.

Lang EK, Sullivan J, DeKernion JB. Work in progress: transcatheter embolization of renal cell carcinoma with radioactive infarct particles. Radiology 1983; 147(2): 413−8.

Schwartz MJ, Smith EB, Trost DW, Vaughan EDJr.. Renal artery embolization: clinical indications and experience from over 100 cases. Br J Urol 2007; 99(4): 881−6.

Cofan F, Real M, Vilardell J, Montanya X, Blasco J, Martin P, et al. Percutaneous renal artery embolisation of non-functioning renal allografts with clinical intolerance. Transpl Int 2002; 15(4): 149−55.

Basche S. Gas formation following renal tumor embolization. RöFo 1987; 147(4): 459−60.

Weckermann D, Schlotmann R, Tietze W, Häckel T. Gas formation after renal artery embolisation: genesis and clinical relevance. Urol Int 1992; 49(4): 211−4.

Published
2017/01/20
Section
Original Paper